Synthesis of an elaborated heliquinomycin isocoumarin moiety

Tetrahedron Letters

Volumn 41, Issue 1, 2000, Pages 29-31

  Thrash, Thomas P ^a   Welton, Thomas D ^a   Behar, Victor ^a  

^a RICE UNIVERSITY   (United States)

Author keywords

Antitumor; Antitumor compounds; Condensations; Isocoumarins; Rearrangements

Indexed keywords

ANTINEOPLASTIC AGENT; ETHER; HELIQUINOMYCIN ISOCOUMARIN; ISOCOUMARIN DERIVATIVE; MALONIC ACID DERIVATIVE; PHTHALALDEHYDE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; ESTERIFICATION; PARTIAL DRUG SYNTHESIS; POLYMERIZATION;

EID: 0033992257     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01966-8     Document Type: Article

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14. The monoallylated product was only partially stable to chromatography and could not be separated from starting material without significant material losses due to decomposition. However, the mixture obtained from monoallylation could be carried forward directly without reduction in yield through the next two steps (as compared to using purified monoallylated starting material).