Age-associated thymic atrophy is not associated with a deficiency in the CD44+CD25-CD3-CD4-CD8- thymocyte population

Cellular Immunology

Volumn 212, Issue 2, 2001, Pages 150-157

  Aspinall, Richard ^a   Andrew, Deborah ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE ANTIBODY; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 7; INTERLEUKIN 7 ANTIBODY; UNCLASSIFIED DRUG;

AGING; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; FEMALE; IN VITRO STUDY; LYMPHOBLAST; MALE; MOUSE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; THYMUS ATROPHY;

ANIMALIA;

EID: 0035885872     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1006/cimm.2001.1848     Document Type: Article

References (32)

1. Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice
2. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy
3. The role of thymus in the aging of Th cell subpopulations and age-associated alteration of cytokine production by these cells
4. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus
5. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD 4
6. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression
7. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation
8. Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes
9. Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression
10. Positive selection of thymocytes
11. T-cell-receptor affinity and thymocyte positive selection
12. Expansion of mature thymocyte subsets before emigration to the periphery
13. Age-related decrease in mouse T cell progenitors
14. Impaired thymic regeneration in lethally irradiated mice given bone marrow from aged donors
15. Thymic function in young/old chimeras: Substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution
16. Aging of the recipients but not of the bone marrow donors enhances autoimmunity in syngeneic radiation chimeras
17. Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development
18. Thymocyte progenitors in ageing
19. Aging in the T lymphocyte compartment. A developmental view
20. Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: Application in the production of chimeric thymus rudiments
21. Leukemia inhibitory factor oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy
22. Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice
23. Thymocyte progenitors and T cell development in aging
24. Age-related changes in the capacity of bone marrow cells to differentiate in thymic organ cultures
25. IL-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice
26. The effect of in vivo IL-7 deprivation on T cell maturation
27. Interleukin-7 expression during mouse thymus development
28. Interferons alpha/beta inhibit IL-7-induced proliferation of CD4-CD8-CD3-CD44+ CD25+ thymocytes, but do not inhibit that of CD4-CD8-CD3-CD44-CD25- thymocytes
29. Differential disposition of soluble and liposome-formulated human recombinant interleukin-7: Effects on blood lymphocyte population in guinea pigs
30. Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+/ -precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture
31. Long-term culture of triple-negative thymocytes
32. The trophic action of IL-7 on pro-T cells: Inhibition of apoptosis of pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways