Synthesis and evaluation of homofarnesoyl-substituted CAAX-peptidomimetics as farnesyltransferase inhibitors and antiproliferative agents

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 9, 1999, Pages 2037-2045

  Schlitzer, Martin ^a   Sattler, Isabel ^b   Dahse, Hans Martin ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Antiproliferative agents; Bisubstrate analogues; Farnesyltransferase inhibitors; Peptidomimetics; Ras

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARTIC ACID; BETA ALANINE; FARNESOL; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; TETRAPEPTIDE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CELL STRAIN HL 60; CELL STRAIN K 562; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; TUMOR CELL LINE;

ALKYL AND ARYL TRANSFERASES; ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HL-60 CELLS; HUMANS; K562 CELLS; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PEPTIDES; SPECTRUM ANALYSIS;

EID: 0032882866     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00165-0     Document Type: Article

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