Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats

Endocrinology

Volumn 137, Issue 1, 1996, Pages 151-159

  Carvalho, Carla R O ^a   Brenelli, Sigisfredo L ^a   Silva, Ana C ^a   Nunes, Andre L B ^a   Velloso, Licio A ^a   Saad, Mario J A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL KINASE; RECEPTOR SUBUNIT;

AGING; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HORMONE ACTION; INSULIN RESISTANCE; LIVER LEVEL; MUSCLE LEVEL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0030066985     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.1.8536607     Document Type: Article

References (45)

1. Barnard RJ, Lawani LO, Martin DA, Youngren JF, Singh R, Scheck SH 1992 Effects of maturation and aging on the skeletal glucose transport system. Am J Physiol 262:E619-E626
2. Fink RI, Kolterman OG, Griffin J, Backer JM, Olefsky JM 1983 Mechanisms of insulin resistance in aging. J Clin Invest 71:1523-1535
3. Goodman NM, Dluz SM, McElaney MA, Belur E, Ruderman NB 1983 Glucose uptake and insulin sensitivity in rat muscle: change during 3-96 weeks of age. Am J Physiol 244:E93-E100
4. Gulve EA, Henriksen EJ, Rodnick KJ, Youn JH, Holloszy JO 1993 Glucose transporters and glucose transport in skeletal muscle of 1-to 25 mo-old rats. Am J Physiol 264:E319-E327
5. Reed MJ, Reaven GM, Mondon CE, Azhar S 1993 Why does insulin resistance develop during maturation? J Gerontol 48:B139-B144
6. Yoshimasa Y, Yamada K, Ida T, Kakehi T, Imura H 1988 Change of insulin action with aging in conscious rats determined by euglycemic clamp. Am J Physiol 254:E92-E98
7. Kono S, Kuzuya H, Okamoto M, Nishimura H, Kosaki A, Kakehi T, Inove G, Maeda I, Imura H 1990 Changes in receptor kinase with aging in rat skeletal muscle and liver. Am J Physiol 259:E27-E35
8. Carrascosa JM, Ruiz P, Martinez C, Pulido JA, Satrustegui J, Andres A 1989 Insulin receptor kinase activity in rat adipocytes is decreased during aging. Biochem Biophys Res Commun 160:303-309
9. Nadiv O, Cohen O, Zick Y 1992 Defects of insulin's signal transduction in old rat livers. Endocrinology 130:1515-1524
10. Kern M, Dolan PL, Mazzeo RS, Wells JA, Dohn GL 1992 Effects of aging and exercise on GLUT-4 glucose transporters in muscle. Am J Physiol 263:E362-E367
11. White MF, Kahn CR 1994 The insulin signaling system. J Biol Chem 269:1-5
12. Ebina Y, Araki E, Taira M, Shimada F, Mori M, Craik CS, Siddle K, Pierce SB, Roth RA, Rutter WJ 1987 Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proc Natl Acad Sci USA 84:704-708
13. Chou CK, Dull TJ, Russel DS, Gherzi R, Lewohl D, Ullrich A, Rosen OM 1987 Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin. J Biol Chem 262:1842-1847
14. White MF, Maron R, Kahn CR 1985 Insulin rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells. Nature 318:183-186
15. Maegawa H, Olefsky JM, Thies S, Boyd D, Ullrich A, McClain MA 1988 Insulin receptor with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation. J Biol Chem 261:16597-16603
16. Momomura K, Tobe K, Seyama Y, Takaku F, Akanuma Y, Kasuga M 1987 Insulin-induced tyrosine phosphorylation in intact rat adipocytes. Biochem Biophys Res Commun 155:1181-1186
17. Sun XJ, Rothenberg PL, Kahn CR, Backer JM, Araki E, Wilden P, Cahill DA, Goldstein BJ, White MF 1991 Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (Lond) 352:73-77
18. Lamphere L, Carpenter CL, Sheng ZF, Kallen RG, Lienhard G E 1994 Activation of PI 3-kinase in 3T3-L1 adipocytes by association with insulin receptor substrate-1. Am J Physiol 266:E486-E494
19. Backer JM, Myers Jr MG, Schoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, White MF 1992 The phosphatidylinositol 3-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J 11:3469-3479
20. Folli F, Saad MJA, Backer JM, Kahn CR 1993 Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin resistance and insulin-deficient diabetes mellitus. J Clin Invest 92:1787-1794
