메뉴 건너뛰기




Volumn 50, Issue 8, 2003, Pages 324-333

Metabolic syndrome, insulin resistance and tissue metabolism;Síndrome metabólico, resistencia a la insulina y metabolismo tisular

Author keywords

Adipocyte; Insulin resistance; Liver; Metabolic syndrome; Skeletal muscle

Indexed keywords

ACTIVATED PROTEIN C; ADIPONECTIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN;

EID: 0242390554     PISSN: 15750922     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1575-0922(03)74546-X     Document Type: Review
Times cited : (14)

References (113)
  • 1
    • 0035748292 scopus 로고    scopus 로고
    • Research contributions of Eskil Kylin
    • Nilsson S. Research contributions of Eskil Kylin. Sven Med Tidskr 2001;5:15-28.
    • (2001) Sven Med Tidskr , vol.5 , pp. 15-28
    • Nilsson, S.1
  • 2
    • 0009036713 scopus 로고
    • La obesidad desde el punto de vista de su pronóstico y tratamiento
    • Marañón G, editor. Madrid: Afrosisio Aguado
    • Marañón G. La obesidad desde el punto de vista de su pronóstico y tratamiento. En: Marañón G, editor. Nuevos problemas de las secreciones internas. Madrid: Afrosisio Aguado, 1940; p. 193-231.
    • (1940) Nuevos Problemas de las Secreciones Internas , pp. 193-231
    • Marañón, G.1
  • 3
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven GM. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 4
    • 0030964387 scopus 로고    scopus 로고
    • The central role of dietary fat, not carbohydrate, in the insulin resistance syndrome
    • Purnell JQ, Brunzell JD. The central role of dietary fat, not carbohydrate, in the insulin resistance syndrome. Curr Opin Lipidol 1997;8:17-22.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 17-22
    • Purnell, J.Q.1    Brunzell, J.D.2
  • 5
    • 0027183606 scopus 로고
    • Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles
    • Reaven GM, Chen YD, Jeppesen J, Maheux P, Krauss RM. Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles. J Clin Invest 1993;92:141-46.
    • (1993) J Clin Invest , vol.92 , pp. 141-146
    • Reaven, G.M.1    Chen, Y.D.2    Jeppesen, J.3    Maheux, P.4    Krauss, R.M.5
  • 6
    • 0029037649 scopus 로고
    • Pathophysiology of insulin resistance in human disease
    • Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev 1995;75:473-86.
    • (1995) Physiol Rev , vol.75 , pp. 473-486
    • Reaven, G.M.1
  • 7
    • 0030933761 scopus 로고    scopus 로고
    • Do high carbohydrate diets prevent the development or attenuate the manifestations or both of syndrome X? A viewpoint strongly against
    • Reaven GM. Do high carbohydrate diets prevent the development or attenuate the manifestations or both of syndrome X? A viewpoint strongly against. Curr Opin Lipidol 1997;8:23-7.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 23-27
    • Reaven, G.M.1
  • 8
    • 0036177867 scopus 로고    scopus 로고
    • Control of energy homeostasis and insulin action by adipocyte hormones: Leptin, acylation stimulating protein and adiponectin
    • Havel PJ. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein and adiponectin. Curr Opin Lipidol 2002;13:51-9.
    • (2002) Curr Opin Lipidol , vol.13 , pp. 51-59
    • Havel, P.J.1
  • 9
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications, part 1: Diagnosis and classification of diabetes mellitus Provisional report of a WHO consultation
    • Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications, part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabetes Med 1998;15:539-53.
    • (1998) Diabetes Med , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 10
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP)
    • Expert Panel on Detection, Evaluation, and Treatment of High Cholesterol In Adults Human (Adult Treatment Panel III)
    • Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP). Expert Panel on Detection, Evaluation, and Treatment of High Cholesterol In Adults Human (Adult Treatment Panel III). JAMA 2001;285:2486-97.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 11
    • 0042140706 scopus 로고    scopus 로고
    • Consenso SEEDO'2000 para la evaluación del sobrepeso y la obesidad y el establecimiento de criterios de intervención terapéutica
    • Consenso SEEDO'2000 para la evaluación del sobrepeso y la obesidad y el establecimiento de criterios de intervención terapéutica. Med Clin 2000:15:587-98.
