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Volumn 131, Issue 5, 1999, Pages 363-375

Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE;

EID: 0033533527     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-131-5-199909070-00008     Document Type: Review
Times cited : (821)

References (95)
  • 1
    • 0344198241 scopus 로고    scopus 로고
    • Laboratory Centre for Disease Control, Statistics Canada, Accessed 22 March
    • Heart disease and stroke in Canada. 2. Deaths from cardiovascular disease, Laboratory Centre for Disease Control, Statistics Canada, 1997. http://www .hsf.ca/stats/stats-facts.htm. Accessed 22 March 1999.
    • (1997) Heart Disease and Stroke in Canada. 2. Deaths from Cardiovascular Disease
  • 2
    • 0021741438 scopus 로고
    • The decline in ischemic heart disease mortality rates. An analysis of the comparative effects of medical interventions and changes in lifestyle
    • Goldman L, Cook EF. The decline in ischemic heart disease mortality rates. An analysis of the comparative effects of medical interventions and changes in lifestyle. Ann Intern Med. 1984;101:825-36.
    • (1984) Ann Intern Med. , vol.101 , pp. 825-836
    • Goldman, L.1    Cook, E.F.2
  • 4
    • 0029060065 scopus 로고
    • Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five year follow-up of the seven countries study
    • Verschuren WM, Jacobs DR, Bloemberg BP, Kromhout D, Menotti A, Aravanis C et al. Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five year follow-up of the seven countries study. JAMA. 1995;274:131-6.
    • (1995) JAMA , vol.274 , pp. 131-136
    • Verschuren, W.M.1    Jacobs, D.R.2    Bloemberg, B.P.3    Kromhout, D.4    Menotti, A.5    Aravanis, C.6
  • 5
    • 0018412417 scopus 로고
    • Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study
    • Kannel WB, Castelli WP. Gordon T, Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study. Ann Intern Med. 1979;90:85-91.
    • (1979) Ann Intern Med. , vol.90 , pp. 85-91
    • Kannel, W.B.1    Castelli, W.P.2    Gordon, T.3
  • 6
    • 0025663461 scopus 로고
    • Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. A preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group
    • Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. A preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. JAMA. 1990;264:3018-24.
    • (1990) JAMA , vol.264 , pp. 3018-3024
  • 7
    • 16944362822 scopus 로고    scopus 로고
    • Effects of serum lipoproteins and smoking on atherosclerosis in young men and women
    • The PDAY Research Group Pathobiological Determinants of Atherosclerosis in Youth
    • McGill HC Jr, McMahan CA, Malcom GT, Oalmann MC, Strong JP. Effects of serum lipoproteins and smoking on atherosclerosis in young men and women. The PDAY Research Group Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol. 1997;17:95-106.
    • (1997) Arterioscler Thromb Vasc Biol. , vol.17 , pp. 95-106
    • McGill H.C., Jr.1    McMahan, C.A.2    Malcom, G.T.3    Oalmann, M.C.4    Strong, J.P.5
  • 8
    • 0023025526 scopus 로고
    • Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)
    • Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA. 1986;256:2823-8.
    • (1986) JAMA , vol.256 , pp. 2823-2828
    • Stamler, J.1    Wentworth, D.2    Neaton, J.D.3
  • 11
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995;274:1049-57.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 12
    • 0031748093 scopus 로고    scopus 로고
    • The metabolism of homocysteine: Pathways and regulation
    • Finkelstein JD. The metabolism of homocysteine: pathways and regulation. Eur J Pediatr. 1998;157(Suppl 2):S40-4.
    • (1998) Eur J Pediatr. , vol.157 , Issue.SUPPL. 2
    • Finkelstein, J.D.1
  • 13
    • 0029257541 scopus 로고
    • Homocysteine species as components of plasma redox thiol status
    • Ueland PM. Homocysteine species as components of plasma redox thiol status [Editorial]. Clin Chem. 1995;41:340-2.
    • (1995) Clin Chem. , vol.41 , pp. 340-342
    • Ueland, P.M.1
  • 14
    • 0031778475 scopus 로고    scopus 로고
    • Biochemistry and molecular genetics of cystathionine beta-synthase deficiency
    • Kraus JP. Biochemistry and molecular genetics of cystathionine beta-synthase deficiency. Eur J Pediatr. 1998;157(Suppl 2):S50-3.
