CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]-N,N′- diphenylureas

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 9, 2004, Pages 2295-2306

  Imamura, Shinichi ^a   Kurasawa, Osamu ^a   Nara, Yoshi ^a   Ichikawa, Takashi ^a   Nishikawa, Youichi ^a   Iida, Takehiro ^a   Hashiguchi, Shohei ^a   Kanzaki, Naoyuki ^a   Iizawa, Yuji ^a   Baba, Masanori ^b   Sugihara, Yoshihiro ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

CCR5 antagonist; Chemokine; HIV 1; N,N Diphenylurea

Indexed keywords

4 [[[[3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL](PHENYL)AMINO]CARBONYL]AMINO]BENZAMIDE; 4 [[[[3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL](PHENYL)AMINO]CARBONYL]AMINO]BENZOIC ACID; 4 BENZYLPIPERIDINE; ANTIVIRUS AGENT; CARBANILAMIDE DERIVATIVE; CHEMOKINE RECEPTOR CCR5; ETHYL 4 [[[3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL(PHENYL)AMINO]CARBONYL]AMINO]BENZOATE; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N (3 CHLOROPHENYL) N' (4 CHLOROPHENYL)UREA; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N' (4 CHLOROPHENYL) N (3,4 DICHLOROPHENYL)UREA; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N' (4 CHLOROPHENYL) N (4 METHYLPHENYL)UREA; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N' (4 CHLOROPHENYL) N PHENYLUREA; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N' METHYL N,N' DIPHENYLUREA; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N,N' DIPHENYLUREA; N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N PHENYL N' [4 (TRIFLUOROMETHYL)PHENYL]UREA; N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N' (4 FLUOROPHENYL) N PHENYLUREA; N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N' (4 ISOPROPYLPHENYL) N PHENYLUREA; N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N' (4 METHOXYPHENYL) N PHENYLUREA; N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N' (4 METHYLPHENYL) N PHENYLUREA; N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N' [4 (METHYLSULFANYL)PHENYL] N PHENYLUREA; N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N' [4 (METHYLSULFONYL)PHENYL] N PHENYLUREA; N' (4 BROMOPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N PHENYLUREA; N' (4 CHLOROPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N PHENYLUREA; N' (4 CHLOROPHENYL) N [3 [4 [4 (METHYLSULFONYL)BENZYL]PIPERIDIN 1 YL]PROPYL] N PHENYLUREA; N' (4 CHLOROPHENYL) N [3 [4 [4 (MORPHOLIN 4 YLSULFONYL)BENZYL]PIPERIDIN 1 YL]PROPYL] N PHENYLUREA; N' (4 CYANOPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] N PHENYLUREA; PHENYL GROUP; PIPERIDINE DERIVATIVE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; INHIBITION KINETICS; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS ENVELOPE;

ANIMALS; ANTI-HIV AGENTS; CARBANILIDES; CHO CELLS; CRICETINAE; HIV-1; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE FUSION; RECEPTORS, CCR5;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 11144356726     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.02.004     Document Type: Article

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