Secondary mutation maintains the transformed state in BaF3 cells with inducible BCR/ABL expression

Blood

Volumn 91, Issue 10, 1998, Pages 3927-3934

  Klucher, Kevin M ^a   Lopez, David V ^a   Daley, George Q ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC STABILITY; HUMAN; HUMAN CELL; LEUKEMOGENESIS; LYMPHOCYTE TRANSFORMATION; MALIGNANT TRANSFORMATION; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 0032525270     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.10.3927     Document Type: Article

References (39)

1. Fialkow PJ, Jacobson RJ, Papayannopoulou T: Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med 63:125, 1977
2. Nowell PC, Hungerford DA: A minute chromosome in human chronic granulocytic leukemia. Science 132:1497, 1960
3. Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G: Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 36:93, 1984
4. de Klein A, van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, Spurr NK, Heisterkamp N, Groffen J, Stephenson JR: A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature 300:765, 1982
5. Shtivelman E, Lifshitz B, Gale RP, Canaani E: Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 315:550, 1985
6. Daley GQ, Baltimore D: Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci USA 85:9312, 1988
7. Laneuville P, Heisterkamp N, Groffen J: Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line. Oncogene 6:275, 1991
8. Goga A, McLaughlin J, Afar DEH, Saffran DC, Witte ON: Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene. Cell 82:981, 1995
9. Hariharan IK, Harris AW, Crawford M, Abud H, Webb E, Cory S, Adams JM: A bcr-v-abl oncogene induces lymphomas in transgenic mice. Mol Cell Biol 9:2798, 1989
10. Heisterkamp N, Jenster G, the Hoeve J, Zovich D, Pattengale PK, Groffen J: Acute leukaemia in bcr/abl transgenic mice. Nature 344:251, 1990
11. Honda H, Fujii T, Takatoku M, Mano H, Witte ON, Yazaki Y, Hirai H: Expression of P210 BCR/ABL by metallothionein promoter induced T-cell leukemia in transgenic mice. Blood 85:2853, 1995
12. Afar DEH, Goga A, McLaughlin J, Witte ON, Sawyers CL: Differential complementation of BCR-ABL point mutants with c-myc. Science 264:424, 1994
13. Pendergast A, Quilliam LA, Cripe LD, Bassing CH, Dai Z, Li N, Batzer A, Rabun KM, Der CJ, Schlessinger J, Gishizky M: BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 75:175, 1993
14. Carlesso N, Frank DA, Griffen JD: Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by BCR/ABL. J Exp Med 183:811, 1996
15. Ilaria RL Jr, Van Etten RA: P210 and P190 BCR/ABL induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem 271:31704, 1996
16. Ahuja H, Bar-Eli M, Arlin Z, Advani S, Allen SL, Goldman J, Snyder D, Foti A, Cline M: The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia. J Clin Invest 87:2042, 1991
17. Foti A, Ahuja HG, Allen SL, Koduru P, Schuster MW, Schulman P, Bar-Eli M, Cline MJ: Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis. Blood 77:2441, 1991
18. Nakai H, Misawa S, Toguchida J, Yandell DW, Ishizaki K: Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p. Cancer Res 52:6588, 1992
19. Neubauer A, He M, Schmidt CA, Huhn D, Liu ET: Genetic alterations in the p53 gene in the blast crisis of chronic myelogenous leukemia: Analysis by polymerase chain reaction based techniques. Leukemia 7:593, 1993
20. Sill H, Goldman JM, Cross NC: Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood 85:2013, 1995
21. Bi S, Barton CM, Lemoine NR, Cross NC, Goldman JM: Retroviral transduction of Philadelphia-positive chronic myeloid leukemia cells with a human mutant p53 cDNA and its effect on in vitro proliferation. Exp Hematol 22:95, 1994
22. Skorski T, Nieborowska-Skorska M, Wlodarski P, Perrotti D, Martinez R, Wasik MA, Calabretta B: Blastic transformation of p53-deficient bone marrow cells by p210bcr/abl tyrosine kinase. Proc Natl Acad Sci USA 93:13137, 1996
23. Laneuville P, Sun G, Timm M, Vekemans M: Clonal evolution in a myeloid cell line transformed to interleukin-3 independent growth by retroviral transduction and expression of p210bcr/abl. Blood 80:1788, 1992
24. McGahon A, Bissonnette R, Schmitt M, Cotter KM, Green DR, Cotter TG: BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. Blood 83:1179, 1994
25. Bedi A, Barber JP, Bedi GC, el-Deiry WS, Sidransky D, Vala MS, Akhtar AJ, Hilton J, Jones RJ: BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents. Blood 86:1148, 1995
26. Kabarowski J, Allen P, Wiedemann L: A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells. EMBO J 13:5887, 1994
27. Carlesso N, Griffin J, Druker B: Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line. Oncogene 9:149, 1994
28. Daley GQ, Van Etten RA, Baltimore D: Induction of chronic myelogenous leukemia in mice by the P210 BCR/ABL gene of the Philadelphia chromosome. Science 247:824, 1990
29. Shockett P, Difilippantonio M, Hellman N, Schatz DG: A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc Natl Acad Sci USA 92:6522, 1995
30. Gossen M, Freundlieb S, Bender G, Mueller G, Hillen W, Bujard H: Transcriptional activation by tetracyclines in mammalian cells. Science 268:1766, 1995
31. Palacios R, Steinmetz M: IL3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell 41:727, 1985
32. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55, 1983
33. Gossen M, Bujard H: Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547, 1992
34. Ewald D, Li M, Efrat S, Auer G, Wall RJ, Furth PA, Hennig-hausen L: Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen. Science 273:1384, 1996
35. Griffiths SD, Healy LE, Ford AM, Bennett CA, Voncken JW, Heisterkamp N, Groffen J, Greaves MF: Clonal characteristics of acute lymphoblastic cells derived from BCR/ABL p 190 transgenic mice. Oncogene 7:1391, 1992
36. Voncken JW, Morris C, Pattengale P, Dennert G, Kikly C, Groffen J, Heisterkamp N: Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice. Blood 79:1029, 1992
37. McLaughlin J, Chianese E, Witte ON: In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome. Proc Natl Acad Sci USA 84:6558, 1987
38. Gishizky ML, Johnson-White J, Witte ON: Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice. Proc Natl Acad Sci USA 90:3755, 1993
39. Kelliher MA, McLaughlin J, Witte ON, Rosenberg N: Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc Natl Acad Sci USA 87:6649, 1990