    • (1998) Eur J Pediatr. , vol.157 , Issue.SUPPL. 2
    • Kraus, J.P.1
  • 16
    • 0016743933 scopus 로고
    • Homocysteine theory of arteriosclerosis
    • McCully KS, Wilson RB. Homocysteine theory of arteriosclerosis. Atherosclerosis. 1975;22:215-27.
    • (1975) Atherosclerosis , vol.22 , pp. 215-227
    • McCully, K.S.1    Wilson, R.B.2
  • 17
    • 0031886747 scopus 로고    scopus 로고
    • Enzyme conversion immunoassay for determining total homocysteine in plasma or serum
    • Frantzen F, Faaren AL, Alfheim I, Nordhei AK. Enzyme conversion immunoassay for determining total homocysteine in plasma or serum. Clin Chem. 1998;44:311-6.
    • (1998) Clin Chem. , vol.44 , pp. 311-316
    • Frantzen, F.1    Faaren, A.L.2    Alfheim, I.3    Nordhei, A.K.4
  • 18
    • 0029019141 scopus 로고
    • Post-methionine load hyperhomocysteinemia in persons with normal fasting total homocysteine: Initial results from the NHLBI Family Heart Study
    • Bostom AG, Jacques PF, Nadeau MR, Williams RR, Ellison RC, Selhub J. Post-methionine load hyperhomocysteinemia in persons with normal fasting total homocysteine: initial results from the NHLBI Family Heart Study. Atherosclerosis. 1995;116:147-51.
    • (1995) Atherosclerosis , vol.116 , pp. 147-151
    • Bostom, A.G.1    Jacques, P.F.2    Nadeau, M.R.3    Williams, R.R.4    Ellison, R.C.5    Selhub, J.6
  • 19
    • 1842331509 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for vascular disease
    • The European Concerted Action Project
    • Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA. 1997;277:1775-81.
    • (1997) JAMA , vol.277 , pp. 1775-1781
    • Graham, I.M.1    Daly, L.E.2    Refsum, H.M.3    Robinson, K.4    Brattstrom, L.E.5    Ueland, P.M.6
  • 20
    • 0026505842 scopus 로고
    • The effect of blood sample aging and food consumption on plasma total homocysteine levels
    • Ubbink JB, Vermaak WJ, van der Merwe A, Becker PJ. The effect of blood sample aging and food consumption on plasma total homocysteine levels. Clin Chim Acta. 1992;207:119-28.
    • (1992) Clin Chim Acta , vol.207 , pp. 119-128
    • Ubbink, J.B.1    Vermaak, W.J.2    Van Der Merwe, A.3    Becker, P.J.4
  • 21
    • 0028073595 scopus 로고
    • Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects
    • Guttormsen AB, Schneede J, Fiskerstrand T, Ueland PM, Refsum HM. Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects. J Nutr. 1994;124:1934-41.
    • (1994) J Nutr. , vol.124 , pp. 1934-1941
    • Guttormsen, A.B.1    Schneede, J.2    Fiskerstrand, T.3    Ueland, P.M.4    Refsum, H.M.5
  • 22
  • 23
    • 0029939676 scopus 로고    scopus 로고
    • Homocysteine and vascular disease
    • McCully KS. Homocysteine and vascular disease. Nat Med. 1996;2:386-9.
    • (1996) Nat Med. , vol.2 , pp. 386-389
    • McCully, K.S.1
  • 24
    • 0032499126 scopus 로고    scopus 로고
    • Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease
    • Malinow MR, Duell PB, Hess DL, Andersen PH, Kruger WD, Phillipson BE, et al. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. N Engl J Med. 1998;338:1009-15.
    • (1998) N Engl J Med. , vol.338 , pp. 1009-1015
    • Malinow, M.R.1    Duell, P.B.2    Hess, D.L.3    Andersen, P.H.4    Kruger, W.D.5    Phillipson, B.E.6
  • 26
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270:2693-8.
    • (1993) JAMA , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.3    Rush, D.4    Rosenberg, I.H.5
  • 27
    • 0027392610 scopus 로고
    • Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia
    • Ubbink JB, Vermaak WJ, van der Merwe A, Becker PJ. Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr. 1993;57:47-53.
