Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP-binding cassette (ABC) drug transporters

Biochemical Pharmacology

Volumn 67, Issue 6, 2004, Pages 1111-1121

  Dantzig, Anne H ^a   Shepard, Robert L ^a   Pratt, Susan E ^a   Tabas, Linda B ^a   Lander, Peter A ^a   Ma, Liandong ^a   Paul, Donald C ^a   Williams, Daniel C ^a   Peng, Sheng Bin ^a   Slapak, Christopher A ^a   Godinot, Nathalie ^a   Perry III, William L ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

ABC; ATP binding cassette; BCRP; Breast cancer resistance protein; DOX; Doxorubicin; EC50; FBS; Fetal bovine serum; G418; Geneticin; Glutathione; GSH; Leukotriene C4; LTC4; The concentration that gives 50 of the maximal response

Indexed keywords

ABC TRANSPORTER; ANTHRACYCLINE; BREAST CANCER RESISTANCE PROTEIN; DOXORUBICIN; GLYCOPROTEIN P; ISOXAZOLE DERIVATIVE; LEUKOTRIENE C4; LY 465803; LY 475776; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 5; RS 335979 198; UNCLASSIFIED DRUG; VERLUKAST; VINCRISTINE; ZOSUQUIDAR;

ARTICLE; BINDING SITE; CELL LINE; CELL MEMBRANE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SPECIFICITY; HUMAN; HUMAN CELL; ORTHOLOGY; PHOTOAFFINITY LABELING; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; AZIDES; CELL DIVISION; DRUG RESISTANCE, MULTIPLE; HELA CELLS; HUMANS; ISOXAZOLES; MICE; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PHOTOAFFINITY LABELS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 10744220447     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.11.006     Document Type: Article

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