    • (2000) Med Clin , vol.15 , pp. 587-598
  • 12
    • 0021152686 scopus 로고
    • Abdominal adipose tissue distribution obesity and of cardiovascular disease and death: 13 Year follow-up of participants in the study of men born in 1913
    • Larsson B, Suarsudd K, Welin L, Wilheumsen L, Bjortorp BP, Tibblin G, et al. Abdominal adipose tissue distribution obesity and of cardiovascular disease and death: 13 year follow-up of participants in the study of men born in 1913. Br Med J 1984;288:1401-4.
    • (1984) Br Med J , vol.288 , pp. 1401-1404
    • Larsson, B.1    Suarsudd, K.2    Welin, L.3    Wilheumsen, L.4    Bjortorp, B.P.5    Tibblin, G.6
  • 13
    • 0034528023 scopus 로고    scopus 로고
    • Risk factors associated with obesity: A metabolic perspective
    • Despres JP, Pascot A, Lemieux J. Risk factors associated with obesity: a metabolic perspective. Ann Endocrinol 2000;6:31-8.
    • (2000) Ann Endocrinol , vol.6 , pp. 31-38
    • Despres, J.P.1    Pascot, A.2    Lemieux, J.3
  • 14
    • 0036770237 scopus 로고    scopus 로고
    • Interrelationship between serum lipid profile, serum hormones and other components of the metabolic syndrome
    • Garaulet M, Pérez-Llamas F, Zamora S, Tebar FJ. Interrelationship between serum lipid profile, serum hormones and other components of the metabolic syndrome. J Physiol Biochem 2002;58:151-60.
    • (2002) J Physiol Biochem , vol.58 , pp. 151-160
    • Garaulet, M.1    Pérez-Llamas, F.2    Zamora, S.3    Tebar, F.J.4
  • 16
  • 17
    • 85030940009 scopus 로고    scopus 로고
    • El síndrome metabólico en su 80 aniversario
    • Actas 2.° Simposio científico. Madrid
    • Serrano Ríos M. The Metabolic Syndrome in Spain. El síndrome metabólico en su 80 aniversario. Actas 2.° Simposio científico. Madrid, 2002.
    • (2002) The Metabolic Syndrome in Spain
    • Serrano Ríos, M.1
  • 18
    • 0037069149 scopus 로고    scopus 로고
    • Resistencia a la insulina y su implicación en múltiples factores de riesgo asociados a diabetes tipo 2
    • Grupo de Trabajo Resistencia a la insulina de la Sociedad Española de Diabetes tipo 2. Resistencia a la insulina y su implicación en múltiples factores de riesgo asociados a diabetes tipo 2. Med Clin (Barc) 2002;119:458-63.
    • (2002) Med Clin (Barc) , vol.119 , pp. 458-463
  • 19
    • 50249216083 scopus 로고
    • Diabetes mellitus: Its differentiation into insulin-sensitive and insulin-insensitive types
    • Himswort HP. Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types. Lancet 1936;1:127-34.
    • (1936) Lancet , vol.1 , pp. 127-134
    • Himswort, H.P.1
  • 20
    • 0000502560 scopus 로고
    • Forearm metabolism in obesity and its response to intra-arterial insulin. Evidence for adaptive hyperinsulinismus
    • Rabinowitz D, Zierler KL. Forearm metabolism in obesity and its response to intra-arterial insulin. Evidence for adaptive hyperinsulinismus. Lancet 1961;2:690-2.
    • (1961) Lancet , vol.2 , pp. 690-692
    • Rabinowitz, D.1    Zierler, K.L.2
  • 21
    • 0023816690 scopus 로고
    • Role of insulin in regulation of lipoprotein metabolism in diabetes
    • Reaven GH, Chen YDI. Role of insulin in regulation of lipoprotein metabolism in diabetes. Diab Metabol Rev 1988;4:639-52.
    • (1988) Diab Metabol Rev , vol.4 , pp. 639-652
    • Reaven, G.H.1    Chen, Y.D.I.2
  • 22
    • 0026021161 scopus 로고    scopus 로고
    • Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease
    • 199
    • De Fronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care 199;14:173-94.