    • (1993) Am J Clin Nutr. , vol.57 , pp. 47-53
    • Ubbink, J.B.1    Vermaak, W.J.2    Van Der Merwe, A.3    Becker, P.J.4
  • 29
    • 0024431701 scopus 로고
    • Folate intake and food sources in the US population
    • Subar AF, Block G, James LD. Folate intake and food sources in the US population. Am J Clin Nutr. 1989;50:508-16.
    • (1989) Am J Clin Nutr. , vol.50 , pp. 508-516
    • Subar, A.F.1    Block, G.2    James, L.D.3
  • 32
    • 0017197285 scopus 로고
    • Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis
    • Harker LA, Ross R, Slichter SJ, Scott CR. Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis. J Clin Invest. 1976;58:731-41.
    • (1976) J Clin Invest. , vol.58 , pp. 731-741
    • Harker, L.A.1    Ross, R.2    Slichter, S.J.3    Scott, C.R.4
  • 33
    • 0018858624 scopus 로고
    • Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury
    • Wall RT, Harlan JM, Harker LA, Striker GE. Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res. 1980;18:113-21.
    • (1980) Thromb Res. , vol.18 , pp. 113-121
    • Wall, R.T.1    Harlan, J.M.2    Harker, L.A.3    Striker, G.E.4
  • 34
    • 0022552919 scopus 로고
    • Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine
    • Starkebaum G, Harlan JM. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest. 1985;77: 1370-6.
    • (1985) J Clin Invest. , vol.77 , pp. 1370-1376
    • Starkebaum, G.1    Harlan, J.M.2
  • 35
    • 0342624737 scopus 로고    scopus 로고
    • Homocysteine mediated endothelial cell toxicity and its amelioration
    • Blundell G, Jones BG, Rose FA, Tudball N. Homocysteine mediated endothelial cell toxicity and its amelioration. Atherosclerosis. 1996;122:163-72.
    • (1996) Atherosclerosis , vol.122 , pp. 163-172
    • Blundell, G.1    Jones, B.G.2    Rose, F.A.3    Tudball, N.4
  • 36
    • 0027531427 scopus 로고
    • Adverse vascular effects of homocysteine are modulated by endotheliumderived relaxing factor and related oxides of nitrogen
    • Stamler JS, Osborne JA. Jaraki O, Rabbani LE, Mullins M, Sirtgel D, et al. Adverse vascular effects of homocysteine are modulated by endotheliumderived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993;91: 308-18.
    • (1993) J Clin Invest. , vol.91 , pp. 308-318
    • Stamler, J.S.1    Osborne, J.A.2    Jaraki, O.3    Rabbani, L.E.4    Mullins, M.5    Sirtgel, D.6
  • 38
    • 0027255291 scopus 로고
    • Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents
    • Celermajer DS, Sorensen K, Ryalls M, Robinson J, Thomas O. Leonard JV, et al. Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents. J Am Coll Cardiol. 1993;22:854-8.
    • (1993) J Am Coll Cardiol. , vol.22 , pp. 854-858
    • Celermajer, D.S.1    Sorensen, K.2    Ryalls, M.3    Robinson, J.4    Thomas, O.5    Leonard, J.V.6
  • 39
    • 0031018333 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans
    • Tawakol A, Omland T, Gerhard M, Wu JT, Creager MA. Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation. 1997;95:1119-21.
    • (1997) Circulation , vol.95 , pp. 1119-1121
    • Tawakol, A.1    Omland, T.2    Gerhard, M.3    Wu, J.T.4    Creager, M.A.5
  • 41
  • 42
    • 0029154073 scopus 로고
    • Oral administration of homocysteine leads to increased plasma triglycerides and homocysteic acid - Additional mechanisms in homocysteine induced endothelial damage?
    • Frauscher G, Karnaukhova E, Muehl A, Hoeger H, Lubec B. Oral administration of homocysteine leads to increased plasma triglycerides and homocysteic acid - additional mechanisms in homocysteine induced endothelial damage? Life Sci. 1995;57:813-7.
