The pre-BCR checkpoint as a cell-autonomous proliferation switch

Trends in Immunology

Volumn 25, Issue 5, 2004, Pages 249-256

  Hendriks, Rudi W ^a   Middendorp, Sabine ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; BRUTON TYROSINE KINASE; IMMUNOGLOBULIN HEAVY CHAIN; INTERLEUKIN 7 RECEPTOR; PRE B LYMPHOCYTE RECEPTOR; PROTEIN; PROTEIN SLP 65; UNCLASSIFIED DRUG;

ALLELE; CELL MATURATION; GENE TARGETING; HUMAN; LYMPHOCYTE PROLIFERATION; NONHUMAN; PHENOTYPE; PRE B LYMPHOCYTE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; B-LYMPHOCYTES; CARRIER PROTEINS; CELL DIVISION; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN SWITCH REGION; LEUKEMIA, PRE-B-CELL; LYMPHOCYTE ACTIVATION; LYMPHOMA, B-CELL; MICE; MICE, KNOCKOUT; MODELS, IMMUNOLOGICAL; MULTIENZYME COMPLEXES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, INTERLEUKIN-7; SIGNAL TRANSDUCTION;

EID: 11144247047     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2004.02.011     Document Type: Review

References (80)

1. Hardy R.R. B-cell commitment: deciding on the players. Curr. Opin. Immunol. 15:2003;158-165.
2. Meffre E., et al. Antibody regulation of B cell development. Nat. Immunol. 1:2000;379-385.
3. Niiro H., Clark E.A. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2:2002;945-956.
4. Grawunder U., et al. Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity. 3:1995;601-608.
5. Ohnishi K., Melchers F. The non-immunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling. Nat. Immunol. 4:2003;849-856.
6. Flemming A., et al. The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat. Immunol. 4:2003;38-43.
7. Kersseboom R., et al. Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in pre-B cells. J. Exp. Med. 198:2003;91-98.
8. Hayashi K., et al. Distinct signaling requirements for Dμ selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors. Immunity. 18:2003;825-836.
9. Guo B., et al. Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex. Immunity. 13:2000;243-253.
10. Kouro T., et al. Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition. Int. Immunol. 13:2001;485-493.
11. Rolli V., et al. Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop. Mol. Cell. 10:2002;1057-1069.
12. Tretter T., et al. Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk. J. Exp. Med. 198:2003;1863-1873.
13. Kurosaki T. Regulation of B-cell signal transduction by adaptor proteins. Nat. Rev. Immunol. 2:2002;354-363.
14. Middendorp, S. et al. Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity. J. Immunol. 171, 5988-5996.
15. 2 synthesis: importance for calcium signaling and PI3K activity. Immunity. 19:2003;669-678.
16. Schebesta M., et al. Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene. Immunity. 17:2002;473-485.
17. Saijo K., et al. Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development. Nat. Immunol. 4:2003;274-279.
18. Iritani B.M., et al. Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors. Immunity. 10:1999;713-722.
19. Shaw A.C., et al. Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras. Proc. Natl. Acad. Sci. U. S. A. 96:1999;2239-2243.
20. Nagaoka H., et al. Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage. J. Exp. Med. 192:2000;171-182.
21. Gauthier L., et al. Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering. Proc. Natl. Acad. Sci. U. S. A. 99:2002;13014-13019.
22. Bradl H., Jack H.M. Surrogate light chain-mediated interaction of a soluble pre-B cell receptor with adherent cell lines. J. Immunol. 167:2001;6403-6411.
23. Rolink A.G., et al. Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment. J. Exp. Med. 191:2000;23-32.
24. Bradl H., et al. Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of λ5 and stroma cell-associated heparan sulfate. J. Immunol. 171:2003;2338-2348.
25. Shaffer A.L., Schlissel M.S. A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development. J. Immunol. 159:1997;1265-1275.
26. Muljo S.A., Schlissel M.S. The variable, C(H)1, C(H)2 and C(H)3 domains of Ig heavy chain are dispensable for pre-BCR function in transgenic mice. Int. Immunol. 14:2002;577-584.
27. Schweighoffer E., et al. Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. Immunity. 18:2003;523-533.
28. Middendorp, S. and Hendriks, R.W. (2004) Cellular maturation defects in Bruton's tyrosine kinase-deficient immature B cells are amplified by premature B cell receptor expression and reduced by receptor editing. J. Immunol. 172, 1371-1379.
29. Caldwell R.G., et al. Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity. 9:1998;405-411.
30. Bannish G., et al. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J. Exp. Med. 194:2001;1583-1596.
31. Kitamura D., Rajewsky K. Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature. 356:1992;154-156.
32. Nussenzweig M.C., et al. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin μ Science. 236:1987;816-819.
33. Papavasiliou F., et al. The cytoplasmic domains of immunoglobulin (Ig) α and Ig β can independently induce the precursor B cell transition and allelic exclusion. J. Exp. Med. 182:1995;1389-1394.
34. Gong S., Nussenzweig M.C. Regulation of an early developmental checkpoint in the B cell pathway by Ig β Science. 272:1996;411-414.
35. Macpherson A.J., et al. IgA production without μ or δ chain expression in developing B cells. Nat. Immunol. 2:2001;625-631.
36. Kitamura D., et al. A critical role of λ5 protein in B cell development. Cell. 69:1992;823-831.
37. Shimizu T., et al. VpreB1/VpreB2/λ 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. J. Immunol. 168:2002;6286-6293.
38. Pelanda R., et al. B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-α and Ig-β J. Immunol. 169:2002;865-872.
