Synthesis of novel 21-trifluoropregnane steroids: Inhibitors of 17α- hydroxylase/17,20-1yase (17α-lyase)

Steroids

Volumn 62, Issue 6, 1997, Pages 468-473

  Njar, Vincent C O ^a,b   Klus, Gregory T ^a   Johnson, Hausa H ^a   Brodie, Angela M H ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Inhibitor of 17 hydroxylase 17,20 lyase; Synthesis

Indexed keywords

21 TRIFLUOROPREGNENOLONE; 21 TRIFLUOROPROGESTERONE; 3BETA ACETOXYANDROST 5 ENE 17BETA CARBALDEHYDE; CYTOCHROME P450; STEROID 17ALPHA MONOOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME INHIBITION; HORMONE ACTION; HYDROLYSIS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; STEROID METABOLISM; STEROIDOGENESIS;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; PREGNANES; PREGNENES; RATS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STEROID 17-ALPHA-HYDROXYLASE;

EID: 0030927680     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(97)00016-0     Document Type: Article

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