    • (1995) Life Sci. , vol.57 , pp. 813-817
    • Frauscher, G.1    Karnaukhova, E.2    Muehl, A.3    Hoeger, H.4    Lubec, B.5
  • 43
    • 0029891753 scopus 로고    scopus 로고
    • Effect of homocysteine on copper ion-catalyzed, azo compound-initiated, and mononuclear cell-mediated oxidative modification of low density lipoprotein
    • Halvorsen B, Brude I, Drevon CA, Nysom J, Ose L, Christiansen EN, et al. Effect of homocysteine on copper ion-catalyzed, azo compound-initiated, and mononuclear cell-mediated oxidative modification of low density lipoprotein. J Lipid Res. 1996;37:1591-600.
    • (1996) J Lipid Res. , vol.37 , pp. 1591-1600
    • Halvorsen, B.1    Brude, I.2    Drevon, C.A.3    Nysom, J.4    Ose, L.5    Christiansen, E.N.6
  • 45
    • 0022472013 scopus 로고
    • Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator
    • Rodgers GM, Kane WH. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest. 1986:77:1909-16.
    • (1986) J Clin Invest. , vol.77 , pp. 1909-1916
    • Rodgers, G.M.1    Kane, W.H.2
  • 46
    • 0025190042 scopus 로고
    • Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells
    • Rodgers GM, Conn MT. Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood. 1990;75: 895-901.
    • (1990) Blood , vol.75 , pp. 895-901
    • Rodgers, G.M.1    Conn, M.T.2
  • 47
    • 0026345948 scopus 로고
    • Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine
    • Lentz SR, Sadler JE. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest. 1991;88:1906-14.
    • (1991) J Clin Invest. , vol.88 , pp. 1906-1914
    • Lentz, S.R.1    Sadler, J.E.2
  • 48
    • 0026773724 scopus 로고
    • An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells
    • Hayashi T, Honda G, Suzuki K. An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells. Blood. 1992;79:2930-6.
    • (1992) Blood , vol.79 , pp. 2930-2936
    • Hayashi, T.1    Honda, G.2    Suzuki, K.3
  • 49
    • 0027319970 scopus 로고
    • Homocysteine, a thrombogenic agent, suppresses anticoagulant heparin sulfate expression in cultured porcine aortic endothelial cells
    • Nishinaga M, Ozawa T, Shimada K. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparin sulfate expression in cultured porcine aortic endothelial cells. J Clin Invest. 1993;92:1381-6.
    • (1993) J Clin Invest. , vol.92 , pp. 1381-1386
    • Nishinaga, M.1    Ozawa, T.2    Shimada, K.3
  • 50
    • 0027288252 scopus 로고
    • Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor
    • Hajjar KA. Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J Clin Invest. 1993;91: 2873-9.
    • (1993) J Clin Invest. , vol.91 , pp. 2873-2879
    • Hajjar, K.A.1
  • 51
    • 0032499024 scopus 로고    scopus 로고
    • Homocysteine and atherothrombosis
    • Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998;338:1042-50.
    • (1998) N Engl J Med. , vol.338 , pp. 1042-1050
    • Welch, G.N.1    Loscalzo, J.2
  • 52
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase [Letter], Nat Genet. 1995;10:111-3.
    • (1995) Nat Genet. , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 53
    • 0030610090 scopus 로고    scopus 로고
    • The mutation Ala677→Val in the methylene tetrahydrofolate reductase gene: A risk factor for arterial disease and venous thrombosis
    • Arruda VR, von Zuben PM, Chiaparini LC, Annichino-Bizzacchi JM, Costa FF. The mutation Ala677→Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. Thromb Haemost. 1997;77:818-21.
    • (1997) Thromb Haemost. , vol.77 , pp. 818-821
    • Arruda, V.R.1    Von Zuben, P.M.2    Chiaparini, L.C.3    Annichino-Bizzacchi, J.M.4    Costa, F.F.5
  • 54
    • 0029974036 scopus 로고    scopus 로고
    • Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter)
    • The Hordaland Homocysteine Study
    • Guttormsen AB, Ueland PM, Nesthus I, Nygard O, Schneede J, Vollset SE, et al. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study. J Clin Invest. 1996;98:2174-83.
