A novel type of RET rearrangement (PTC8) in childhood papillary thyroid carcinomas and characterization of the involved gene (RFG8)

Cancer Research

Volumn 60, Issue 24, 2000, Pages 7028-7032

  Klugbauer, Sabine ^a   Jauch, Anna ^b   Lengfelder, Edmund ^a   Demidchik, Evgenij ^c   Rabes, Hartmut M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Thyroid Cancer Center   (Belarus)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GENE PRODUCT; HYBRID PROTEIN; PROTEIN RET; UNCLASSIFIED DRUG;

ARTICLE; CHILDHOOD CANCER; CHROMOSOME 18Q; CHROMOSOME TRANSLOCATION; DNA FLANKING REGION; DNA SEQUENCE; FUSION GENE; GENE ACTIVATION; GENE FREQUENCY; GENE LOCATION; GENE REARRANGEMENT; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID CARCINOMA;

ACCIDENTS, RADIATION; ADOLESCENT; AMINO ACID SEQUENCE; BASE SEQUENCE; BLOTTING, NORTHERN; CARCINOMA, PAPILLARY; CHROMOSOMES, HUMAN, PAIR 18; CYTOPLASM; DNA, COMPLEMENTARY; DROSOPHILA PROTEINS; FEMALE; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MOLECULAR SEQUENCE DATA; POWER PLANTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYROID NEOPLASMS; TISSUE DISTRIBUTION; TRANSLOCATION, GENETIC; UKRAINE;

EID: 0034671411     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Developmental expression of the RET proto oncogene
2. High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident
3. Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident
4. Distinct pattern of RET oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children
5. Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial cells
6. The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas
7. Thyroid-stimulating hormone promotes growth of thyroid carcinomas in transgenic mice with targeted expression of the ret/PTC1 oncogene
8. The RET/PTC3 oncogene: Metastatic solid-type papillary carcinomas in murine thyroids
9. A new form of RET rearrangement in thyroid carcinomas of children after the Chernobyl reactor accident
10. Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-Chernobyl papillary thyroid carcinomas: Biological, phenotypic, and clinical implications
11. Detection of novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5
12. Molecular analysis of new subtypes of ELE/RET rearrangements, their reciprocal transcripts and break-points in papillary thyroid carcinoma of children after Chernobyl
13. Molecular genetics of childhood papillary thyroid carcinomas after irradiation: High prevalence of RET rearrangement
14. Pediatric thyroid cancer after the Chernobyl disaster
15. Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy
16. Chromosome analysis by non-isotopic in situ hybridization
17. Cytogenetic analysis using quantitative, high sensitivity, fluorescence hybridization
18. A new generation of information retrieval tools for biologists: The example of the ExPASy WWW server
19. TIF1γ, a novel member of the transcriptional intermediary factor 1 family
20. Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas
21. Characterization of an inversion on the long arm of chromosome juxtaposes D1OS170 and ret and creating the oncogenic sequence ret/ptc
22. The two genes generating RET/PTC3 are localized in chromosomal banc. 10q1 1.2
23. A simple method for displaying the hydropathic character of a protein
24. Using neural networks for prediction of the subcellular location of proteins
25. Better prediction of protein cellular localization sites with the k nearest neighbors classifier
26. Protein import into the nucleus: An integrated view
27. The PROSITE database, its status in 1999
28. A generalized profile syntax for biomolecular sequences motifs and its function in automatic sequence interpretation
29. Pfam 3.1: 1313 multiple alignments match the majority of proteins
30. Predicting coiled coils by use of pairwise residue correlations
31. Multi Co: I. A program for predicting two- mad and three-stranded coiled coils
32. Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity
33. Topological characteristics of helical repeat proteins
34. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1
35. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells
36. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
37. Cloning and expression of the ret proto-oncogene coding a tyrosine kinase with two potential transmembrane domains