Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells

Molecular Endocrinology

Volumn 11, Issue 4, 1997, Pages 450-459

  Tan, Jiann An ^a   Sharief, Yousuf ^a   Hamil, Katherine G ^a   Gregory, Christopher W ^a   Zang, De Ying ^a   Sar, Madhabananda ^a   Gumerlock, Paul H ^b   DeVere White, Ralph W ^b   Pretlow, Thomas G ^d   Harris, Stephen E ^c   Wilson, Elizabeth M ^a   Mohler, James L ^a   French, Frank S ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ESTRADIOL; HYDROXYFLUTAMIDE; PRASTERONE; PROGESTERONE;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; RECEPTOR AFFINITY; RECEPTOR GENE; TRANSACTIVATION;

ANIMALIA;

EID: 8244262043     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.4.9906     Document Type: Article

References (56)

1. Horoszewicz JS, Leong SS, Kawinski E, Karr JP, Rosenthal H, Chu TM, Mirand EA, Murphy GP 1983 LNCaP model of human prostatic carcinoma. Cancer Res 43:1809-1818
2. Harris SE, Harris MA, Rong Z, Hall J, Judge S, French FS, Joseph DR, Lubahn DB, Simental JA, Wilson EM 1991 Androgen regulation of HBGF-1 (aFGF) mRNA and characterization of the androgen-receptor mRNA in the human prostate carcinoma cell line - LNCaP/A-DEP. In: Karr JP, Coffey DS, Smith RG, Tindall DJ (eds) Molecular and Cellular Biology of Prostate Cancer. Plenum Press, New York, pp 315-330
3. Harris SE, Rong Z, Harris MA, Lubahn DB, Androgen receptor in human prostate carcinoma LNCaP/ADEP cells contains a mutation which alters the specificity of the steroid-dependent transcriptional activation region. Program of the 72nd Annual Meeting of The Endocrine Society, Atlanta, GA, 1990 (Abstract 275)
4. Veldscholte J, Ris-Stalpers C, Kuiper GGJM, Jenster G, Berrevoets C, Claassen E, van Rooij HCJ, Trapman J, Brinkmann AO, Mulder E 1990 A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens. Biochem Biophys Res Commun 173:534-540
5. Newmark JR, Hardy DO, Tonb DC, Carter BS, Epstein JI, Isaacs WB, Brown TR, Barrack ER 1992 Androgen receptor gene mutations in human prostate cancer. Proc Natl Acad Sci USA 89:6319-6323
6. Culig Z, Hobisch A, Cronauer MV, Cato ACB, Hittmair A, Radmayr C, Eberle J, Bartsch G, Klocker H 1993 Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. Mol Endocrinol 7:1541-1550
7. Taplin ME, Bubley GJ, Shuster TD, Frantz ME, Spooner AE, van der Kwast TH 1995 Mutation of the androgen receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med 332:1393-1398
8. Elo JP, Kvist L, Leinonen K, Isomaa V, Henttu P, Lukkarinen O, Vihko P 1995 Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol. J Clin Endocrinol Metab 80:3494-3500
9. Tilley WD, Buchanan G, Hickey TE, Bentel JM 1996 Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence. Clin Cancer Res 2:277-285
10. Takahashi H, Furusato M, Allsbrook WC,Jr., Nishii H, Wakui S, Barrett JC, Boyd J 1995 Prevalence of androgen receptor gene mutations in latent prostatic carcinomas from Japanese men. Cancer Res 55:1621-1624
11. Gelmann EP 1996 Androgen Receptor Mutations in Prostate Cancer. In: Hait W (ed) Cancer Treatment and Research: Drug Resistance. Kluwer Academic Publishers, Norwell, MA
12. Pretlow TG, Wolman SR, Micale MA, Pelley RJ, Kursh ED, Resnick MI, Bodner DR, Jacobberger JW, Delmoro CM, Giaconia JM, Pretlow TP 1993 Xenografts of primary human prostatic carcinoma. J Natl Cancer Inst 85:394-398
13. Wainstein MA, He F, Robinson D, Kung HJ, Schwartz S, Giaconia JM, Edgehouse NL, Pretlow TP, Bodner DR, Kursh ED 1994 CWR22: Androgen-dependent xenograft model derived from a primary human prostatic carcinoma. Cancer Res 54:6049-6052
14. Gregory CW, Sharief Y, Hamil KG, Hall SH, Pretlow TG, Mohler JL, French FS 1995 Apoptosis in an androgen-dependent xenograft model derived from a primary human prostatic carcinoma. Mol Biol Cell 6:240a(Abstract)
15. Lubahn DB, Joseph DR, Sar M, Tan J, Higgs H, Larson RE, French FS, Wilson EM 1988 The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate. Mol Endocrinol 2:1265-1275
