Thymic atrophy in the mouse is a soluble problem of the thymic environment

Vaccine

Volumn 18, Issue 16, 2000, Pages 1629-1637

  Aspinall, Richard ^a   Andrew, Deborah ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

AGING; AUTOIMMUNE DISEASE; CANCER; DISEASE PREDISPOSITION; GENE REARRANGEMENT; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; INFECTION RISK; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; REVIEW; THYMUS ATROPHY; TRANSGENIC MOUSE;

AGING; ANIMALS; ATROPHY; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; INTERLEUKIN-7; MICE; MODELS, BIOLOGICAL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 0033954359     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00498-3     Document Type: Article

References (68)

1. Office of National Statistics, 1997.
2. The Government Actuary's Department, 1992.
3. Gardner I.D. The effect of aging on susceptibility to infection. Rev. Infect. Dis. 2:(5):1980;801-810.
4. Flurkey K., Miller R.A., Harrison D.E. Cellular determinants of age-related decrements in the T-cell mitogen response of B6CBAF1 mice. J. Gerontol. 47:(4):1992;B115-B120.
5. Bloom E.T., Horvath J.A. Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity. Implications for the age-related decline in CTL. J. Immunol. 152:(9):1994;4242-4254.
6. Hulstaert F., Hannet I., Deneys V., Munhyeshuli V., Reichert T., De Bruyere M., Strauss K. Age-related changes in human blood lymphocyte subpopulations. II. Varying kinetics of percentage and absolute count measurements Age-related changes in human blood lymphocyte subpopulations. II. Varying kinetics of percentage and absolute count measurements. Clin. Immunol. Immunopathol. 70:(2):1994;152-158.
7. Hannet I, Erkeller Yuksel F, Lydyard P, Deneys V, DeBruyere M. Developmental and maturational changes in human blood lymphocyte subpopulations [see comments]. Immunol Today 1992; 13(6):215,218.
8. Utsuyama M., Hirokawa K. Age-related changes of splenic T cells in mice-a flow cytometric analysis. Mech. Ageing. Dev. 40:(1):987;89-102.
9. Mackall C.L., Fleisher T.A., Brown M.R., Andrich M.P., Chen C.C., Feuerstein I.M., Horowitz M.E., Magrath I.T., Shad A.T., Steinberg S.M., et al. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy [see comments]. N. Engl. J. Med. 332:(3):1995;143-149.
10. Mackall C.L., Gress R.E. Thymic aging and T-cell regeneration. Immunol. Rev. 160:1997;91-102.
11. Kampinga J., Groen H., Klatter F.A., Pater J.M., van Petersen A.S., Roser B., Nieuwenhuis P., Aspinall R. Post-thymic T-cell development in the rat. Thymus. 24:(3):1997;173-200.
12. Schwab R., Hausman P.B., Rinnooy Kan E., Weksler M.E. Immunological studies of ageing. X. Impaired T lymphocytes and normal monocyte response from elderly humans to the mitogenic antibodies OKT3 and Leu 4. Immunology. 55:(4):1985;677-684.
13. Zhou T., Edwards C.K., Mountz J.D. Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice [see comments]. J. Exp. Med. 182:(1):1995;129-137.
14. Hobbs M.V., Ernst D.N., Torbett B.E., Glasebrook A.L., Rehse M.A., McQuitty D.N., Thoman M.L., Bottomly K., Rothermel A.L., Noonan D.J., et al. Cell proliferation and cytokine production by CD4+ cells from old mice. J. Cell Biochem. 46:(4):1991;312-320.
15. Murasko D.M., Weiner P., Kaye D. Decline in mitogen induced proliferation of lymphocytes with increasing age Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin. Exp. Immunol. 70:(2):1987;440-448.
16. Wu L., Scollay R., Egerton M., Pearse M., Spangrude G.J., Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature. 349:(6304):1991;71-74.
17. Godfrey D.I., Kennedy J., Suda T., Zlotnik A. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8-triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150:(10):1993;4244-4252.
18. Godfrey D.I., Kennedy J., Mombaerts P., Tonegawa S., Zlotnik A. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J. Immunol. 152:(10):1994;4783-4792.
19. Jameson S.C., Hogquist K.A., Bevan M.J. Positive selection of thymocytes. Annu. Rev. Immunol. 13:1995;93-126.