    • (1996) J Clin Invest. , vol.98 , pp. 2174-2183
    • Guttormsen, A.B.1    Ueland, P.M.2    Nesthus, I.3    Nygard, O.4    Schneede, J.5    Vollset, S.E.6
  • 55
    • 0032497941 scopus 로고    scopus 로고
    • Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: The result of a meta-analysis
    • Brattstrom L, Wilcken DE, Ohrvik J, Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation. 1998;98: 2520-5.
    • (1998) Circulation , vol.98 , pp. 2520-2525
    • Brattstrom, L.1    Wilcken, D.E.2    Ohrvik, J.3    Brudin, L.4
  • 56
    • 0027523674 scopus 로고
    • Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults
    • The Atherosclerosis Risk in Communities Study
    • Malinow MR, Nieto FJ, Szklo M, Chambless LE, Bond G. Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study. Circulation. 1993;87: 1107-13.
    • (1993) Circulation , vol.87 , pp. 1107-1113
    • Malinow, M.R.1    Nieto, F.J.2    Szklo, M.3    Chambless, L.E.4    Bond, G.5
  • 57
    • 0030956453 scopus 로고    scopus 로고
    • Association between plasma homocysteine and extracranial carotid arterial disease in older persons
    • Aronow WS, Ahn C, Schoenfeld MR. Association between plasma homocysteine and extracranial carotid arterial disease in older persons. Am J Cardiol. 1997;79:1432-33.
    • (1997) Am J Cardiol. , vol.79 , pp. 1432-1433
    • Aronow, W.S.1    Ahn, C.2    Schoenfeld, M.R.3
  • 58
    • 0029791893 scopus 로고    scopus 로고
    • Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolernia and control subjects
    • Tonstad S, Joakimsen O, Stensland-Bugge E, Leren TP, Ose L, Russell D, et al. Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolernia and control subjects. Arterioscler Thromb Vasc Biol. 1996;16:984-91.
    • (1996) Arterioscler Thromb Vasc Biol. , vol.16 , pp. 984-991
    • Tonstad, S.1    Joakimsen, O.2    Stensland-Bugge, E.3    Leren, T.P.4    Ose, L.5    Russell, D.6
  • 63
    • 0030053145 scopus 로고    scopus 로고
    • Plasma homocysteine and severity of atherosclerosis in young patients with lowerlimb atherosclerotic disease
    • van den Berg M, Stehouwer CD, Bierdrager E, Rauwerda JA. Plasma homocysteine and severity of atherosclerosis in young patients with lowerlimb atherosclerotic disease. Arterioscler Thromb Vasc Biol. 1996;16:165-71.
    • (1996) Arterioscler Thromb Vasc Biol. , vol.16 , pp. 165-171
    • Van Den Berg, M.1    Stehouwer, C.D.2    Bierdrager, E.3    Rauwerda, J.A.4
  • 65
    • 0030880665 scopus 로고    scopus 로고
    • A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease
    • Markus HS, Ali N, Swaminathan R, Sankaralingam A, Molloy J, Powell J. A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease. Stroke. 1997;28:1739-43.
    • (1997) Stroke , vol.28 , pp. 1739-1743
    • Markus, H.S.1    Ali, N.2    Swaminathan, R.3    Sankaralingam, A.4    Molloy, J.5    Powell, J.6
  • 67
    • 0029088620 scopus 로고
    • Higher plasma homocyst(e)ine and increased susceptibility to adverse effects of low folate in early familial coronary artery disease
    • Hopkins PN, Wu LL, Wu J, Hunt SC, James BC, Vincent GM, et al. Higher plasma homocyst(e)ine and increased susceptibility to adverse effects of low folate in early familial coronary artery disease. Arterioscler Thromb Vasc Biol. 1995;15:1314-20.
    • (1995) Arterioscler Thromb Vasc Biol. , vol.15 , pp. 1314-1320
    • Hopkins, P.N.1    Wu, L.L.2    Wu, J.3    Hunt, S.C.4    James, B.C.5    Vincent, G.M.6
  • 69
    • 0028855901 scopus 로고
    • Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease
    • Robinson K, Mayer EL, Miller DP, Green R, van Lente F, Gupta A, et al. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation. 1995; 92:2825-30.