    • Diabetes Care , vol.14 , pp. 173-194
    • De Fronzo, R.A.1    Ferrannini, E.2
  • 24
    • 0036203254 scopus 로고    scopus 로고
    • Concentrations of proinsulin like molecules predict coronary heart disease risk independently of insulin: Prospective data from the Caerphilly Study
    • Yudkin JS, May M, Elwood P, Yarnell JWG, Greenwood R, Davey Smith. Concentrations of proinsulin like molecules predict coronary heart disease risk independently of insulin: prospective data from the Caerphilly Study. Diabetologia 2002;45:327-36.
    • (2002) Diabetologia , vol.45 , pp. 327-336
    • Yudkin, J.S.1    May, M.2    Elwood, P.3    Yarnell, J.W.G.4    Greenwood, R.5    Smith, D.6
  • 25
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • De Fronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:214-23.
    • (1979) Am J Physiol , vol.237 , pp. 214-223
    • De Fronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 28
    • 0024600102 scopus 로고
    • Estimates in vivo insulin action in man: Comparation of insulin tolerance test with euglycemic and hyperglicemic glucose clamp studies
    • Bonora E, Moghetti P, Zancanaro C, Cigolini M, Querena M, Cacciarori V, et al. Estimates in vivo insulin action in man: comparation of insulin tolerance test with euglycemic and hyperglicemic glucose clamp studies. J Clin Endocrinol Metab 1989;68:374-8.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 374-378
    • Bonora, E.1    Moghetti, P.2    Zancanaro, C.3    Cigolini, M.4    Querena, M.5    Cacciarori, V.6
  • 29
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and B cell function from fatting plasma and insulin concentration in man
    • Matthews DR, Hossker JP, Rudenski AS, Naylor BA, Teacher DF, Turner RC. Homeostasis model assessment: insulin resistance and B cell function from fatting plasma and insulin concentration in man. Diabetologia 1985;28:412-49.
    • (1985) Diabetologia , vol.28 , pp. 412-449
    • Matthews, D.R.1    Hossker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Teacher, D.F.5    Turner, R.C.6
  • 30
    • 0021812194 scopus 로고
    • Continuous infusion of glucose with model assessment: Measurement in insulin resistance and β-cell function in man
    • Hosker JP, Matthews DR, Rudenski AS, Bumett MA, Darling P, Brorwn EG, et al. Continuous infusion of glucose with model assessment: measurement in insulin resistance and β-cell function in man. Diabetologia 1985;28:401-11.
    • (1985) Diabetologia , vol.28 , pp. 401-411
    • Hosker, J.P.1    Matthews, D.R.2    Rudenski, A.S.3    Bumett, M.A.4    Darling, P.5    Brorwn, E.G.6
  • 31
    • 0035346464 scopus 로고    scopus 로고
    • Nuevo panorama para el entendimiento de los vínculos moleculares entre la obesidad y la diabetes tipo 2
    • Fernández-Mejía C. Nuevo panorama para el entendimiento de los vínculos moleculares entre la obesidad y la diabetes tipo 2. Rev Invest Clin 2001;53:209-11.
    • (2001) Rev Invest Clin , vol.53 , pp. 209-211
    • Fernández-Mejía, C.1
  • 32
    • 0036257035 scopus 로고    scopus 로고
    • El tejido adiposo: Órgano de almacenamiento y órgano secretor
    • Moreno MJ, Martínez JA. El tejido adiposo: órgano de almacenamiento y órgano secretor. Anales Del Sist San Nav 2002:25:29-39.
    • (2002) Anales del Sist San Nav , vol.25 , pp. 29-39
    • Moreno, M.J.1    Martínez, J.A.2
  • 33
    • 0031181718 scopus 로고    scopus 로고
    • The acylation - Stimulating protein pathway and regulation of postprandial metabolism
    • Sniderman AD, Cianflone K, Summers LKM, Fielding BA, Frayn KN. The acylation - stimulating protein pathway and regulation of postprandial metabolism. Nutr Soc 1997;56:703-12.