20. Brandle D., Muller C., Rulicke T., Hengartner H., Pircher H. Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression. Proc. Natl. Acad. Sci. USA. 89:(20):1992;9529-9533.
21. Petrie H.T., Livak F., Schatz D.G., Strasser A., Crispe I.N., Shortman K. Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes. J. Exp. Med. 178:(2):1993;615-622.
22. Alam S.M., Travers P.J., Wung J.L., Nasholds W., Redpath S., Jameson S.C., Gascoigne N.R. T-cell-receptor affinity and thymocyte positive selection [see comments]. Nature. 381:(6583):1996;616-620.
23. Penit C., Vasseur F. Expansion of mature thymocyte subsets before emigration to the periphery. J. Immunol. 159:(10):1997;4848-4856.
24. Kendall M.D., Johnson H.R., Singh J. The weight of the human thymus gland at necropsy. J. Anat. 131:(3):1980;483-497.
25. Aspinall R. Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J. Immunol. 158:(7):1997;3037-3045.
26. Bertho J.M., Demarquay C., Moulian N., Van De Meeren A., Berrih-Akhnin S., Gourmelon P. Phenotypic and immunohistological analyses of the human adult thymus: evidence for an active thymus during adult life. Cellular immunology. 179:(1):1997;30-40.
27. Hirokawa K., Makinodan T. Thymic involution: effect on T cell differentiation. J. Immunol. 114:(6):1975;1659-1664.
28. Smith S.M., Ossa Gomez L.J. A quantitative histologic comparison of the thymus in 100 healthy and diseased adults. Am. J. Clin. Pathol. 76:(5):1981;657-665.
29. Simpson J.G., Gray E.S., Beck J.S. Age involution in the normal human adult thymus. Clin. Exp. Immunol. 19:(2):1975;261-265.
30. Aspinall R, Andrew D. Gender related differences in the rates of age-associated thymic atrophy. Submitted.
31. Mamalaki C., Elliott J., Norton T., Yannoutsos N., Townsend A.R., Chandler P., Simpson E., Kioussis D. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev. Immunol. 3:(3):1993;159-174.
32. Tanchot C., Rocha B. The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8+ T cell pools. Eur. J. Immunol. 25:(8):1995;2127-2136.
33. Tyan M.L. Age-related decrease in mouse T cell progenitors. J. Immunol. 118:(3):1997;846-851.
34. Doria G., Mancini C., Utsuyama M., Frasca D., Hirokawa K. Aging of the recipients but not of the bone marrow donors enhances autoimmunity in syngeneic radiation chimeras. Mech. Ageing Dev. 95:(12):1997;131-142.
35. Mackall C.L., Punt J.A., Morgan P., Farr A.G., Gress R.E. Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution. Eur. J. Immunol. 28:(6):1998;1886-1893.
36. Hirokawa K., Kubo S., Utsuyama M., Kurashima C., Sado T. Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice. Cell Immunol. 100:(2):1986;443-451.
37. Yu S., Abel L., Globerson A. Thymocyte progenitors and T cell development in aging. Mech. Ageing Dev. 94:(13):1997;103-111.
38. Eren R., Zharhary D., Abel L., Globerson A. Age-related changes in the capacity of bone marrow cells to differentiate in thymic organ cultures. Cell Immunol. 112:(2):1988;449-455.
39. Sharp A., Kukulansky T., Globerson A. In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyte progenitors. Eur. J. Immunol. 20:(12):1990;2541-2546.
40. Aspinall R, Andrew D. A deficiency in Interleukin-7 is linked with age associated thymic atrophy. Submitted.
41. Hirokawa K., Utsuyama M., Kobayashi S. Hypothalamic control of development and aging of the thymus. Mech. Ageing Dev. 100:(2):1998;177-185.
42. Kelley K.W., Brief S., Westly H.J., Novakofski J., Bechtel P.J., Simon J., Walker E.B. GH3 pituitary adenoma cells can reverse thymic aging in rats. Proc. Natl. Acad. Sci. USA. 83:(15):1986;5663-5667.
43. Li Y.M., Brunke D.L., Dantzer R., Kelley K.W. Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats. Endocrinology. 130:(5):1992;2703-2709.
44. Murphy W.J., Durum S.K., Longo D.L. Differential effects of growth hormone and prolactin on murine T cell development and function. J. Exp. Med. 178:(1):1993;231-236.
45. Murphy W.J., Durum S.K., Longo D.L. Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo. J. Immunol. 149:(12):1992;3851-3857.