    • (1995) Circulation , vol.92 , pp. 2825-2830
    • Robinson, K.1    Mayer, E.L.2    Miller, D.P.3    Green, R.4    Van Lente, F.5    Gupta, A.6
  • 70
    • 0030603998 scopus 로고    scopus 로고
    • Plasma homocyst(e)ine levels and graded risk for myocardial infarction: Findings in two populations at contrasting risk for coronary heart disease
    • Malinow MR, Ducimetiere P, Luc G, Evans AE, Arveiler D, Cambien F. et at. Plasma homocyst(e)ine levels and graded risk for myocardial infarction: findings in two populations at contrasting risk for coronary heart disease. Atherosclerosis. 1996;126:27-34.
    • (1996) Atherosclerosis , vol.126 , pp. 27-34
    • Malinow, M.R.1    Ducimetiere, P.2    Luc, G.3    Evans, A.E.4    Arveiler, D.5    Cambien, F.6
  • 71
    • 0342437489 scopus 로고    scopus 로고
    • Plasma homocysteine and cardiovascular disease mortality
    • Alfthan G, Aro A, Gey KF. Plasma homocysteine and cardiovascular disease mortality [Letter]. Lancet. 1997;349:397.
    • (1997) Lancet , vol.349 , pp. 397
    • Alfthan, G.1    Aro, A.2    Gey, K.F.3
  • 72
    • 0026684554 scopus 로고
    • A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians
    • Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullmann D, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA. 1992;268:877-81.
    • (1992) JAMA , vol.268 , pp. 877-881
    • Stampfer, M.J.1    Malinow, M.R.2    Willett, W.C.3    Newcomer, L.M.4    Upson, B.5    Ullmann, D.6
  • 73
    • 0032571596 scopus 로고    scopus 로고
    • Homocysteine and ischemic heart disease: Results of a prospective study with implications regarding prevention
    • Wald NJ, Watt HC, Law MR, Weir DG, McPartlin J, Scott JM. Homocysteine and ischemic heart disease: results of a prospective study with implications regarding prevention. Arch Intern Med. 1998;158:862-7.
    • (1998) Arch Intern Med. , vol.158 , pp. 862-867
    • Wald, N.J.1    Watt, H.C.2    Law, M.R.3    Weir, D.G.4    McPartlin, J.5    Scott, J.M.6
  • 74
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
    • Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet. 1995;346:1395-8.
    • (1995) Lancet , vol.346 , pp. 1395-1398
    • Perry, I.J.1    Refsum, H.2    Morris, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.G.6
  • 77
    • 0030603334 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus
    • Petri M, Roubenoff R, Dallal GE, Nadeau MR, Selhub J, Rosenberg IH. Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus. Lancet. 1996;348:1120-4.
    • (1996) Lancet , vol.348 , pp. 1120-1124
    • Petri, M.1    Roubenoff, R.2    Dallal, G.E.3    Nadeau, M.R.4    Selhub, J.5    Rosenberg, I.H.6
  • 78
    • 0033545179 scopus 로고    scopus 로고
    • Homocysteine and short-term risk of myocardial infarction and stroke in the elderly: The Rotterdam study
    • Bots ML, Launer LJ, Lindemans J, Hoes AW, Hofman A, Witteman JC, et al. Homocysteine and short-term risk of myocardial infarction and stroke in the elderly: the Rotterdam study. Arch Intern Med. 1999;159:38-44.
    • (1999) Arch Intern Med. , vol.159 , pp. 38-44
    • Bots, M.L.1    Launer, L.J.2    Lindemans, J.3    Hoes, A.W.4    Hofman, A.5    Witteman, J.C.6
  • 82
    • 0028219672 scopus 로고
    • Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study
    • Alfthan G, Pekkanen J, Jauhiainen M, Pitkaniemi J, Karvonen M, Tuomilehto J, et al. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis. 1994;106:9-19.
