A new class of nonsteroidal aromatase inhibitors: Design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17α-hydroxylase/C17,20-lyase

Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2001, Pages 672-680

  Recanatini, M ^a   Hartmann, R W ^a   Bisi, A ^a   Cavalli, A ^a   Belluti, F ^a   Gobbi, S ^a   Rampa, A ^a   Valenti, P ^b   Palzer, M ^b   Palusczak, A ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANASTROZOLE; ANDROGEN; AROMATASE; AROMATASE INHIBITOR; CHROMONE DERIVATIVE; CYTOCHROME P450; FADROZOLE; FLAVONE DERIVATIVE; IMIDAZOLE; LETROZOLE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; TESTOSTERONE; TRITIUM; VOROZOLE; XANTHONE DERIVATIVE;

ARTICLE; BREAST CANCER; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; MICROSOME; PROSTATE DISEASE; STRUCTURE ACTIVITY RELATION;

AROMATASE INHIBITORS; CHROMONES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MALE; MICROSOMES; MODELS, MOLECULAR; PLACENTA; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS; XANTHENES; XANTHONES;

EID: 84872647271     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000955s     Document Type: Article

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