Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division

Blood

Volumn 99, Issue 7, 2002, Pages 2397-2407

  Kearney, Joseph B ^a   Ambler, Carrie A ^a   Monaco, Kelli Ann ^c   Johnson, Natalie ^c   Rapoport, Rebecca G ^c   Bautch, Victoria L ^a,b,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CADHERIN; CELL ADHESION MOLECULE; MITOMYCIN C; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIVISION; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; MITOSIS INDEX; MODEL; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; STEM CELL; VASCULARIZATION;

ANIMALS; BETA-GALACTOSIDASE; CELL DIVISION; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX PROTEINS; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; MITOMYCIN; MITOTIC INDEX; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; STEM CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 0036530222     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.7.2397     Document Type: Article

References (72)

1. Blood vessel formation: What is its molecular basis?
2. What guides early embryonic blood vessel formation?
3. Molecular mechanisms of blood vessel growth
4. Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells
5. Matrix-driven cell size change modulates aortic endothelial cell proliferation and sheet migration
6. Human vascular endothelial cell attachment and growth inhibition by type V collagen
7. Cytoskeletal changes induced by excess extracellular matrix impair endothelial cell replication
8. Inhibition of endothelial cell adhesion and proliferation by extracellular matrix from vascular smooth muscle cells: Role of type V collagen
9. The biology of vascular endothelial growth factor
10. Vascular endothelial growth factor (VEGF) and its receptors
11. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
12. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
13. Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A
14. Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression
15. Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization
16. VEGF gene delivery to myocardium: Deleterious effects of unregulated expression
17. Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor
18. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
19. Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues
20. Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
21. Multiple developmental roles of VEGF suggested by a LacZ-tagged allele
22. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family
23. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
24. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
25. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium
26. Structure and dual function of vascular endothelial growth factor receptor-1 (Flt-1)
27. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
28. A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis
29. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
30. Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent
31. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells
32. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants
33. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
34. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
35. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
36. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract
37. Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells
38. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
39. Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR
40. Role of VEGF receptor-1 (Flt-1) in mediating calcium-dependent nitric oxide release and limiting DNA synthesis in human trophoblast cells
41. Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells
42. Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 down-modulates VPFNEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways
43. Blood island formation in attached cultures of murine embryonic stem cells
44. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
45. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
46. Histochemical tests for protein and amino acids: The characterization of basic proteins
47. Vasculogenesis and angiogenesis in embryonic-stemcell-derived embryoid bodies
48. Embryonic stem cell-derived cystic embryoid bodies form vascular channels: An in vitro model of blood vessel development
49. Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps
50. Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture
51. A common precursor for hematopoietic and endothelial cells
52. PE-CAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily
53. Characterization of murine intercellular adhesion molecule-2
54. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
55. Microscopic observations on the growth of blood capillaries in the living mammal
56. Colocalisation of vascular endothelial growth factor and its Flt-1 receptor in human placenta
57. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
58. Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocytemacrophages in humans
59. To differentiate or not to differentiate?
60. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
61. Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide
62. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
63. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
64. Endogenous angiogenesis inhibitors: Angiostatin, endostatin, and other proteolytic fragments
65. Expression of vascular permeability factor (VPFNEGF) messenger RNA by plasma cells: Possible involvement in the development of edema in chronic inflammation
66. Vascular permeability factor/vascular endothelial growth factor: An important mediator of angiogenesis in malignancy and inflammation
67. Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain
68. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
69. Up-regulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PIGF) associated with malignancy in human thyroid tumors and cell lines
70. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model
71. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb