X-ray crystallographic studies of Candida albicans dihydrofolate reductase: High resolution structures of the holoenzyme and an inhibited ternary complex

Journal of Biological Chemistry

Volumn 272, Issue 48, 1997, Pages 30289-30298

  Whitlow, Marc ^a,c   Howard, Andrew J ^a,d   Stewart, David ^a   Hardman, Karl D ^a,e   Kuyper, Lee F ^b   Baccanari, David P ^b   Fling, Mary E ^b   Tansik, Robert L ^b  

^a Genex Corporation   (United States)

^b GLAXOSMITHKLINE   (United States)

^c BAYER AG   (Germany)

^d Illinois Institute of Technology   (United States)

^e DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; METHOTREXATE; PYRIMETHAMINE; TRIMETHOPRIM;

ANTIFUNGAL ACTIVITY; ARTICLE; BINDING SITE; CANDIDA ALBICANS; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; ION EXCHANGE CHROMATOGRAPHY; MYCOSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING;

AMINO ACID SEQUENCE; CANDIDA ALBICANS; CRYSTALLOGRAPHY, X-RAY; FUNGAL PROTEINS; HUMANS; HYDROGEN BONDING; MOLECULAR SEQUENCE DATA; NADP; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; TETRAHYDROFOLATE DEHYDROGENASE;

BACTERIA (MICROORGANISMS); CANDIDA ALBICANS; ESCHERICHIA COLI; VERTEBRATA;

EID: 0030731508     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.48.30289     Document Type: Article

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