Folate levels determine effect of antioxidant supplementation on micronuclei in subjects with cardiovascular risk

Mutagenesis

Volumn 19, Issue 6, 2004, Pages 469-476

  Smolkova B ^a   Dusinska M ^a   Raslova K ^a   Barancokova M ^a   Kazimirova A ^a   Horska A ^a   Spustova V ^a   Collins, A ^b  

^a SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; FERRIC ION; FOLIC ACID; HOMOCYSTEINE; MALONALDEHYDE; PLACEBO; SELENIUM;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CHROMOSOME DAMAGE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; GENETIC DAMAGE; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MICRONUCLEUS; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

ALPHA-TOCOPHEROL; ANTIOXIDANTS; ASCORBIC ACID; BETA CAROTENE; CARDIOVASCULAR DISEASES; DIETARY SUPPLEMENTS; DNA DAMAGE; FOLIC ACID; FOLIC ACID DEFICIENCY; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICRONUCLEUS TESTS; MIDDLE AGED; MYOCARDIAL INFARCTION; OXIDATIVE STRESS; SELENIUM;

EID: 10044261130     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/geh059     Document Type: Article

References (75)

1. Andreassi, M.G. (2003) Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage. Mutat. Res., 543, 67-86.
2. Andreassi, M.G. and Botto, N. (2003) DNA damage as a new emerging risk factor in atherosclerosis. Trends Cardiovasc. Med., 13, 270-275.
3. Andreassi, M.G., Botto, N., Colombo, M.G., Biagini, A. and Clerico, A. (2000) Genetic instability and atherosclerosis: can somatic mutations account for the development of cardiovascular diseases? Environ. Mol. Mutagen., 35, 265-269.
4. Andreassi, M.G., Botto, N., Cocci, F. et al. (2003) Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12 and DNA damage in coronary artery disease. Hum. Genet., 112, 171-177.
5. Benzie, I.F. and Strain, J.J. (1996) The ferric reducing activity of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Anal. Biochem., 239, 70-76.
6. Berliner, J.A., Navab, M., Fogelman, A.M., Frank, J.S., Demer, L.L., Edwards, P.A., Watson, A.D. and Lusis, A.J. (1995) Atherosclerosis: basic mechanisms - oxidation, inflammation and genetics. Circulation, 91, 2488-2496.
7. Blount, B.C. and Ames, B.N. (1995) DNA damage in folate deficiency. Baillieres Clin. Haematol., 8, 461-478.
8. Blount, B.C., Mack, M.M., Wehr, C.M., MacGregor, J.T., Hiatt, R.A., Wang, G., Wickramasinghe, S.N., Everson, R.B. and Ames, B.N. (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl Acad. Sci. USA, 94, 3290-3295.
9. Bonassi, S., Neri, M., Lando, C. et al. (2003) HUMN collaborative group. Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project. Mutat. Res., 543, 155-166.
10. Botto, N., Rizza, A., Colombo, M.G., Mazzone, A.M., Manfredi, S., Masetti, S., Clerico, A., Biagini, A. and Andreassi, M.G. (2001) Evidence for DNA damage in patients with coronary artery disease. Mutat. Res., 493, 23-30.
11. Botto, N., Andreassi, M.G., Manfredi, S., Masetti, S., Cocci, F., Colombo, M.G., Storti, S., Rizza, A. and Biagini, A. (2003) Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage. Eur. J. Hum. Genet., 11, 671-678.
12. Boushey, C.J., Beresford, S.A., Omenn, G.S. and Motulsky, A.G. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing of folic acid intakes. J. Am. Med. Assoc., 274, 1049-1057.
13. Brattstrom, L., Wilcken, D.E., Ohrvik, J. and Brudin, L. (1998) Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation, 98, 2520-2526.
14. Brown, T.A. (1995) Essential Molecular Biology: A Practical Approach, Vol. 1. Oxford University Press, Oxford, pp. 50-53.
15. Chambers, J.C., McGregor, A., Jean-Marie, J. and Kooner, J.S. (1998) Acute hyperhomocysteinaemia and endothelial dysfunction. Lancet, 351, 36-37.