    • (1994) Atherosclerosis , vol.106 , pp. 9-19
    • Alfthan, G.1    Pekkanen, J.2    Jauhiainen, M.3    Pitkaniemi, J.4    Karvonen, M.5    Tuomilehto, J.6
  • 84
    • 0032555167 scopus 로고    scopus 로고
    • Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: The Atherosclerosis Risk in Communities (ARIC) study
    • Folsom AR, Nieto FJ, McGovern PG, Tsai MY, Malinow MR, Eckfeldt JH, et al. Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 1998;98: 204-10
    • (1998) Circulation , vol.98 , pp. 204-210
    • Folsom, A.R.1    Nieto, F.J.2    McGovern, P.G.3    Tsai, M.Y.4    Malinow, M.R.5    Eckfeldt, J.H.6
  • 85
    • 0029938206 scopus 로고    scopus 로고
    • Serum folate and risk of fatal coronary heart disease
    • Morrison HI, Schaubel D, Desmeules M, Wigle DT. Serum folate and risk of fatal coronary heart disease. JAMA. 1996;275:1893-6.
    • (1996) JAMA , vol.275 , pp. 1893-1896
    • Morrison, H.I.1    Schaubel, D.2    Desmeules, M.3    Wigle, D.T.4
  • 86
    • 0029012077 scopus 로고
    • Serum folate and risk for ischemic stroke. First National Health and Nutrition Examination Survey epidemiologic follow-up study
    • Giles WH, Kittner SJ, Anda RF, Croft JB, Casper ML. Serum folate and risk for ischemic stroke. First National Health and Nutrition Examination Survey epidemiologic follow-up study. Stroke. 1995;26:1166-70.
    • (1995) Stroke , vol.26 , pp. 1166-1170
    • Giles, W.H.1    Kittner, S.J.2    Anda, R.F.3    Croft, J.B.4    Casper, M.L.5
  • 88
    • 0032501963 scopus 로고    scopus 로고
    • Low circulating folate and vitamin B6 concentrations: Risk factors for stroke, peripheral vascular disease, and coronary artery disease
    • European COMAC Group
    • Robinson K, Arheart K, Refsum H, Brattstrom L, Boers G, Ueland P, et al. Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group. Circulation. 1998;97:437-43.
    • (1998) Circulation , vol.97 , pp. 437-443
    • Robinson, K.1    Arheart, K.2    Refsum, H.3    Brattstrom, L.4    Boers, G.5    Ueland, P.6
  • 91
    • 17344370074 scopus 로고    scopus 로고
    • Vitamin supplementation reduces blood homocysteine levels: A controlled trial in patients with venous thrombosis and healthy volunteers
    • den Heijer M, Brouwer IA, Bos GM, Blom HJ, van der Put NM, Spaans AP, et al. Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients with venous thrombosis and healthy volunteers. Arterioscler Thromb Vasc Biol. 1998;18:356-61.
    • (1998) Arterioscler Thromb Vasc Biol. , vol.18 , pp. 356-361
    • Den Heijer, M.1    Brouwer, I.A.2    Bos, G.M.3    Blom, H.J.4    Van Der Put, N.M.5    Spaans, A.P.6
  • 92
    • 2242477014 scopus 로고    scopus 로고
    • Lowering blood homocysteine with folic acid based supplements: Meta-analysisof randomised trials
    • Homocysteine Lowering Trialists' Collaboration
    • Lowering blood homocysteine with folic acid based supplements: meta-analysisof randomised trials. Homocysteine Lowering Trialists' Collaboration BMJ. 1998;316:894-8.
    • (1998) BMJ , vol.316 , pp. 894-898
  • 93
    • 0032430436 scopus 로고    scopus 로고
    • Can dietary supplements with folic acid or vitamin B6 reduce cardiovascular risk? Design of clinical trials to test the homocysteine hypothesis of vascular disease
    • Clarke R, Collins R. Can dietary supplements with folic acid or vitamin B6 reduce cardiovascular risk? Design of clinical trials to test the homocysteine hypothesis of vascular disease. J Cardiovasc Risk. 1998;5:249-55.
    • (1998) J Cardiovasc Risk , vol.5 , pp. 249-255
    • Clarke, R.1    Collins, R.2
  • 95
    • 0345492092 scopus 로고    scopus 로고
    • Stroke Unit, Royal Perth Hospital, University of Western Australia, Australia
    • VITATOPS Study Group. Vitamins to Prevent Stroke (VITATOPS) Study. Stroke Unit, Royal Perth Hospital, University of Western Australia, Australia.
    • Vitamins to Prevent Stroke (VITATOPS) Study


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