GDNF recruits the signaling crew into lipid rafts

Trends in Neurosciences

Volumn 24, Issue 8, 2001, Pages 427-429

  Saarma, Mart ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR FAMILY RECEPTOR ALPHA1; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR FAMILY RECEPTOR ALPHA4; GLYCOSYLPHOSPHATIDYLINOSITOL; LIGAND; MEMBRANE LIPID; NEUROTROPHIN RECEPTOR; PROTEIN RET; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

CENTRAL NERVOUS SYSTEM; ENZYME ACTIVATION; NERVE CELL; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 0035426416     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(00)01864-6     Document Type: Review

References (12)

1. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
2. GDNF family neurotrophic factor signalling: Four masters one servant?
3. The GDNF family ligands and receptors - Implications for neuronal development
4. Released GFRα1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts
5. Lipid sorting in epithelial cells
6. Lipid rafts and signal transduction
7. GDNF triggers a novel Ret-independent Src-kinase family-coupled signaling via a GPI-linked GDNF receptor α1
8. Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells
9. GFRα-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation and neuronal survival
10. c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway
11. Expression and alternative splicing of mouse Gfrα4 suggests roles in endocrine cell development
12. GDNF family ligands and receptors are differentially regulated after brain insults in the rat