    • (1997) Nutr Soc , vol.56 , pp. 703-712
    • Sniderman, A.D.1    Cianflone, K.2    Summers, L.K.M.3    Fielding, B.A.4    Frayn, K.N.5
  • 34
    • 0024390731 scopus 로고
    • Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue
    • Ong JM, Kern PA. Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue. Clin Inves 1989;84:305-11.
    • (1989) Clin Inves , vol.84 , pp. 305-311
    • Ong, J.M.1    Kern, P.A.2
  • 36
    • 0035905772 scopus 로고    scopus 로고
    • Diabetes: The missing link with obesity?
    • Flier JS. Diabetes: The missing link with obesity? Nature 2001;409:292-3.
    • (2001) Nature , vol.409 , pp. 292-293
    • Flier, J.S.1
  • 38
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden G, Chen X, Ruiz J, White JV y Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 1994;93:2438-46.
    • (1994) J Clin Invest , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 39
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 1995;44:863-70.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 40
    • 0034090489 scopus 로고    scopus 로고
    • Fatty acids and insulin secretion
    • Grill V, Qvigstad E. Fatty acids and insulin secretion. Br J Nutr 2000;83:79-84.
    • (2000) Br J Nutr , vol.83 , pp. 79-84
    • Grill, V.1    Qvigstad, E.2
  • 41
    • 0022369998 scopus 로고
    • Tumor necrosis factor (TNF)
    • Old LJ. Tumor necrosis factor (TNF). Science 1985;230:630-32.
    • (1985) Science , vol.230 , pp. 630-632
    • Old, L.J.1
  • 42
    • 0034728722 scopus 로고    scopus 로고
    • Papel del factor de necrosis tumoral en el control de las reservas grasas y la obesidad
    • Bulló Bonet M, García-Lord P, Argilés JM, Salas-Salvadó J. Papel del factor de necrosis tumoral en el control de las reservas grasas y la obesidad. Med Clin (Barc) 2000;114:624-30.
    • (2000) Med Clin (Barc) , vol.114 , pp. 624-630
    • Bulló Bonet, M.1    García-Lord, P.2    Argilés, J.M.3    Salas-Salvadó, J.4
  • 43
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue: Regulation by obesity, weight loss: And relationship to lipoprotein lipase
    • Kern PA, Saghidazdeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue: regulation by obesity, weight loss: and relationship to lipoprotein lipase. J Clin Invest 1995;95:2111-19.
    • (1995) J Clin Invest , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghidazdeh, M.2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5    Simsolo, R.B.6
  • 44
    • 0030028606 scopus 로고    scopus 로고
    • The expression of TNF-α by human muscle: Relationship to insulin resistance
    • Saghidazdeh M, Ong J. M, Garvey WT, Henry RR, Kern PA. The expression of TNF-α by human muscle: relationship to insulin resistance. J Clin Invest 1996;97:1111-16.
    • (1996) J Clin Invest , vol.97 , pp. 1111-1116
    • Saghidazdeh, M.1    Ong, J.M.2    Garvey, W.T.3    Henry, R.R.4    Kern, P.A.5
  • 45
    • 0028587742 scopus 로고
    • Tumor necrosis factor alpha: A key component of the obesity-diabetes link
    • Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 1994;43:1271-8.
    • (1994) Diabetes , vol.43 , pp. 1271-1278
    • Hotamisligil, G.S.1    Spiegelman, B.M.2
  • 46
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF and obesity induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF and obesity induced insulin resistance. Science 1996;271:665-8.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 47
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-TNF a antibody (CDPS71) on insulin sensitivity and glycemic control in patients with NIDDM
    • Ofei F, Hurel S, Newkirk J, Sopwith M, Taylor R. Effects of an engineered human anti-TNF a antibody (CDPS71) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 1996;45:881-5.
    • (1996) Diabetes , vol.45 , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 49
    • 0006597145 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue expression of tumor necrosis factor-alpha is not associated with whole body insulin resistance in obese nondiabetic or in type-2 diabetic subjects
    • Koistinen HA, Bastard JP, Dusserre E, Ebeling P, Zegari N, Vidal H, et al. Subcutaneous adipose tissue expression of tumor necrosis factor-alpha is not associated with whole body insulin resistance in obese nondiabetic or in type-2 diabetic subjects. Eur J Clin Invest 2000;30:302-10.