16. Chambers, J.C., Obeid, O.A. and Kooner, J.S. (1999) Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects. Arterioscler. Thromb. Vasc. Biol., 19, 2922-2927.
17. Chasan-Taber, L., Selhub, J., Rosenberg, I.H., Malinow, M.R., Terry, P., Tishler, P.V., Willet, W., Hennekens, C.H. and Stampfler, M.J. (1996) A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians. J. Am. Coll. Nutr., 15, 136-143.
18. Costello, J.F. and Plass, C. (2001) Methylation matters. J. Med. Genet., 38, 285-303.
19. Crott, J. and Fenech, M. (2001) Preliminary study of the genotoxic potential of homocysteine in human lymphocytes in vitro. Mutagenesis, 16, 213-217.
20. Crott, J.W., Mashiyama, S.T., Ames, B.N. and Fenech, M.F. (2001) Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. Carcinogenesis, 22, 1019-1025.
21. De Bree, A., Verschuren, W.M., Bjorke-Monsen, A.L., van der Put, N.M., Heil, S.G., Trijbels, F.J. and Blom, H.J. (2003) Effect of the methylenetetrahydrofolate reductase 677C → T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Am. J. Clin. Nutr., 77, 687-693.
22. Dušinská, M., Vallová, B., Ursinyová, M., Hladíková, V., Smolková, B., Wsolová, L., Rašlová, K. and Collins, A.R. (2002) DNA damage and antioxidants: fluctuation through the year in a central European population group. Food Chem. Toxicol., 40, 1119-1123.
23. Dušinská, M., Kazimírová, A., Barančoková, M., Beño, M., Rašlová, K., Smolková, B., Horská, A., Wsolová, L. and Collins, A.R. (2003) Nutritional supplementation with antioxidants decreases chromosomal damage in humans. Mutagenesis, 18, 371-376.
24. Eikelboom, J.W., Lonn, E., Genest, J., Jr, Hankey, G. and Yusuf, S. (1999) Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann. Intern. Med., 131, 363-375.
25. Fenech, M. (1993) The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat. Res., 285, 35-44.
26. Fenech, M. (2001) The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat. Res., 475, 57-67.
27. Fenech, M. (2002) Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDSa). Food Chem. Toxicol., 40, 1113-1117.
28. Fenech, M. (2004) Genome health nutrigenomics: nutrition and the science of optimal genome maintenance. Asia Pac. J. Clin. Nutr., 13 (suppl.), S15.
29. Fenech, M. and Morley, A.A. (1985) Measurement of micronuclei in lymphocytes. Mutat. Res., 147, 29-36.
30. Fenech, M., Dreosti, I. and Aitken, C. (1997a) Vitamin-E supplements and their effect on vitamin-E status in blood and genetic damage rate in peripheral blood lymphocytes. Carcinogenesis, 18, 359-364.
31. Fenech, M.F., Dreosti, I.E. and Rinaldi, J.R. (1997b) Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis, 18, 1329-1336.
32. Fenech, M., Aitken, C. and Rinaldi, J. (1998) Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis, 19, 1163-1171.
33. Friedewald, W.T., Levy, R.I. and Frederickson, D.S. (1972) Estimation of the concentration for low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem., 18, 499-502.
34. Friso, S., Choi, S.W., Girelli, D. et al. (2002) A common mutation in the 5, 10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc. Natl Acad. Sci. USA, 99, 5606-5611.
35. Gaziev, A.I., Sologub, G.R., Fomenko, L.A., Zaichkina, S.I., Kosyakova, N.I. and Bradbury, R.J. (1996) Effect of vitamin-antioxidant micronutrients on the frequency of spontaneous and in vitro gamma-ray-induced micronuclei in lymphocytes of donors: the age factor. Carcinogenesis, 17, 493-499.
36. Goyette, P., Sumner J.S., Milos, R., Duncan, A.M., Rosenblatt, D.S., Matthews, R.G. and Rozen, R. (1994) Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nature Genet., 7, 195-200.
37. Hess, D., Keller, H.E., Oberlin, B., Bonfanti, R. and Schuep, W. (1991) Simultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high performance liquid chromatography on reversed phase. Int. J. Vitam. Nutr. Res., 61, 232-238.
