Secondary amide-based linkers for solid phase organic synthesis

Tetrahedron Letters

Volumn 38, Issue 49, 1997, Pages 8465-8468

  Swayze, Eric E ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; BENZALDEHYDE DERIVATIVE;

AMINATION; ARTICLE; DERIVATIZATION; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 0030680993     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10281-7     Document Type: Article

References (24)

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16. 13C NMR. The yield was assumed to be quantitative based upon the stated loading of the resin if all starting material had disappeared, and only products were evident.
17. 3P solution is avoided.
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24. In our initial library synthesis efforts employing this linkage strategy, we have prepared bi-functional amines, and used them to construct small heterocycles having combinatorial sites. These studies will be reported in due course.