Hypoxia, anoxia, and O2 sensing: The search continues

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 283, Issue 5 27-5, 2002, Pages

  Schumacker, Paul T ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; OXYGEN; VASCULOTROPIN;

ANOXIA; CELL SURVIVAL; EDITORIAL; ERYTHROPOIESIS; HOMEOSTASIS; HYPOXIA; LUNG VENTILATION; OXYGEN TENSION; OXYGEN TRANSPORT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; GENETIC PROCEDURES; HUMAN; NOTE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANOXIA; BIOSENSING TECHNIQUES; HUMANS; OXYGEN;

EID: 0036838355     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00205.2002     Document Type: Editorial

References (26)

1. Agani FH, Pichiule P, Chavez JC, and LaManna JC. The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J Biol Chem 275: 35863-35867, 2000.
2. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, and Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95: 11715-11720, 1998.
3. 2 sensing. J Biol Chem 275: 25130-25138, 2000.
4. 0) yield insight into physiological mechanisms. FEBS Lett 454: 173-176, 1999.
5. Clifford SC, Cockman ME, Smallwood AC, Mole DR, Woodward ER, Maxwell PH, Ratcliffe PJ, and Maher ER. Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. Hum Mol Genet 10: 1029-1038, 2001.
6. Gleadle JM, Ebert BL, and Ratcliffe PJ. Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Eur J Biochem 234: 92-99, 1995.
7. Grishko V, Solomon M, Breit JF, Killilea DW, LeDoux SP, Wilson GL, and Gillespie MN. Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene. FASEB J 15: 1267-1269, 2001.
8. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95: 7987-7992, 1998.
9. 2 sensing. Science 292: 464-468, 2001.
10. 2-regulated prolyl hydroxylation. Science 292: 468-472, 2001.
11. Kline DD, Peng YJ, Manalo DJ, Semenza GL, and Prabhakar NR. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. Proc Natl Acad Sci USA 99: 821-826, 2002.
12. Kotch LE, Iyer NV, Laughner E, and Semenza GL. Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 209: 254-267, 1999.
13. Kourembanas S, Morita T, Christou H, Liu Y, Koike H, Brodsky D, Arthur V, and Mitsial SA. Hypoxic responses of vascular cells. Chest 114: 25S-28S, 1998.
14. Lando D, Peet DJ, Whelan DA, Gorman JJ, and Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch. Science 295: 858-861, 2002.
15. Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, and Simon MC. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386: 403-407, 1997.
16. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, and Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275, 1999.
17. a.Salceda S and Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272: 22642-22647, 1997.
18. b.Schroedl C, McClintock DS, Budinger GRS, and Chandel NS. Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 283: L922-L931, 2002.
19. Semenza GL. HIF-1: Mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
20. 2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus. Cell 107: 1-3, 2001.
21. Semenza GL, Nejfelt MK, Chi SM, and Antonarakis SE. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc Natl Acad Sci USA 88: 5680-5684, 1991.
22. Semenza GL and Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12: 5447-5454, 1992.
23. Shimoda LA, Manalo DJ, Sham JSK, Semenza GL, and Sylvester JT. Partial HIF-1α deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am J Physiol Lung Cell Mol Physiol 281: L202-L208, 2001.
24. Srinivas V, Leshchinsky I, Sang N, King MP, Minchenko A, and Caro J. Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J Biol Chem 276: 21995-21998, 2001.
25. Vaux EC, Metzen E, Yeates KM, and Ratcliffe PJ. Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood 98: 296-302, 2001.
26. Wang GL and Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270: 1230-1237, 1995.