46. Kendall M.D., Fitzpatrick F.T., Greenstein B.D., Khoylou F., Safieh B., Hamblin A. Reversal of ageing changes in the thymus of rats by chemical or surgical castration. Cell Tissue Res. 261:(3):1990;555-564.
47. Fitzpatrick F.T., Kendall M.D., Wheeler M.J., Adcock I.M., Greenstein B.D. Reappearance of thymus of ageing rats after orchidectomy. J. Endocrinol. 106:(3):1985;R17-R19.
48. Greenstein B.D., Fitzpatrick F.T., Adcock I.M., Kendall M.D., Wheeler M.J. Reappearance of the thymus in old rats after orchidectomy: inhibition of regeneration by testosterone. J. Endocrinol. 110:(3):1986;417-422.
49. Rijhsinghani A.G., Thompson K., Bhatia S.K., Waldschmidt T.J. Estrogen blocks early T cell development in the thymus. Am. J. Reprod. Immunol. 36:(5):1996;269-277.
50. Rijhsinghani A., Bhatia S.K., Kantamneni L., Schlueter A., Waldschmidt T.J. Estrogen inhibits fetal thymocyte development in vitro. Am. J. Reprod. Immunol. 37:(5):1997;384-390.
51. Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 390:(6655):1997;45-51.
52. Alves L.A., de Carvalho A.C., Savino W. Gap junctions: a novel route for direct cell-cell communication in the immune system? Immunol. Today. 19:(6):1998;269-275.
53. Kampinga J., Berges S., Boyd R.L., Brekelmans P., Colic M., van Ewijk W., Kendall M.D., Ladyman H., Nieuwenhuis P., Ritter M.A., et al. Thymic epithelial antibodies: immunohistological analysis and introduction of nomenclature. Thymus. 13:(34):1989;165-173.
54. Farr A.G., Sidman C.L. Reduced expression of Ia antigens by thymic epithelial cells of aged mice. J. Immunol. 133:(1):1984;98-103.
55. Hartwig M., Steinmann G. On a causal mechanism of chronic thymic involution in man. Mech. Ageing Dev. 75:(2):1994;151-156.
56. Haynes B.F., Shimizu K., Eisenbarth G.S. Identification of human and rodent thymic epithelium using tetanus toxin and monoclonal antibody A2B5. J. Clin. Invest. 71:(1):1983;9-14.
57. Bhatia S.K., Tygrett L.T., Grabstein K.H., Waldschmidt T.J. The effect of in vivo IL-7 deprivation on T cell maturation. J. Exp. Med. 181:(4):1995;1399-1409.
58. von Freeden Jeffry U., Vieira P., Lucian L.A., McNeil T., Burdach S.E., Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181:(4):1995;1519-1526.
59. von Freeden Jeffry U., Solvason N., Howard M., Murray R. The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity. 7:(1):1997;147-154.
60. Takeuchi T., Kuro o, Miyazawa H., Ohtsuki Y., Yamamoto H. Transgenic expression of a novel thymic epithelial cell antigen stimulates abberant development of thymocytes. J. Immunol. 159:(2):1997;726-733.
61. Takeuchi T., Tamamoto T., Tamura H., Yamamoto H. Characterization of a 50 kDa surface membrane protein on thymic stromal cells as an important factor for early T cell development. Int. Immunol. 7:(4):1995;583-590.
62. Crompton T., Outram S.V., Buckland J., Owen M.J. A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor α chain deficient mice. Eur. J. Immunol. 27:1997;100-104.
63. Muegge K., Vila M.P., Durum S.K. Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene. Science. 261:(5117):1993;93-95.
64. Tsuda S., Rieke S., Hashimoto Y., Nakauchi H., Takahama Y. Il-7 supports D-J but not VDJ rearrangement of TCR-beta gene in fetal liver progenitor cells. J. Immunol. 156:(9):1996;3233-3242.
65. Oosterwegel M.A., Haks M.C., Jeffry U., Murray R., Kruisbeek A.M. Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class-II-expressing thymic stromal cells. Immunity. 6:(3):1997;351-360.
66. Morrissey P.J., Conlon P., Charrier K., Braddy S., Alpert A., Williams D., Namen A.E., Mochizuki D. Administration of IL-7 to normal mice stimulates B-lymphopoiesis and peripheral lymphadenopathy. J. Immunol. 147:(2):1991;561-568.
67. Morrissey P.J., Conlon P., Braddy S., Williams D.E., Namen A.E., Mochizuki D.Y. Administration of IL-7 to mice with cyclophosphamide-induced lymphopenia accelerates lymphocyte repopulation. J. Immunol. 146:(5):1991;1547-1552.
68. Bui T., Faltynek C., Ho R.J. Differential disposition of soluble and liposome-formulated human recombinant interleukin-7: effects on blood lymphocyte population in guinea pigs. Pharm. Res. 11:(5):1994;633-641.