38. Jacques, P.F., Bostom, A.G., Williams, R.R., Ellison, R.C., Eckfeldt, J.H., Rosenberg, I.H., Selhub, J. and Rozen, R. (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase and plasma homocysteine concentrations. Circulation, 93, 7-9.
39. Kimura, M., Umegaki, K., Higuchi, M., Thomas, P. and Fenech, M. (2004) Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J. Nutr., 134, 8-56.
40. Klerk, M., Verhoef, P., Clarke, R., Blom, H.J., Kok, F.J. and Schouten, E.G. (2002) MTHFR Studies Collaboration Group. MTHFR 677C-T polymorphism and risk of coronary heart disease: a meta-analysis. J. Am. Med. Assoc., 288, 2023-2031.
41. Kluijtmans, L.A., van den Heuvel, L.P., Boers, G.H. et al. (1996) Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am. J. Hum. Genet., 58, 35-41.
42. Kluijtmans, L.A., Kastelein, J.J., Lindemans, J. et al. (1997) Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation, 96, 2573-2577.
43. Kruman, I.I., Culmsee, C., Chan, S.L., Kruman, Y., Guo, Z., Penix, L. and Mattson, M.P. (2000) Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci., 20, 6920-6926.
44. Loria, C.M., Ingram, D.D., Fekdman, J.J., Wright, J.D. and Madans, J.H. (2000) Serum folate and cardiovascular disease mortality among US men and women. Arch. Int. Med., 160, 3258-3262.
45. Ma, J., Stampfer, M.J., Hennekens, C.H., Frosst, P., Selhub, J., Horsford, J., Malinow, M.R., Willett, W.C. and Rozen, R. (1996) Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine and risk of myocardial infarction in US physicians. Circulation, 94, 2410-2416.
46. Mattson, M.P., Kruman, I.I. and Duan, W. (2002) Folic acid and homocysteine in age-related disease. Ageing Res. Rev., 1, 95-111.
47. Mayer, E.L., Jacobsen, D.W. and Robinson, K. (1996) Homocysteine and coronary atherosclerosis. J. Am. Coll. Cardiol., 27, 517-527.
48. Moat, S.J., Lang, D., McDowell, J.F., Clarke, Z.L., Madhavan, A.K., Lewis, M.J., and Goodfellow, J. (2004) Folate, homocysteine, endothelial function and cardiovascular disease. J. Nutr. Biochem., 15, 64-79.
49. Morita, H., Taguchi, J., Kuruhari, H. et al. (1997) Genetic polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation, 95, 2032-2036.
50. Oikawa, S., Murakami, K. and Kawanishi, S. (2003) Oxidative damage to cellular and isolated DNA by homocysteine: implications for carcinogenesis. Oncogene, 22, 3530-3538.
51. Omenn, G.S. (1998) Chemoprevention of lung cancer: the rise and demise of beta-carotene. Annu. Rev. Public Health, 19, 73-99.
52. Paz, M.F., Avila, S., Fraga, M.F., Pollan, M., Capella, G., Peinado, M.A., Sanchez-Cespedes, M., Herman, J.G. and Esteller, M. (2002) Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res., 62, 4519-4524.
53. Rašlová, K., Bederová, A., Gašparovič, J., Blažíček, P. and Smolková, B. (2000) Effect of diet and 677 C → T 5,10-methylenetetrahydrofolate reductase genotypes on plasma homocyst(e)ine concentrations in Slovak adolescent population. Physiol. Res., 49, 651-658.
54. Rašlová, K., Smolková, B., Vohnout, B., Gašparovič, J. and Frohlich, J.J. (2001) Risk factors for atherosclerosis in survivors of myocardial infarction and their spouses: comparison to controls without personal and family history of atherosclerosis. Metabolism, 50, 24-29.
55. Record, I.R. and Jannes, M. (2000) Iron, alpha-tocopherol, oxidative damage and micronucleus formation in rat splenocytes. Cancer Lett., 160, 125-131.
56. Richard, M.J., Giraud, P., Meo, J. and Favier, A. (1992) High performance liquid separation of malondialdehyde-thiobarbituric acid adducts in biological materials (plasma and human cells) using a commercially available reagent. J. Chromatogr., 577, 9-18.