16. Lubahn DB, Brown TR, Simental JA, Higgs HN, Migeon CJ, Wilson EM, French FS 1989 Sequence of the intron/ exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity. Proc Natl Acad Sci USA 86:9534-9538
17. De Bellis A, Quigley CA, Cariello NF, El-Awady MK, Sar M, Lane MV, Wilson EM, French FS 1992 Single base mutations in the androgen receptor gene causing complete androgen insensitivity: rapid detection by a modified denaturing gradient gel electrophoresis technique. Mol Endocrinol 6:1909-1920
18. Simental JA, Sar M, Lane MV, French FS, Wilson EM 1991 Transcriptional activation and nuclear targeting signals of the human androgen receptor. J Biol Chem 266:510-518
19. Lubahn DB, Joseph DR, Sullivan PM, Willard HF, French FS, Wilson EM 1988 Cloning of human androgen receptor complementary DNA and localization to the × chromosome. Science 240:327-330
20. Dunn JF, Nisula BC, Rodbard D 1981 Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid binding globulin in human plasma. J Clin Endocrinol 53:58-68
21. Bartsch W, Klein H, Schiemann U, Bauer HW, Voigt KD 1990 Enzymes of androgen formation and degradation in the human prostate. Ann NY Acad Sci 595:53-66
22. Harper ME, Pike A, Peeling WB, Griffiths K 1974 Steroids of adrenal origin metabolized by human prostatic tissue both in vivo and in vitro. J Endocrinol 60:117-125
23. Castagnetta LA, Miceli MD, Sorci CMG, Pfeffer U, Farruggio R, Oliveri G, Calabro M, Carruba G 1995 Growth of LNCaP human prostate cancer cells is stimulated by estradiol via its own receptor. Endocrinology 136:2309-2319
24. Brolin J, Skoog L, Ekman P 1992 Immunohistochemistry and biochemistry in detection of androgen, progesterone and estrogen receptors in benign and malignant human prostatic tissue. The Prostate 20:281-295
25. Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-A 1996 Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930
26. Peterziel H, Culig Z, Stober J, Hobisch A, Radmayr C, Bartsch G, Klocker H, Cato ACB 1995 Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand binding. Int J Cancer 63:544-550
27. Wong C, Kelce WR, Sar M, Wilson EM 1995 Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J Biol Chem 270:19998-20003
28. Warriar N, Page N, Koutsilieris M, Govindan MV 1993 Interaction of antiandrogen-androgen receptor complexes with DNA and transcription activation. J Steroid Biochem 46:699-711
29. Kemppainen JA, Wilson EM 1996 Agonist and antagonist activities of hydroxyflutamide and casodex relate to androgen receptor stabilization. Urology 48:157-163
30. Scher HI, Kelly WK 1993 Flutamide withdrawal syndrome: its impact on clinical trials in hormone-refractory prostate cancer. J Clin Oncol 11:1566-1572
31. Sartor O, Cooper M, Wienberger M, Headlee D, Thibault A, Tompkins A, Steinberg S, Figg WD, Linehan WM, Myers CE 1994 Surprising activity of flutamide withdrawal when combined with aminoglutethimide, in treatment of "hormone-refractory" prostate cancer. J Natl Cancer Inst 86:222-227
32. Wilding G, Chen M, Gelmann EP 1989 Aberrant response in vitro of hormone-responsive prostate cancer cells to antiandrogens. The Prostate 14:103-115
33. Schuurmans ALG, Bolt J, Voorhorst MM, Blankenstein RA, Mulder E 1988 Regulation of growth and epidermal growth factor receptor levels of LNCaP prostate tumor cancer cells by different steroids. Int J Cancer 42:917-922
34. Olea N, Sakabe K, Soto AM, Sonnenschein C 1990 The proliferative effect of "anti-androgens" on the androgen sensitive human prostate tumor cell line LNCaP. Endocrinology 126:1457-1463
35. Kokontis J, Ito K, Hiipakka RA, Liao S 1991 Expression and function of normal and LNCaP androgen receptors in androgen-insensitive human prostatic cancer cells. Receptor 1:271-279
36. Veldscholte J, Voorhorst-Ogink MM, Bole-de Vries J, van Rooij HCJ, Trapman J, Mulder E 1990 Unusual specificity of the androgen receptor in the human prostate tumor cell line LNCaP: high affinity for progestagenic and estrogenic steroids. Biochim Biophys Acta 1052:187-194