21. Saad MJA, Folli F, Kahn JA, Kahn CR 1993 Modulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. J Clin Invest 92:2065-2072
22. Laemmili UK 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond) 227:680-685
23. Towbin H, Staehlin J, Gordon J 1979 Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354
24. Yamauchi K, Milarski KL, Saltiel AR, Pessin JE 1995 Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc Natl Acad Sci USA 92:664-668
25. Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekchara H, Yoshioka S, Horlkoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S 1994 Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372:182-186
26. Araki E, Lipes MA, Patti MA, Bruning JC, Haag B, Johnson RS, Kahn CR 1994 Alternative pathway of insulin signaling in mice with target disruption of the IRS-1 gene. Nature 372:186-190
27. Giorgetti S, Balloti R, Kowalski-Chawel A, Tartare S, VanObberghen E 1993 The insulin and insulin-like growth factor-1 receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro. J Biol Chem 268:7358-7364
28. Hadari YR, Tzahar E, Nadiv O, Rothenberg P, Roberts CT, LeRoith D, Yarden Y, Zick Y 1992 Insulin and insulinominetic agents induce activation of phosphatidylinositol 3-kinase upon its association with pp185 (IRS-1) in intact rat livers. J Biol Chem 267:17483-17486
29. Lavan BE, Kuhne MR, Garner CW, Anderson D, Rudijk M, Pawson T, Lienhard GE 1992 The association of insulin-elicited phosphotyrosine proteins with src homology domains. J Biol Chem 267:11631-11636
30. Kelly KL, Ruderman NB 1993 Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle. J Biol Chem 268:4391-4398
31. Sun XJ, Miralpeix M, Myers Jr MG, Glasheen EM, Backer JM, Kahn CR, White M F 1992 Expression and function of IRS-1 in insulin signal transmission. J Biol Chem 267:22662-22672
32. 2-containing phosphotyrosine phosphatase Syp. J Biol Chem 268:11479-11481
33. Pawson T 1995 Protein modules and signaling networks. Nature 373:573-580
34. Ruderman NB, Kapeller R, White MF, Cantley LC 1990 Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci USA 87:1411-1415
35. Mathaei S, Benecke H, Klein HH, Hamann A, Kreymann G, Greten G 1990 Potential mechanism of insulin resistance in aging: impaired insulin-stimulated glucose transport due to a depletion of intracellular pool of glucose transporters in Fischer rat adipocytes. J Endocrinol 126:99-107
36. Giorgino F, Almahfouz A, Goodyear LJ, Smith RJ 1993 Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo. J Clin Invest 91:2020-2030
37. Rice KM, Garner GR 1994 Correlation of the insulin receptor substrate-1 with insulin-responsive deoxyglucose transport in 3T3-l1 adipocytes. Biochem Biophys Res Commun 198:523-530
38. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR 1994 Phosphatidylinositol 3/kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cel Biol 14:4902-4911
39. Quon MJ, Butte AJ, Zarnowski MJ, Sesti G, Cushman SW, Taylor SI 1995 Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells. J Biol Chem 269: 27920-27924
40. Kanai F, Ito K, Todaka M, Hayashi H, Kamohara S, Ishii K, Okada T, Hazeki O, Ebina Y 1993 Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI 3-kinase. Biochem Biophys Res Commun 195:762-768
41. Nadiv O, Shinitzky M, Manu H, Hecht D, Roberts Jr CT, LeRoith D, Zick Y 1994 Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats. Biochem J 298:443-450
42. Zoppini G, Kahn CR 1992 Effect of phospholipase treatment on insulin receptor signal transduction. Diabetologia 35:109-115
43. Olefsky JM, Reaven GM 1975 Effects of age and obesity on insulin binding to isolates adipocytes. Endocrinology 96:1486-1498
44. Davidson MB, Karjala R G 1978 Primary insulin antagonism of glucose transport in muscle from the older-obese rat. Metabolism 27:1994-2005
45. Saad MJA, Araki E, Miralpeix M, Rothenberg PL, White MF, Kahn CR 1992 Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest 90:1839-1849