39. Reichlin A., et al. B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin β J. Exp. Med. 193:2001;13-23.
40. Kraus M., et al. Interference with immunoglobulin (Ig)α immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igβ cytoplasmic tail. J. Exp. Med. 194:2001;455-469.
41. Khan W.N., et al. Defective B cell development and function in Btk-deficient mice. Immunity. 3:1995;283-299.
42. Jumaa H., et al. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity. 11:1999;547-554.
43. Pappu R., et al. Requirement for B cell linker protein (BLNK) in B cell development. Science. 286:1999;1949-1954.
44. Xu S., et al. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice. Int. Immunol. 12:2000;397-404.
45. Hayashi K., et al. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells. Proc. Natl. Acad. Sci. U. S. A. 97:2000;2755-2760.
46. Jumaa H., et al. The absence of SLP65 and Btk blocks B cell development at the preB cell receptor-positive stage. Eur. J. Immunol. 31:2001;2164-2169.
47. Middendorp S., et al. Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice. J. Immunol. 168:2002;2695-2703.
48. Jumaa H., et al. Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia. Nature. 423:2003;452-456.
49. Goodman P.A., et al. Defective expression of Bruton's tyrosine kinase in acute lymphoblastic leukemia. Leuk. Lymphoma. 44:2003;1011-1018.
50. Minegishi Y., et al. An essential role for BLNK in human B cell development. Science. 286:1999;1954-1957.
51. Nomura K., et al. Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway. Blood. 96:2000;610-617.
52. Wong J., et al. Functional complementation of BLNK by SLP-76 and LAT linker proteins. J. Biol. Chem. 275:2000;33116-33122.
53. Ishiai M., et al. Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane. J. Exp. Med. 192:2000;847-856.
54. Su Y., Jumaa H. LAT links the pre-BCR to calcium signaling. Immunity. 19:2003;295-305.
55. Oya K., et al. Appearance of the LAT protein at an early stage of B-cell development and its possible role. Immunology. 109:2003;351-359.
56. Ellmeier W., et al. Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. J. Exp. Med. 192:2000;1611-1624.
57. Hoffmann R., et al. Changes in gene expression profiles in developing B cells of murine bone marrow. Genome Res. 12:2002;98-111.
58. Dingjan G.M., et al. Bruton's tyrosine kinase regulates the activation of gene rearrangements at the λ light chain locus in precursor B cells in the mouse. J. Exp. Med. 193:2001;1169-1178.
59. Lu R., et al. IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes Dev. 17:2003;1703-1708.
60. Muljo S.A., Schlissel M.S. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat. Immunol. 4:2003;31-37.
61. Xu S., Lam K.P. Delayed cellular maturation and decreased immunoglobulin κ light chain production in immature B lymphocytes lacking B cell linker protein. J. Exp. Med. 196:2002;197-206.
62. Carsetti R. The development of B cells in the bone marrow is controlled by the balance between cell-autonomous mechanisms and signals from the microenvironment. J. Exp. Med. 191:2000;5-8.
63. Fleming H.E., Paige C.J. Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection. Semin. Immunol. 14:2002;423-430.
64. Marshall A.J., et al. Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. J. Immunol. 161:1998;6038-6045.
65. Fleming H.E., Paige C.J. Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. Immunity. 15:2001;521-531.
66. Smart F.M., Venkitaraman A.R. Inhibition of interleukin 7 receptor signaling by antigen receptor assembly. J. Exp. Med. 191:2000;737-742.
67. Pelanda R., et al. A prematurely expressed Ig(κ) transgene, but not V(κ)J(κ) gene segment targeted into the Ig(κ) locus, can rescue B cell development in λ5-deficient mice. Immunity. 5:1996;229-239.
68. Mielenz D., et al. Immunoglobulin micro heavy chains do not mediate tyrosine phosphorylation of Igα from the ER-cis-Golgi. J. Immunol. 171:2003;3091-3101.
69. Minegishi Y., Conley M.E. Negative selection at the pre-BCR checkpoint elicited by human μ heavy chains with unusual CDR3 regions. Immunity. 14:2001;631-641.
70. Schuh W., et al. Cutting edge: signaling and cell surface expression of a micro H chain in the absence of λ5: a paradigm revisited. J. Immunol. 171:2003;3343-3347.
71. Su Y.W., et al. Identification of a pre-BCR lacking surrogate light chain. J. Exp. Med. 198:2003;1699-1706.
72. Karasuyama H., et al. A complex of glycoproteins is associated with VpreB/λ 5 surrogate light chain on the surface of μ heavy chain-negative early precursor B cell lines. J. Exp. Med. 178:1993;469-478.
73. Ohnishi K., et al. The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain. J. Biol. Chem. 275:2000;31134-31144.
74. Nagata K., et al. The Ig α/Igβ heterodimer on μ-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity. 7:1997;559-570.
75. Gu H., et al. B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D μ protein and selection of DH element reading frames. Cell. 65:1991;47-54.
76. Horne M.C., et al. Assembly of the truncated immunoglobulin heavy chain Dμ into antigen receptor-like complexes in pre-B cells but not in B cells. Immunity. 4:1996;145-158.
77. Tornberg U.C., et al. Regulation of B lymphocyte development by the truncated immunoglobulin heavy chain protein Dμ J. Exp. Med. 187:1998;703-709.
78. Loffert D., et al. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity. 4:1996;133-144.
79. Chowdhury D., Sen R. Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements. Immunity. 18:2003;229-241.
80. Gong S., et al. Counterselection against Dμ is mediated through immunoglobulin (Ig)α-Igβ J. Exp. Med. 184:1996;2079-2084.