    • (2000) Eur J Clin Invest , vol.30 , pp. 302-310
    • Koistinen, H.A.1    Bastard, J.P.2    Dusserre, E.3    Ebeling, P.4    Zegari, N.5    Vidal, H.6
  • 50
    • 0033613545 scopus 로고    scopus 로고
    • Novel modulator for endothelial adhesion molecular. Adipocyte-derived plasma protein adiponectin
    • Ouchi N, Aichaud G, Negrel R. Novel modulator for endothelial adhesion molecular. Adipocyte-derived plasma protein adiponectin. Circulation 1999;100:2473-76.
    • (1999) Circulation , vol.100 , pp. 2473-2476
    • Ouchi, N.1    Aichaud, G.2    Negrel, R.3
  • 53
    • 0034999667 scopus 로고    scopus 로고
    • Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
    • Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Tataranni PA. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin. Endocrinol Metab 2001;86:1930-5.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1930-1935
    • Weyer, C.1    Funahashi, T.2    Tanaka, S.3    Hotta, K.4    Matsuzawa, Y.5    Tataranni, P.A.6
  • 54
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-6.
    • (2001) Nat Med , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3    Terauchi, Y.4    Kubota, N.5    Kadowaki, T.6
  • 55
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001;7:947-53.
    • (2001) Nat Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 56
    • 0035462629 scopus 로고    scopus 로고
    • PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    • Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Matsuzawa Y. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001;50:2094-9.
    • (2001) Diabetes , vol.50 , pp. 2094-2099
    • Maeda, N.1    Takahashi, M.2    Funahashi, T.3    Kihara, S.4    Nishizawa, H.5    Matsuzawa, Y.6
  • 57
    • 0036511213 scopus 로고    scopus 로고
    • ACRP30/adiponectin: An adipokine regulating glucose and lipid metabolism
    • Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002;13:84-9.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 84-89
    • Berg, A.H.1    Combs, T.P.2    Scherer, P.E.3
  • 59
    • 0036090282 scopus 로고    scopus 로고
    • Increased resistin gene and protein expression in human abdominal adipose tissue
    • Mcternan PG. Increased resistin gene and protein expression in human abdominal adipose tissue. J.Clin Endocrinol Metab 2002;87:2407-10.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2407-2410
    • Mcternan, P.G.1
  • 61
    • 0242641149 scopus 로고    scopus 로고
    • Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisoma proliferator - Activated receptor gamma agonists
    • Way J M, Gorgun CZ, Tong Q, Uysal K, Brown KK, Harrington WW, et al. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisoma proliferator - activated receptor gamma agonists. J Biol Chem 2001;276:25651-3.
    • (2001) J Biol Chem , vol.276 , pp. 25651-25653
    • Way, J.M.1    Gorgun, C.Z.2    Tong, Q.3    Uysal, K.4    Brown, K.K.5    Harrington, W.W.6
  • 63
    • 0033586747 scopus 로고    scopus 로고
    • The role of leptin in human obesity and disease. A review of current evidence
    • Mantzoros C. The role of leptin in human obesity and disease. A review of current evidence. Ann Intern Med 1999;130:671-80.
    • (1999) Ann Intern Med , vol.130 , pp. 671-680
    • Mantzoros, C.1
  • 64
    • 0033023268 scopus 로고    scopus 로고
    • Regulation and possible significance of leptin in humans: Leptin in health and disease
    • Dagogo-Jack S. Regulation and possible significance of leptin in humans: leptin in health and disease. Diabetes Rev 1999;7:23-37.
    • (1999) Diabetes Rev , vol.7 , pp. 23-37
    • Dagogo-Jack, S.1
  • 65
    • 0033794850 scopus 로고    scopus 로고
    • Human leptin: From an adipocyte hormone to an endocrine mediator
    • Wauters M, Considine M, Van Gaal L. Human leptin: from an adipocyte hormone to an endocrine mediator. Eur J Endocrinol 2000;143:293-311.
