1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 20, 2002, Pages 3001-3004

  Lynch, Christopher L ^a   Hale, Jeffrey J ^a   Budhu, Richard J ^a   Gentry, Amy L ^a   Mills, Sander G ^a   Chapman, Kevin T ^a   MacCoss, Malcolm ^a   Malkowitz, Lorraine ^a   Springer, Martin S ^a   Gould, Sandra L ^a   DeMartino, Julie A ^a   Siciliano, Salvatore J ^a   Cascieri, Margaret A ^a   Carella, Anthony ^a   Carver, Gwen ^a   Holmes, Karen ^a   Schleif, William A ^a   Danzeisen, Renee ^a   Hazuda, Daria ^a   Kessler, Joseph ^a   Lineberger, Janet ^a   Miller, Michael ^a   Emini, Emilio A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ALPHA (PYRROLIDIN 1 YL)ACETIC ACID; AMPHOLYTE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR CCR5; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; HUMAN IMMUNODEFICIENCY VIRUS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-HIV AGENTS; CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHYSICAL; CHO CELLS; CRICETINAE; HELA CELLS; HIV-1; HUMANS; INDICATORS AND REAGENTS; MACROPHAGE INFLAMMATORY PROTEIN-1; PYRROLIDINES; RATS; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18644372005     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00606-6     Document Type: Article

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