Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae

EMBO Reports

Volumn 3, Issue 1, 2002, Pages 95-100

  Vainio, Saara ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CAVEOLIN; CHOLESTEROL; CYCLODEXTRIN; DETERGENT; GANGLIOSIDE GM2; GLYCOSPHINGOLIPID; INSULIN RECEPTOR; LIGAND; LIPID; SPHINGOLIPID;

ADIPOCYTE; ARTICLE; AUTOPHOSPHORYLATION; CAVEOLA; CELL MEMBRANE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; LIVER; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN INTERACTION; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TARGET ORGAN;

CAVEOLAE; CHOLESTEROL; GLYCOSPHINGOLIPIDS; HUMANS; LIVER; MEMBRANE MICRODOMAINS; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0036166283     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf010     Document Type: Article

References (27)

1. Morphologic and functional characterization of caveolae in rat liver hepatocytes
2. Redistribution of 125I-insulin on the surface of rat hepatocytes as a function of dissociation time
3. Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation
4. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
5. Cholesterol and caveolae: Structural and functional relationships
6. Localization of the insulin receptor in caveolae of adipocyte plasma membrane
7. Lipid domain structure of the plasma membrane revealed by patching of membrane components
8. Myristyl and palmityl acylation of the insulin receptor
9. Receptor aggregation is necessary for activation of the soluble insulin receptor kinase
10. Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface
11. Signal transduction in leucocytes via GPI-anchored proteins: An experimental artefact or an aspect of immunoreceptor function?
12. Crystal structure of the tyrosine kinase domain of the human insulin receptor
13. Aggregation of lipid rafts accompanies signalling via the T cell antigen receptor
14. Insulin receptors: Differences in structural organization on adipocyte and liver plasma membranes
15. The interaction of insulin with its receptor: Cross-linking via insulin association as the source of receptor clustering
16. Characterization of the binding epitope of the monoclonal antibody DMAb-1 to ganglioside GM2
17. Possible roles of glycosphingolipids in lipid rafts
18. Insolubility of lipids in Triton X-100: Physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts)
19. Insulin and IGF-1 receptors contain covalently bound palmitic acid
20. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium
21. Caveolin-1 interacts with the insulin receptor and can differentially modulate insulin signalling in transfected Cos-7 cells and rat adipose cells
22. Mechanism of transmembrane signalling: Insulin binding and the insulin receptor
23. Cholesterol depletion disrupts caveolae and insulin receptor signalling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control
24. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
25. Lipid rafts and signal transduction
26. The insulin signalling system
27. Caveolin is an activator of insulin receptor signalling