    • (2000) Eur J Endocrinol , vol.143 , pp. 293-311
    • Wauters, M.1    Considine, M.2    Van Gaal, L.3
  • 66
    • 0007524724 scopus 로고    scopus 로고
    • Evidence of free and bound leptin in human circulation: Studies in lean and obese subjects and during short term fasting
    • Sinha MK, Opentanova I, Ohannesian JP, Kolaazynsiki JW, Heiman ML, Cano JF. Evidence of free and bound leptin in human circulation: studies in lean and obese subjects and during short term fasting. J Clin Invest 1996;98:1277-82.
    • (1996) J Clin Invest , vol.98 , pp. 1277-1282
    • Sinha, M.K.1    Opentanova, I.2    Ohannesian, J.P.3    Kolaazynsiki, J.W.4    Heiman, M.L.5    Cano, J.F.6
  • 68
    • 0036790412 scopus 로고    scopus 로고
    • Peripheral actions of leptin and its involvement in disease
    • Fruhbeck G. Peripheral actions of leptin and its involvement in disease. Nutr Rev 2002;60:47-55.
    • (2002) Nutr Rev , vol.60 , pp. 47-55
    • Fruhbeck, G.1
  • 69
    • 0033037107 scopus 로고    scopus 로고
    • Leptin and its potential role in human obesity
    • Lonqvist F, Nordfors L, Schalling M. Leptin and its potential role in human obesity. J Intern Med 1999;245:643-52.
    • (1999) J Intern Med , vol.245 , pp. 643-652
    • Lonqvist, F.1    Nordfors, L.2    Schalling, M.3
  • 70
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and regulation of body weight in mammals
    • Friedman J, Halaas J. Leptin and regulation of body weight in mammals. Nature 1998;395:763-9.
    • (1998) Nature , vol.395 , pp. 763-769
    • Friedman, J.1    Halaas, J.2
  • 71
    • 0036328381 scopus 로고    scopus 로고
    • Analysis of paradoxical observations on the association between leptin and insulin resistance
    • Ceddia RB, Koistinen HA, Zierath JR, Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J 2002;16:1163-76.
    • (2002) FASEB J , vol.16 , pp. 1163-1176
    • Ceddia, R.B.1    Koistinen, H.A.2    Zierath, J.R.3    Sweeney, G.4
  • 72
    • 0033218066 scopus 로고    scopus 로고
    • Cardiopatía isquémica: Marcadores de inflamación y riesgo cardiovascular
    • García-Moll X, Kaski JC. Cardiopatía isquémica: marcadores de inflamación y riesgo cardiovascular. Rev Esp Cardiol 1999;52:990-1003.
    • (1999) Rev Esp Cardiol , vol.52 , pp. 990-1003
    • García-Moll, X.1    Kaski, J.C.2
  • 73
    • 0024362092 scopus 로고
    • C-reactive protein. A historical overwiew
    • Gotschlich EC. C-reactive protein. A historical overwiew. Ann N Y Acad Sci 1989;557:9-18.
    • (1989) Ann N Y Acad Sci , vol.557 , pp. 9-18
    • Gotschlich, E.C.1
  • 74
    • 0034604248 scopus 로고    scopus 로고
    • Chronic subclinical inflammation as part of the Insulin Resistance Atherosclerosis Study (IRAS)
    • Festa A, D'Agostino R, Howard G, Mykkanen L, Russell PT, Haffner S. Chronic subclinical inflammation as part of the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000;102:42.
    • (2000) Circulation , vol.102 , pp. 42
    • Festa, A.1    D'Agostino, R.2    Howard, G.3    Mykkanen, L.4    Russell, P.T.5    Haffner, S.6
  • 75
    • 0034769085 scopus 로고    scopus 로고
    • C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women
    • Pannacciulli N, Cantatore FP, Minenna A, Bellacicco M, Giorgino R, De Pergola G. C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women. Int J Obes 2001;2:1416-20.
    • (2001) Int J Obes , vol.2 , pp. 1416-1420
    • Pannacciulli, N.1    Cantatore, F.P.2    Minenna, A.3    Bellacicco, M.4    Giorgino, R.5    De Pergola, G.6
  • 76
    • 0037078969 scopus 로고    scopus 로고
    • Comparison of C-Reactive Protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
    • Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-Reactive Protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002;347:1557-65.
