Germline mutations of E-cadherin gene in Korean familial gastric cancer patients

Journal of Human Genetics

Volumn 44, Issue 3, 1999, Pages 177-180

  Yoon, Kyong Ah ^a   Ku, Ja Lok ^a   Yang, Han Kwang ^a   Kim, Woo Ho ^a   Park, Suk Young ^b   Park, Jae Gahb ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Daejeon St Mary's Hospital   (South Korea)

Author keywords

E cadherin; Familial gastric cancer; Germline; Mutation

Indexed keywords

ALANINE; ASPARTIC ACID; DNA; GLYCINE; UVOMORULIN; VALINE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FAMILIAL CANCER; FEMALE; GENE MUTATION; GERM LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PERIPHERAL LYMPHOCYTE; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; SOUTH KOREA; STOMACH CANCER;

EID: 0032920262     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380050137     Document Type: Article

References (9)

1. Becker K-F, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR, Höfler H (1994) E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 54: 3845-3852
2. Berx G, Becker KF, Höfler H, van Roy F (1998) Mutations of the human E-cadherin (CDH1) gene. Hum Mutation 12: 226-237
3. Berx G, Cleton-Jansen AM, Nollet F, de Leeuw WJF, van de Vijver MJ, Cornelisse C, van Roy F (1995a) E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J 14: 6107-6115
4. Berx G, Staes K, van Hengel J, Molemans F, Bussemakers MJG, van Bokhoven A, van Roy F (1995b) Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1). Genomics 26: 281-289
5. Gayther SA, Gorringe KL, Ramus SJ, Huntsman D, Roviello F, Grehan N, Machado JC, Pinto E, Seruca R, Hailing K, MacLeod P, Powell SM, Jackson CE, Ponder BAJ, Caldas C (1998) Identification of germ-line E-cadherin mutations in gastric cancer families of European origin. Cancer Res 58: 4086-4089
6. Guilford P, Hopkins J, Harraway J, McLeod M, McLeod N, Harawira P, Taite H, Scoular R, Miller A, Reeve AE (1998) E-cadherin germline mutations in familial gastric cancer. Nature 392:402-405
7. La Vecchia C, Negri E, Franceschi S, Gentile A (1992) Family history and the risk of stomach and colorectal cancer. Cancer 70: 50-55
8. Shinmura K, Tani M, Isogaki J, Wang Y, Sugimura H, Yokota J (1998) RER phenotype and its associated mutations in familial gastric cancer. Carcinogenesis 19: 247-251
9. Shiozaki H, Oka H, Inoue M, Tamura S, Monden M (1996) E-cadherin mediated adhesion system in cancer cells. Cancer 77: 1605-1613