A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities

Cancer Research

Volumn 60, Issue 4, 2000, Pages 873-876

  Li, Long Cheng ^a   Chui, Richard M ^a   Sasaki, Masahiro ^a   Nakajima, Koichi ^a   Perinchery, Geetha ^a   Au, Harry C ^a   Nojima, Dana ^a   Carroll, Peter ^a   Dahiya, Rajvir ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Urology Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UVOMORULIN;

ALLELE; ARTICLE; CANCER RISK; DNA POLYMORPHISM; GENE ACTIVITY; GENE FUNCTION; GENE LOSS; GENETIC MARKER; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

ALLELES; CADHERINS; HUMANS; NUCLEAR PROTEINS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); TRANSCRIPTION, GENETIC;

EID: 0034652622     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science (Washington DC), 251: 1451-1455, 1991.
2. Umbas, R., Schalken, J. A., Aalders, T. W., Carter, B. S., Karthaus, H. F., Schaafsma, H. E., Debruyne, F. M., and Isaacs, W. B. Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res., 52: 5104-5109, 1992.
3. Gamallo, C., Palacios, J., Suarez, A., Pizarro, A., Navarro, P., Quintanilla, M., and Cano, A. Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am. J. Pathol., 142: 987-993, 1993.
4. Pignatelli, M., Ansari, T. W., Gunter, P., Liu, D., Hirano, S., Takeichi, M., Kloppel, G., and Lemoine, N. R. Loss of membranous E-cadherin expression in pancreatic cancer: correlation with lymph node metastasis, high grade, and advanced stage. J. Pathol., 174: 243-248, 1994.
5. Mayer, B., Johnson, J. P., Leitl, F., Jauch, K. W., Heiss, M. M., Schildberg, F. W., Birchmeier, W., and Funke, I. E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res., 53: 1690-1695, 1993.
6. Kinsella, A. R., Lepts, G. C., Hill, C. L., and Jones, M. Reduced E-cadherin expression correlates with increased invasiveness in colorectal carcinoma cell lines. Clin. Exp. Metastasis, 12: 335-342, 1994.
7. Frixen, U. H., Behrens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., Lochner, D., and Birchmeier, W. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol., 113: 173-185, 1991.
8. Efstathiou, J. A., Liu, D., Wheeler, J. M., Kim, H. C., Beck, N. E., Ilyas, M., Karayiannakis, A. J., Mortensen, N. J., Kmiot, W., Playford, R. J., Pignatelli, M., and Bodmer, W. F. Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells. Proc. Natl. Acad. Sci. USA, 96: 2316-2321, 1999.
9. Berx, G., Cleton-Jansen, A. M., Nollet, F., de Leeuw, W. J., van de Vijver, M., Cornelisse, C., and van Roy, F. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J., 14: 6107-6115, 1995.
10. Richards, F. M., McKee, S. A., Rajpar, M. H., Cole, T. R., Evans, D. G., Jankowski, J. A., McKeown, C., Sanders, D. S., and Maher, E. R. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Hum. Mol. Genet., 8: 607-610, 1999.
11. Jankowski, J. A., Bedford, F. K., Boulton, R. A., Cruickshank, N., Hall, C., Elder, J., Allan, R., Forbes, A., Kim, Y. S., Wright, N. A., and Sanders, D. S. Alterations in classical cadherins associated with progression in ulcerative and Crohn's colitis. Lab Investig., 78: 1155-1167, 1998.
12. Geissmann, F., Emile, J. F., Andry, P., Thomas, C., Fraitag, S., De Prost, Y., and Brousse, N. Lack of expression of E-cadherin is associated with dissemination of Langerhans' cell histiocytosis and poor outcome. J. Pathol., 181: 301-304, 1997.
13. Gaetje, R., Kotzian, S., Herrmann, G., Baumann, R., and Starzinski-Powitz, A. Nonmalignant epithelial cells, potentially invasive in human endometriosis, lack the tumor suppressor molecule E-cadherin. Am. J. Pathol., 150: 461-467, 1997.
14. Collins, F. S., Guyer, M. S., and Charkravarti, A. Variations on a theme: cataloging human DNA sequence variation. Science (Washington DC), 278: 1580-1581, 1997.
15. Hagmann, M. Human genome. A good SNP may be hard to find. Science (Washington DC), 285: 21-22, 1999.
16. Bussemakers, M. J., Giroldi, L. A., van Bokhoven, A., and Schalken, J. A. Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter. Biochem. Biophys. Res. Commun., 203: 1284-1290, 1994.
17. Giroldi, L. A., Bringuier, P. P., de Weijert, M., Jansen, C., van Bokhoven, A., and Schalken, J. A. Role of E boxes in the repression of E-cadherin expression. Biochem. Biophys. Res. Commun., 241: 453-458, 1997.