Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine

Anti-Cancer Drug Design

Volumn 13, Issue 4, 1998, Pages 307-315

  Cody, Vivian ^a   Galitsky, Nikolai ^a   Luft, Joseph R ^a   Pangborn, Walter ^a   Blakley, Raymond L ^b   Gangjee, Aleem ^c  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c DUQUESNE UNIVERSITY   (United States)

Author keywords

Antifolate; Antitumor; Crystal structure; Dihydrofolate reductase; Kinetic data; Variant

Indexed keywords

ANTINEOPLASTIC AGENT; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; NEW DRUG; PYRIMIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BINDING AFFINITY; DRUG BINDING; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID; FOLIC ACID ANTAGONISTS; HUMANS; METHOTREXATE; MUTATION; NADP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0031798641     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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