57. Robinson, K., Arheart, K., Refsum, H. et al. (1998) Low circulating folate and vitamin B6 concentrations: risk factor for stroke, peripheral vascular disease and coronary artery disease: European COMAC Group. Circulation, 97, 437-443.
58. Ross, M.A. (1994) Determination of ascorbic acid and uric acid in plasma by high performance liquid chromatography. J. Chromatogr., 657, 197-200.
59. Schmitz, C., Lindpaintner, K., Verhoef, P., Gaziano, J.M. and Buring, J. (1996) Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction: a case control study. Circulation, 94, 1812-1814.
60. Schneider, M., Diemer, K., Engelhart, K., Zankl, H., Trommer, W.E. and Biesalski, H.K. (2001) Protective effects of vitamins C and E on the number of micronuclei in lymphocytes in smokers and their role in ascorbate free radical formation in plasma. Free. Radic. Res., 34, 209-219.
61. Schwartz, S.M., Siscovick, D.S., Malinow, M.R. et al. (1997) Myocardial infarction in young women in relation to plasma total homocysteine, folate and a common variant in the methylenetetrahydrofolate reductase gene. Circulation, 96, 412-417.
62. Smolková, B., Dušinská, M., Rašlová, K., McNeill, G., Spustová, V., Blažíček, P., Horská, A. and Collins, A. (2004) Seasonal changes in markers of oxidative damage to lipids and DNA; correlations with seasonal variation in diet. Mutat. Res., 551, 135-144.
63. Tall, A., Welch, C., Applebaum-Bowden, D. and Wassef, M. (1997) Interaction of diet and genes in atherogenesis. Report of an NHLBI working group. Arterioscler. Thromb. Vasc. Biol., 17, 3326-3331.
64. Tawakol, A., Omland, T., Gerhard, M., Wu, J.T. and Creager, M.A. (1997) Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation, 95, 1119-1121.
65. Titenko-Holland, N., Jacob, R.A., Shang, N., Balaraman, A. and Smith, M.T. (1998) Micronuclei in lymphocytes and exfoliated buccal cells of postmenopausal women with dietary changes in folate. Mutat. Res., 417, 101-114.
66. Tsai, J.C., Perrella, M.A., Yoshizumi, M., Hsieh, C.M., Haber, E., Schlegel, R. and Lee, M.E. (1994) Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc. Natl Acad. Sci. USA, 91, 6369-9373.
67. Ursínyová, M. and Hladíková, V. (1998) Determination of selenium in serum using atomic absorption spectrometry. Chemické Listy, 92, 495-498.
68. Van Bockxmeer, F.M., Mamotte, C.D.S., Vasikaran, S.D. and Taylor, R.R. (1997) Methylenetetrahydrofolate reductase gene and coronary artery disease. Circulation, 95, 21-23.
69. Van Poppel, G., Kok, F.J. and Hermus, R.J. (1992) Beta-carotene supplementation in smokers reduces the frequency of micronuclei in sputum. Br. J. Cancer, 66, 1164-1168.
70. Verhaar, M.C., Stroes, E. and Rabelink, T.J. (2002) Folates and cardiovascular disease. Arterioskler. Thromb. Vasc. Biol., 22, 6-13.
71. Verhaar, M.C., Wever, R.M.F., Kastelein, J.J.P., van Dam, T., Koomans, H.A. and Rabelink, T.J. (1998) 5-Methyltetrahydrofolate, the active form of folic acid, improves endothelial function in familial hypercholesterolemia. Circulation, 100, 335-338.
72. Vester, B. and Rasmussen, K. (1991) High performance liquid chromatography method for rapid and accurate determination of homocyst(e)ine in plasma and serum. Eur. J. Clin. Chem. Clin. Biochem., 29, 549-554.
73. Voutilainen, S., Lakka, T.A., Porkkala-Sarataho, E., Rissanen, T., Kaplan, G.A. and Salonen, J.T. (2000) Low serum folate concentrations are assocated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Eur. J. Clin. Nutr., 54, 424-428.
74. 2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin. Chem., 28, 1379-1388.
75. Welch, G.N. and Loscalzo, J. (1998) Homocysteine and atherothrombosis. N. Engl. J. Med., 338, 1042-1050.