Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 280, Issue 6 24-6, 2001, Pages

  Grishko, Valentina ^a   Solomon, Marie ^a   Wilson, Glenn L ^b   LeDoux, Susan P ^b   Gillespie, Mark N ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

Cytotoxicity; Mitochondrial dexoyribonucleic acid; Oxidant sensitivity

Indexed keywords

FREE RADICAL; HYDROXYL RADICAL; MENADIONE; MITOCHONDRIAL DNA; XANTHINE OXIDASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DOSE RESPONSE; ENDOTHELIUM CELL; GENE SEQUENCE; LUNG ENDOTHELIUM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SEQUENCE ANALYSIS;

EID: 0034983837     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.280.6.l1300     Document Type: Article

References (36)

1. Extra-alveolar vessel fluid filtration coefficients in excised and in situ canine lobes
2. Complementation and segregation behavior of disease-causing mtDNA mutations in cellular model systems
3. Hydrogen peroxide- and peroxynitrite -induced mtDNA damage and dysfunction in vascular endothelial and smooth muscle cells
4. Repair of mtDNA in vertebrates
5. DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall
6. Oxidant stress and adult respiratory distress syndrome
7. Oxygen radicals - An important mediator of sepsis and septic shock
8. Cells depleted of mtDNA (rho0) yield insight into physiological mechanisms
9. 2+ entry
10. The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria
11. Detection of a specific mtDNA deletion in tissues of older humans
12. Enhanced mtDNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to mitochondria
13. Defective repair of oxidative damage in the mtDNA of a xeroderma pigmentosum group A cell line
14. Repair of oxidative damage within the mtDNA of RINr 38 cells
15. Defective repair of oxidative damage in mtDNA in Down's syndrome
16. One- and two-electron reduction of menadione in guinea-pig and rat cardiac tissue
17. Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea
18. 2+-mediated Fenton reactions has possible biological implications
19. Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide
20. Glial cell type-specific responses to menadione-induced oxidative stress
21. Binding of xanthine oxidase to vascular endothelium. Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling
22. DNA damage and oxygen radical toxicity
23. Oxygen free radicals and lungs
24. 2+ and permeability
25. Segmental microvascular permeability in ischemia-reperfusion injury in rat lung
26. Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation
27. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
28. Accumulation of mtDNA defects and changes in mtDNA content in mouse and rat tissues with aging
29. A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene
30. Mitochondria in the etiology and pathogenesis of Parkinson's disease
31. Xanthine oxidase-induced mtDNA damage in pulmonary vascular endothelial cells: Role of elevated intracellular xanthine oxidase activity
32. Mitochondrial diseases in man and mouse
33. Mitochondrial defects in cardiomyopathy and neuromuscular disease
34. The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of alpha 1-antiproteinase against inactivation by hypochlorous acid
35. Canaries in the coal mine: mtDNA and vascular injury from reactive oxygen species
36. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress