Age-Related Changes in the Function of T Cells

Microscopy Research and Technique

Volumn 62, Issue 6, 2003, Pages 508-513

  Aspinall, Richard ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

Repertoire; Senescence; Signaling; Telomere; Thymus

Indexed keywords

CELL SIGNALING; DETERIORATION; DISEASES; T-CELLS;

AGE-RELATED CHANGES; REPERTOIRE; RESPIRATORY TRACT; SENESCENCE; SIGNALING; SOFT TISSUE; SURVIVAL CURVES; TELOMERES; UNITED KINGDOM; URINARY TRACT;

IMMUNE SYSTEM;

INTERLEUKIN 7; LECTIN RECEPTOR; PRASTERONE SULFATE;

ABDOMINAL INFECTION; AGING; ARTICLE; BACTERIAL ENDOCARDITIS; BACTERIAL MENINGITIS; CARCINOMA; CELL FUNCTION; CELL MATURATION; CELLULAR DISTRIBUTION; HERPES ZOSTER; HUMAN; INCIDENCE; KILLER CELL; MORBIDITY; MORTALITY; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; SENESCENCE; SIGNAL TRANSDUCTION; SKIN INFECTION; SOFT TISSUE INFECTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYMUS ATROPHY; TUBERCULOSIS; URINARY TRACT INFECTION;

BACTERIA (MICROORGANISMS);

EID: 0344153741     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.10412     Document Type: Article

References (63)

1. Aggrawal S, Tsuruo T, Gupta S. 1997. Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR 1 gene, in T cell subsets from aging humans. J Clin Immunol 17:448-454.
2. Anderson G, Moore NC, Owen JJ, Jenkinson EJ. 1996. Cellular interactions in thymocyte development. Annu Rev Immunol 14:73-99.
3. Andrew D, Aspinall R. 2001. IL-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J Immunol 166:1524-1530.
4. Andrew D, Aspinall R. 2002. Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp Gerontol 37:455-463.
5. Aspinall R. 1997. Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J Immunol 158:3037-3045.
6. Aspinall R, Andrew D. 2000. Thymic atrophy in the mouse is a soluble problem of the thymic microenvironment. Vaccine 18:1629-1638.
7. Aspinall R, Andrew D. 2001. Age-associated thymic atrophy is not associated with a deficiency in the CD44(+)CD25(-)CD3(-) CD4(-)CD8(-) thymocyte population; Cell Immunol 212:150-157.
8. Azuma M, Phillips JH, Lanier LL. 1993. CD28-T lymphocytes. Antigenic and functional properties. J Immunol 150:1147-1159.
9. Cossarizza A, Ortolani C, Paganelli R, Barbieri D, Monti D, Sansoni P, Fagiolo U, Castellani G, Bersani F, Londei M, Franceschi C. 1996. CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory. Mech Ageing Dev 86:173-195.
10. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA. 1998. Changes in thymic function with age and during the treatment of HIV infection [see comments]. Nature 396:690-695.
11. Farr AG, Sidman CL. 1984. Reduced expression of Ia antigens by thymic epithelial cells of aged mice. J Immunol 133:98-103.
12. Flurkey K, Miller RA, Harrison DE. 1992a. Cellular determinants of age-related decrements in the T-cell mitogen response of B6CBAF1 mice. J Gerontol 47:B115-20.
13. Flurkey K, Stadecker M, Miller RA. 1992b. Memory T lymphocyte hyporesponsiveness to non-cognate stimuli: a key factor in age-related immunodeficiency. Eur J Immunol 22:931-935.
14. Foad BS, Adams LE, Yamauchi Y, Litwin A. 1974. Phytomitogen responses of peripheral blood lymphocytes in young and older subjects. Clin Exp Immunol 17:657-664.
15. Gershon H, Merhav S, Abraham C. 1979. T-cell division and aging. Mech Ageing Dev 9:27-38.
16. Godfrey DI, Zlotnik A, Suda T. 1992. Phenotypic and functional characterization of c-kit expression during intrathymic T cell development. J Immunol 149:2281-2285.
17. Godfrey DI, Kennedy J, Suda T, Zlotnik A. 1993. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol 150:4244-4252.
18. Godfrey DI, Kennedy J, Mombaerts P, Tonegawa S, Zlotnik A. 1994. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol 152:4783-4792.
19. Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof Garde SR, Klein MR, van Lier RA. 1997. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 186:1407-1418.
20. Hannet I, Erkeller Yuksel F, Lydyard P, Deneys V, DeBruyere M. 1992. Developmental and maturational changes in human blood lymphocyte subpopulations [see comments]. Immunol Today 13:215-218.
21. Hooijberg E, Ruizendaal JJ, Snijders PJ, Kueter EW, Walboomers JM, Spitz H. 2000. Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase. J Immunol 165:4239-4245.
22. Hulstaert F, Hannet I, Deneys V, Munhyeshuli V, Reichert T, De Bruyere M, Strauss K. 1994. Age-related changes in human blood lymphocyte subpopulations. II. Varying kinetics of percentage and absolute count measurements Age-related changes in human blood lymphocyte subpopulations. Clin Immunol Immunopathol 70:152-158.
23. Jameson SC, Hogquist KA, Bevan MJ. 1995. Positive selection of thymocytes. Annu Rev Immunol 13:93-126.
24. Jamieson BD, Douek DC, Killian S, Hultin LE, Scripture Adams DD, Giorgi JV, Marelli D, Koup RA, Zack JA. 1999. Generation of functional thymocytes in the human adult. Immunity 10:569-575.
25. Kipling D. 1997. Telomere structure and telomerase expression during mouse development and tumorigenesis. Eur J Cancer 33:792-800.
26. Ku CC, Murakami M, Sakamoto A, Kappler J, Marrack P. 2000. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288:675-678.
27. Ku CC, Kappler J, Marrack P. 2001. The growth of the very large CD8+ T cell clones in older mice is controlled by cytokines. J Immunol 166:2186-2193.
28. Long E. 1999. Regulation of Immune responcses through inhibitory receptors. Annu Rev Immunol 17:875-904.
29. Makinodan T. 1998. Studies on the influence of age on immune response to understand the biology of immunosenescence. Exp Gerontol 33:27-38.
30. Markert ML, Boeck A, Hale LP, Kloster AL, McLaughlin TM, Batchvarova MN, Douek DC, Koup RA, Kostyu DD, Ward FE, Rice HE, Mahaffey SM, Schiff SE, Buckley RH, Haynes BF. 1999. Transplantation of thymus tissue in complete DiGeorge syndrome [see comments]. N Engl J Med 341:1180-1189.
31. McFarland RD, Douek DC, Koup RA, Picker LJ. 2000. Identification of a human recent thymic emigrant phenotype. Proc Natl Acad Sci USA 97:4215-4220.
32. Mclean AR, Michie CA. 1995. In vivo estimates of division and death rates of human T lymphocytes. Proc Natl Acad Sci USA 92:3707-3711.
33. Miller RA. 2000. Effect of aging on T lymphocyte activation. Vaccine 18:1654-1660.
