CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 1, 2004, Pages 63-73

  Imamura, Shinichi ^a   Ishihara, Yuji ^a   Hattori, Taeko ^a   Kurasawa, Osamu ^a   Matsushita, Yoshihiro ^a   Sugihara, Yoshihiro ^a   Kanzaki, Naoyuki ^a   Iizawa, Yuji ^a   Baba, Masanori ^b   Hashiguchi, Shohei ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

5 oxopyrrolidine 3 carboxamide; CCR5 antagonist; Chemokine; Human immunodeficiency virus type 1 (HIV 1)

Indexed keywords

1 BENZYL N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] 5 OXO N PHENYLPYRROLIDINE 3 CARBOXAMIDE; ANTIVIRUS AGENT; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR 5 RECEPTOR ANTAGONIST; N (3,4 DICHLOROPHENYL) N [3 [4 (4 FLUOROBENZYL)PIPERIDIN 1 YL]PROPYL] 1 METHYL 5 OXOPYRROLIDINE 3 CARBOXAMIDE; N [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] N (3,4 DICHLOROPHENYL) 1 METHYL 5 OXOPYRROLIDINE 3 CARBOXAMIDE; N [3 [4 (4 FLUOROBENZOYL)PIPERIDIN 1 YL]PROPYL] 1 METHYL 5 OXO N PHENYLPYRROLIDINE 3 CARBOXAMIDE; RANTES; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN; 5 OXOPYRROLIDINE 3 CARBOXAMIDE; 5-OXOPYRROLIDINE-3-CARBOXAMIDE; AMIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR CCR5; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG DETERMINATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; NONHUMAN; RECEPTOR AFFINITY; VIRUS ENVELOPE; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; FEMALE; HAMSTER; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDES; ANIMALS; ANTI-HIV AGENTS; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; DRUG EVALUATION, PRECLINICAL; FEMALE; HIV-1; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; PIPERIDINES; PYRROLIDINES; RANTES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2542534321     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.63     Document Type: Article

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