Promoter-specific activation of gene expression directed by bacteriophage-selected zinc fingers

Journal of Molecular Biology

Volumn 273, Issue 3, 1997, Pages 525-532

  Choo, Y ^a   Castellanos, A ^b   Garcia Hernandez B ^b   Sanchez Garcia I ^b   Klug, A ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

DNA binding protein; Gene therapy; Intermolecular recognition; Phage display; Zinc finger

Indexed keywords

TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; BACTERIOPHAGE; CHO CELL; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANIMALIA; FILAMENTOUS BACTERIOPHAGE; MAMMALIA;

EID: 0031592941     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1339     Document Type: Article

References (35)

1. Brent R., Ptashne M. A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell. 43:1985;729-736.
2. Choo Y., Klug A. Toward a code for the interactions of zinc fingers with DNA: selection of randomised zinc fingers displayed on phage. Proc. Natl Acad. Sci. USA. 91:1994a;11163-11167.
3. Choo Y., Klug A. Selection of DNA binding sites for zinc fingers using rationally randomised DNA reveals coded interactions. Proc. Natl Acad. Sci. USA. 91:1994b;11168-11172.
4. Choo Y., Klug A. Designing DNA-binding proteins on the surface of filamentous phage. Curr. Opin. Biotech. 6:1995;431-436.
5. Choo Y., Sanchez-Garcia I., Klug A. In vivo. Nature. 372:1994;642-645.
6. Christy B., Nathans D. DNA binding site of the growth factor-inducible protein Zif268. Proc. Natl Acad. Sci. USA. 86:1989;8737-8741.
7. de Wet J. R., Wood K. V., de Luca M., Helinski D. R., Subramani S. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell Biol. 7:1987;725-737.
8. Elrod-Erickson M., Rould M. A., Nekludova L., Pabo C. O. Zif268 protein-DNA complex refined at 1.6 Å: a model system for understanding zinc finger interactions. Structure. 4:1996;1171-1180.
9. Evan G. I., Lewis G. K., Ramsay G., Bishop J. M. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol. 5:1985;3610-3616.
10. Fields S. A method for defining DNA-binding activity. Methods. 5:1993;116-124.
11. Gorman C. M., Moffat L. F., Howard B. H. Recombinant genomes which express CAT in mammalian cells. Mol. Cell. Biol. 2:1982;1044-1051.
12. Greisman H. A., Pabo C. O. A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science. 275:1997;657-661.
13. Hayashi S., Scott M. P. What determines the specificity of action of Drosophila homeodomain proteins? Cell. 63:1990;883-894.
14. Herschlag D., Johnson F. B. Synergism in transcriptional activation: a kinetic view. Genes Dev. 7:1993;173-179.
15. Isalan M. D., Choo Y., Klug A. Synergy between adjacent zinc fingers in sequence-specific DNA recognition. Proc. Natl Acad. Sci. USA. 94:1997;5617-5621.
16. Jamieson A. C., Kim S. -H., Wells J. A. In vitro selection of zinc fingers with altered DNA-binding specificity. Biochemistry. 33:1994;5689-5695.
17. Kel O. V., Romaschenko A. G., Kel A. E., Wingender E., Kolchanov N. A. A compilation of composite regulatory elements affecting gene transcription in vertebrates. Nucl. Acids Res. 23:1995;4097-4103.
18. Klug A., Rhodes D. 'Zinc fingers': a novel protein motif for nucleic acid recognition. Trends Biochem. Sci. 12:1987;464-469.
19. Lamb P., McKnight S. L. Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerisation. Trends Biochem. Sci. 16:1991;417-422.
20. Luscher B., Mitchell P. J., Williams T., Tjian R. Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers. Genes Dev. 3:1989;1507-1517.
21. Miller J., McLachlan A. D., Klug A. Repetitive zinc-binding domains in the protein transcription factor IIIA fromXenopus. EMBO J. 4:1985;1609-1614.
22. Milos P. M., Zaret K. S. A ubiquitous factor is required for C/EBP-related proteins to form stable transcription complexes on an albumin promoter segment in vitro. Genes Dev. 6:1992;991-1004.
23. Mitchell P. J., Tjian R. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science. 245:1989;371-378.
24. Mizushima S., Shigezaku N. pEF-BOS, a powerful mammalian expression vector. Nucl. Acids Res. 18:1990;5322.
25. Nikolov D. B., Burley S. K. RNA polymerase II transcription initiation: a structural view. Proc. Natl Acad. Sci. USA. 94:1997;15-22.
26. Pabo C. O., Sauer R. T. Transcription factors: structural families and principles of DNA recognition. Annu. Rev. of Biochem. 61:1992;1053-1095.
27. Ptashne M., Gann A. A. F. Activators and targets. Nature. 346:1990;329-331.
28. Rebar E. J., Pabo C. O. Zinc finger phage: affinity selection of fingers with new DNA-binding specificities. Science. 263:1994;671-673.
29. Reith W., Siegrist C. -A., Durand B., Barras E., Mach B. Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y. Proc. Natl Acad. Sci. USA. 91:1994;554-558.
30. Rivera R. R., Stuiver M. H., Steenbergen R., Murre C. Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression. Mol. Cell. Biol. 13:1993;7163-7169.
31. Roeder R. G. The complexities of eukaryotic transcription initiation: regulation of preinitiation complex assembly. Trends Biochem. Sci. 16:1991;402-408.
32. Sadowski I., Brendan B., Broad P., Hollis M. Gal 4 fusion vectors for expression in yeast or mammalian cells. Gene. 118:1992;137-141.
33. Shyam E., Reddy P., Rao V. N. A eukaryotic vector for the expression of genes or gene fragments. Gene Anal. Tech. 3:1986;41-44.
34. Swirnoff A. H., Milbrandt J. DNA-binding specificity of NGFI-A and related zinc finger transcription factors. Mol. Cel. Biol. 15:1995;2275-2287.
35. 26. J. Biol. Chem. 268:1993;24699-24706.