34. Miller RA, Chrisp C. 1999. Lifelong treatment with oral DHEA sulfate does not preserve immune function, prevent disease, or improve survival in genetically heterogeneous mice. J Am Geriatr Soc 47:960-966.
35. Moore NC, Anderson G, Smith CA, Owen JJ, Jenkinson EJ. 1993. Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction. Eur J Immunol 23:922-927.
36. Mosley RL, Koker MM, Miller RA. 1998. Idiosyncratic alterations of TCR size distributions affecting both CD4 and CD8 T cell subsets in aging mice. Cell Immunol 189:10-18.
37. Murasko DM, Weiner P, Kaye D. 1987. Decline in mitogen induced proliferation of lymphocytes with increasing age Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin Exp Immunol 70:440-448.
38. Nociari MM, Telford W, Russo C. 1999. Postthymic development of CD28-CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype. J Immunol 162:3327-3335.
39. Pawelec G, Sansom D, Rehbein A, Beckman I. 1996. Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human CD4+ TCR2+ cultured T cell clones. Exp Gerontol 31:655-658.
40. Perillo NL, Naeim F, Walford RL, Effros RB. 1993. In vitro cellular aging in T-lymphocyte cultures: analysis of DNA content and cell size. Exp Cell Res 207:131-135.
41. Rahemtulla A, Fung Leung WP, Schilham MW, Kundig TM, Sambhara SR, Narendran A, Arabian A, Wakeham A, Paige CJ, Zinkernagel RM, Miller RG, Mak TW. 1991. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353:180-184.
42. Raulet DH, Vance RE, McMahon CW. 2001. Regulation of the natural killer cell receptor repertoire. Annu Rev Immunol 19:291-330.
43. Rocha B, Dautigny N, Pereira P. 1989. Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur J Immunol 19:905-911.
44. Rufer N, Migliaccio M, Antonchuk J, Humphries RK, Roosnek E, Lansdorp PM. 2001. Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood 98:597-603.
45. Sempowski GD, Hale LP, Sundy JS, Massey JM, Koup RA, Douek DC, Patel DD, Haynes BF. 2000. Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J Immunol 164:2180-2187.
46. Sprent J, Tough DF. 2001. T cell death and memory. Science 293:245-248.
47. Takayama E, Seki S, Ohkawa T, Ami K, Habu Y, Yamaguchi T, Tadakuma T, Hiraide H. 2000. Mouse CD8+ CD122+ T cells with intermediate TCR increasing with age provide a source of early IFN-gamma production. J Immunol 164:5652-5658.
48. Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells [see comments]. Science 276:2057-2062.
49. Tough DF, Zhang X, Sprent J. 2001. An IFN-gamma-dependent pathway controls stimulation of memory phenotype CD8+ T cell turnover in vivo by IL-12, IL-18, and IFN-gamma. J. Immunol. 166, 6007-6011.
50. Utsuyama M, Hirokawa K, Kurashima C, Fukayama M, Inamatsu T, Suzuki K, Hashimoto W, Sato K. 1992. Differential age-change in the numbers of CD4+CD45RA+ and CD4+CD29+ T cell subsets in human peripheral blood Differential age-change in the numbers of CD4+CD45RA+ and CD4+CD29+ T cell subsets in human peripheral blood. Mech Ageing Dev 63:57-68.
51. Utsuyama M, Varga Z, Fukami K, Homma Y, Takenawa T, Hirokawa K. 1993. Influence of age on the signal transduction of T cells in mice. Int Immunol 5:1177-1182.
52. Utsuyama M, Wakikawa A, Tamura T, Nariuchi H, Hirokawa K. 1997. Impairment of signal transduction in T cells from old mice. Mech Ageing Dev 93:131-144.
53. Vallejo AN, Nestel AR, Schirmer M, Weyand CM, Goronzy JJ. 1998. Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity. J Biol Chem 273:8119-8129.
54. Voehringer D, Kaufmann M, Pircher M. 2001. Genomic structure, alternative splicing, and physical mapping of the killer cell lectin-like receptor G1 gene (KLRG1), the mouse homologue of MAFA. Immunogenetics 52:206-211.
55. Weekes MP, Carmichael AJ, Wills MR, Mynard K, Sissons JG. 1999a. Human CD28-CD8+ T cells contain greatly expanded functional virus-specific memory CTL clones. J Immunol 162:7569-7577.
56. Weekes MP, Wills MR, Mynard K, Hicks R, Sissons JG, Carmichael AJ. 1999b. Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57+ CD28- CD8+ T-cell population. Immunology 98:443-449.
57. Wills MR, Carmichael AJ, Weekes MP, Mynard K, Okecha G, Hicks R, Sissons JG. 1999. Human virus-specific CD8+ CTL clones revert from CD45ROhigh to CD45RAhigh in vivo: CD45RAhighCD8+ T cells comprise both naive and memory cells. J Immunol 162:7080-7087.
58. Witkowski JM, Miller RA. 1993. Increased function of P-glycoprotein in T lymphocyte subsets of aging mice. J Immunol 150:1296-1306.
59. Witkowski JM, Miller RA. 1999. Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein. Mech Ageing Dev 107:165-180.
60. Witkowski JM, Li SP, Gorgas G, Miller RA. 1994. Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production. J Immunol 153:658-665.
61. Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. 1991. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349:71-74.
62. Yoshikawa 2000. Epidemiology and unique aspects of aging and infectious diseases. Clin Infect Dis 30:931-933.
63. Zhang X, Sun S, Hwang I, Tough DF, Sprent J. 1998. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8:591-599.