Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2

Journal of Neurochemistry

Volumn 75, Issue 5, 2000, Pages 1907-1916

  Asaba, Hiroshi ^a,b   Hosoya, Ken Ichi ^a,b   Takanaga, Hitomi ^a,b   Ohtsuki, Sumio ^a,b   Tamura, Etsuko ^a,b   Takizawa, Takuya ^a,b   Terasaki, Tetsuya ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Blood brain barrier; Conditionally immortalized mouse brain capillary endothelial cell line; Dehydroepiandrosterone sulfate; Efflux transport; Organic anion transporting polypeptide 2

Indexed keywords

DIGOXIN; METHOTREXATE; ORGANIC ANION TRANSPORTER 2; POLYPEPTIDE; PRASTERONE SULFATE; PROBENECID; STEROID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CAPILLARY ENDOTHELIUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; JUGULAR VEIN; MALE; MICHAELIS MENTEN KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TRANSPORT; SEQUENCE ANALYSIS;

ANIMALS; ANION TRANSPORT PROTEINS; ANIONS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CARRIER PROTEINS; CELLS, CULTURED; DEHYDROEPIANDROSTERONE SULFATE; DIGOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; INULIN; MALE; MICE; MICE, TRANSGENIC; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ANIMALIA;

EID: 0033794507     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751907.x     Document Type: Article

References (33)

1. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
2. The effect of dehydroepiandrosterone sulfate administration to patients with multi-infarct dementia
3. The blood-brain barrier, a dynamic regulatory interface
4. Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells
5. Dehydroepiandrosterone and its sulfate enhance memory retention in mice
6. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
7. The glucose transporter family: Structure, function and tissue-specific expression
8. Cortisol, dehydroepiandrosterone (DHEA), and DHEA sulfate in the cerebrospinal fluid of man: Relation to blood levels and the effects of age
9. Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X
10. Blood-brain barrier produces significant efflux of L-aspartic acid, but not D-aspartic acid: In vivo evidence using the brain efflux index method
11. +-independent organic anion transporter
12. Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier
13. Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: In vivo evidence by use of the brain efflux index method
14. Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2)
15. Estradiol 17β-D-glucuronide is a high-affinity substrate for oatp organic anion transporter
16. Dehydroepiandrosterone sulphate in rat brain: Incorporation from blood and metabolism in vivo
17. Functional characterization of the basolateral rat liver organic anion transporting polypeptide
18. Dehydroepiandrosterone sulfate (DHEAS): Identification of a carrier protein in human liver and brain
19. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line
20. 4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter
21. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
22. In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier
23. Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier
24. Localization and function of the organic anion-transporting polypeptide (Oatp2) in rat liver
25. Transport of dehydroepiandrosterone and dehydroepiandrosterone sulphate into rat hepatocytes
26. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney
27. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
28. An in situ brain perfusion technique to study cerebrovascular transport in the rat
29. In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system
30. P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells
31. Actions of dehydroepiandrosterone and its sulfate in the central nervous system: Effects on cognition and emotion in animals and humans
32. A pharmacokinetic analysis program (MULTI) for microcomputer