37. Lee C, Sutkowski DM, Sensibar JA, Zelner D, Kim I, Amsel I, Shaw N, Prins GS, Kozlowski JM 1995 Regulation of proliferation and production of prostate-specific antigen in androgen-sensitive prostatic cancer cells, LNCaP, by dihydrotestosterone. Endocrinology 136: 796-803
38. Quigley CA, De Bellis A, Marschke KB, El-Awady MK, Wilson EM, French FS 1995 Androgen receptor defects: historical, clinical, and molecular perspectives. Endocr Rev 16:271-321
39. 24 18) in the androgen receptor gene in human prostate cancer. Biochem Biophys Res Commun 198:74-80
40. Lamb D, Sutherland R, Nazareth L, Mariani S, DeMayo J, Weigel N, Marcelli M, Deconcini D 1996 Androgen receptor mutations in advanced prostate cancer. In: Breast and Prostate Cancer: Basic Mechanisms. Keystone Symposium, Taos, NM (Abstract 205)
41. Wagner RL, Apriletti JW, McGrath ME, West BL, Baxter JD, Fletterick RJ 1995 A structural role for hormone in the thyroid hormone receptor. Nature 378:690-697
42. Wurtz J, Bourguet W, Renaud J, Vivat V, Chambon P, Moras D, Gronemeyer H 1996 A canonical structure for the ligand-binding domain of nuclear receptors. Nat Struct Biol 3:87-94
43. Brown TR, Lubahn DB, Wilson EM, French FS, Migeon CJ, Corden JL 1990 Functional characterization of naturally occurring mutant androgen receptors from subjects with complete androgen insensitivity. Mol Endocrinol 4:1759-1772
44. van der Kwast TH, Schalken J, Ruizeveld de Winter JA, Van Vroonhoven CCJ, Mulder E, Boersma W, Trapman J 1991 Androgen receptors in endocrine therapy resistant human prostate cancer. Int J Cancer 48:189-193
45. deVere White R, Meyers FJ, Chi SG, Chamberlain S, Siders D, Lee F, Stewart S, Gumerlock PH 1997 Human androgen receptor expression in prostate cancer following androgen ablation. Eur Urol 31:1-6
46. Culig Z, Hobisch A, Cronauer MV, Radmayr C, Trapman J, Hittmair A, Bartsch G, Klocker H 1994 Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res 54:5474-5478
47. Nazareth LV, Weigel NL 1996 Activation of the human androgen receptor through a protein kinase A signaling pathway. J Biol Chem 271:19900-19907
48. Robinson D, He F, Pretlow T, Kung H 1996 A tyrosine kinase profile of prostate carcinoma. Proc Natl Acad Sci USA 93:5958-5962
49. Quarmby VE, Kemppainen JA, Sar M, Lubahn DB, French FS, Wilson EM 1990 Expression of recombinant androgen receptor in cultured mammalian cells. Mol Endocrinol 4:1399-1407
50. Miyamoto KK, McSherry SA, Dent GA, Sar M, Wilson EM, French FS, Sharief Y, Mohler JL 1993 Immunohistochemistry of the androgen receptor in human benign and malignant prostate tissue. J Urol 149:1015-1019
51. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ 1979 Isolation of biologically active RNA from sources enriched in ribonuclease. Biochemistry 18:5294-5299
52. Quarmby VE, Yarbrough WG, Lubahn DB, French FS, Wilson EM 1990 Autologous down-regulation of androgen receptor messenger ribonucleic acid. Mol Endocrinol 4:22-28
53. Gumerlock PH, Tang YJ, Meyers FJ, Silva J,Jr. 1991 Use of the polymerase chain reaction for the specific and direct detection of Clostridium difficile in human feces. Rev Infect Dis 13:1053-1060
54. Israeli RS, Miller WH, Su SL, Powell CT, Fair WR, Samandi DS, Huryk RF, DeBlasio A, Edwards ET, Wise GJ, Heston WDW 1994 Sensitive nested reverse transcription polymerase chain reaction detection of circulating prostatic tumor cells: comparison of prostate-specific membrane antigen and prostate-specific antigen-based assays. Cancer Res 54:6306-6310
55. Fishman JR, Gumerlock PH, Meyers FJ, deVere White R 1994 Quantitation of NM23 expression in human prostate tissues. J Urol 152:202-207
56. Tan J-A, Marschke KB, Ho K-C, Perry ST, Wilson EM, French FS 1992 Response elements of the androgen-regulated C3 gene. J Bio Chem 267:4456-4466