Downregulation of E-cadherin in the reparative Epithelium of the human gastrointestinal tract

American Journal of Pathology

Volumn 148, Issue 3, 1996, Pages 723-729

  Hanby, Andrew M ^a   Chinery, Rebecca ^b   Poulsom, Richard ^a   Playford, Raymond J ^c   Pignatelli, Massimo ^a,d  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b Royal College of Surgeons

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN;

ARTICLE; CELL CULTURE; CROHN DISEASE; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE MUCOSA; METABOLISM; PATHOPHYSIOLOGY; PEPTIC ULCER; REGENERATION; STOMACH MUCOSA;

CADHERINS; CROHN DISEASE; GASTRIC MUCOSA; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINAL MUCOSA; PEPTIC ULCER; REGENERATION; TUMOR CELLS, CULTURED;

EID: 0030091627     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Svanes K, Itoh S, Takeuchi K, Silen W: Restitution of the surface epithelium of the in vivo frog gastric mucosa after damage with hypermolar sodium chloride. Gastroenterology 1982, 82:1409-1426
2. Playford RJ, Marchbank T, Chinery R, Evison R, Pignatelli M, Bolton R, Thim L, Hanby AM. Human spasmolytic polypeptide is a cytoprotective agent which stimulates cell migration. Gastroenterology 1995, 108: 108-116
3. Chinery R, Playford RJ: Combined intestinal trefoil-factor and epidermal growth factor is prophylactic against indomethacin-induced gastric damage in the rat. 1995 Clin Sci 88.401-403
4. Geiger B, Ayalon O: Cadherins. Annu Rev Cell Biol 1992, 8:307-332
5. Gumbiner B, McCrea PD: Catenins as mediators of the cytoplasmic functions of cadherins J Cell Sci Suppl 1993, 17 155-158
6. Takeichi M: Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991, 251 1451-1455
7. Larue L, Ohsugi M, Hitchenhain J, Kemler R: E-cadherin null mutant embryos fail to form a trophectoderm epithelium Proc Natl Acad Sci USA 1994, 91 8263-8267
8. Pignatelli M: E-cadherin: a biological marker of tumor differentiation. J Pathol 1993, 171.81-82
9. Pignatelli M, Vessey CJ: Adhesion molecules: novel molecular tools in tumor pathology. Hum Pathol 1994, 25 849-856
10. Dorudi S, Sheffield JP, Poulsom R, Northover JMA, Hart IR: E-cadherin expression on colorectal carcinoma an immunocytochemical and in situ hybridization study Am J Pathol 1993, 142:981-986
11. Nigam AK, Savage FJ, Boulos PB, Stamp GWH, Liu D, Pignatelli M Loss of cell-cell and cell-matrix adhesion molecules in colorectal carcinoma. Br J Cancer 1993, 68 507-514
12. Gagliardi G, Kandemir O, Liu D, Guida M, Benvestito S, Ruers TGM, Benjamin IS, Northover JMA, Stamp GWH, Talbot IC, Pignatelli M Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. Virchows Archiv 1995, 426.149-154
13. Takeichi M. Cadherins in cancer. implications for invasion and metastasis. Curr Opin Cell Biol 1993, 5:806-811
14. Umbas R, Isaacs WB, Bringuier PP, Schaafsma HE, Karthaus HF, Oosterhof GO, Debruyne FM, Schalken JA Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer Cancer Res 1994, 54.3929-3933
15. Bringuier PP, Umbas R, Schaafsma HE, Karthaus HF, Debruyne FM, Schalken JA: Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors. Cancer Res 1993, 53.3241-3245
16. Pignatelli M, Ansan TQ, Gunter P, Liu D, Hirano S, Takeichi M, Kloppel G, Lemoine NR: Loss of membranous E-cadherin expression in pancreatic cancer. correlation with lymph node metastasis, high grade and advanced stage. J Pathol 1994, 174:243-248
17. Mattijssen V, Peters HM, Schalkwijk L, Manni JJ, Van-P Hofengrotengrootenboer B, Demulber PHM, Ruiter DJ E-cadherin expression in head and neck squamous-cell carcinoma is associated with clinical outcome Int J Cancer 1993, 55:580-585
18. Dorudi S, Hanby AM, Poulsom R, Northover J, Hart IR: Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome. Brit J Cancer 1995, 71:614-616
19. Behrens J, Mareel MM, Van RF, Birchmeier W: Dissecting tumor cell invasion epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 1989, 108:2435-2449
20. Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato, Takeichi M, Abe O: Cadhenn cell-adhesion molecules in human epithelial tissues Cancer Res 1989, 49:2128-2133
21. Senior PV, Critchley DR, Beck F, Walker RA, Varley JM: The localisation of laminin mRNA and protein in the postimplantation embryo and placenta of the mouse. an in situ hybridization and immunocytochemical study. Development 1988, 104:431-446
22. Shiozaki H, Kadoaki T, Doki Y, Inoue M, Tamura S, Oka H, Iwazawa T, Matsui S, Shimaya K, Takeichi M, Mori T Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line. Br J Cancer 1995, 71:250-258