    • (2002) N Engl J Med , vol.347 , pp. 1557-1565
    • Ridker, P.M.1    Rifai, N.2    Rose, L.3    Buring, J.E.4    Cook, N.R.5
  • 77
    • 0037469232 scopus 로고    scopus 로고
    • Markers of inflammation and cardiovascular disease
    • Person TA, Mensah GA. Markers of inflammation and cardiovascular disease. Circulation 2003;107:499-511.
    • (2003) Circulation , vol.107 , pp. 499-511
    • Person, T.A.1    Mensah, G.A.2
  • 78
    • 0021053614 scopus 로고
    • Evidence for the occurrence of a fast acting inhibitor for tissue type plasminogen activator in plasma
    • Chmielewska J, Ranby M, Wiman B. Evidence for the occurrence of a fast acting inhibitor for tissue type plasminogen activator in plasma. Thromb Res 1983;31:427-36.
    • (1983) Thromb Res , vol.31 , pp. 427-436
    • Chmielewska, J.1    Ranby, M.2    Wiman, B.3
  • 79
    • 15844381594 scopus 로고    scopus 로고
    • Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity
    • Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, et al. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996;2:800-3.
    • (1996) Nat Med , vol.2 , pp. 800-803
    • Shimomura, I.1    Funahashi, T.2    Takahashi, M.3    Maeda, K.4    Kotani, K.5    Nakamura, T.6
  • 80
    • 0030975615 scopus 로고    scopus 로고
    • Production of plasminogen activator inhibitor 1 by human adipose tissue: Possible link between visceral fat accumulation and vascular disease
    • Alessi MC, Peiretti F, Morange P, Henry M, Nalbone G, Juhan-Vague I. Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease. Diabetes 1997;46:860-7.
    • (1997) Diabetes , vol.46 , pp. 860-867
    • Alessi, M.C.1    Peiretti, F.2    Morange, P.3    Henry, M.4    Nalbone, G.5    Juhan-Vague, I.6
  • 82
    • 0343893674 scopus 로고    scopus 로고
    • Relationship between plasma plasminogen activator inhibitor 1 and insulin resistance
    • Bastard JP, Pieroni L, Hainque B. Relationship between plasma plasminogen activator inhibitor 1 and insulin resistance. Diab Metab Rev 2000;16:192-201.
    • (2000) Diab Metab Rev , vol.16 , pp. 192-201
    • Bastard, J.P.1    Pieroni, L.2    Hainque, B.3
  • 83
    • 85030936262 scopus 로고    scopus 로고
    • Reducción del potencial fibrinolítico relacionado con aumento de la expresión de PAI-1 vascular en injertos aorto-coronarios
    • Orbe J, Martin Trenor A, Rábago G, Belzunce M, Roncal C, Páramo JA. Reducción del potencial fibrinolítico relacionado con aumento de la expresión de PAI-1 vascular en injertos aorto-coronarios. Haematologica (ed. esp.) 2000;85:136.
    • (2000) Haematologica (Ed. Esp.) , vol.85 , pp. 136
    • Orbe, J.1    Martin Trenor, A.2    Rábago, G.3    Belzunce, M.4    Roncal, C.5    Páramo, J.A.6
  • 84
    • 0037469261 scopus 로고    scopus 로고
    • C-reactive Protein Increases Plasminogen Activator Inhibitor-1 expression and Activity in Human Aortic Endothelial Cells. Implications for the Metabolic Syndrome and Atherothombosis
    • Sridevi Devaraj, Dan Yan Xu, Ishwarlala Jialal. C-reactive Protein Increases Plasminogen Activator Inhibitor-1 expression and Activity in Human Aortic Endothelial Cells. Implications for the Metabolic Syndrome and Atherothombosis. Circulation 2003;107:1-7.
    • (2003) Circulation , vol.107 , pp. 1-7
    • Devaraj, S.1    Xu, D.Y.2    Jialal, I.3
  • 87
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steathepatitis) and obesity: An autopsy study with analysis of risk factors
    • Wanless IR, Lentz JS. Fatty liver hepatitis (steathepatitis) and obesity: An autopsy study with analysis of risk factors. Hepatology 1990;12:1106-10.
    • (1990) Hepatology , vol.12 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 88
    • 0026021161 scopus 로고    scopus 로고
    • Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hipertension, dyslipidemia and atherosclerotic cardiovascular disease
    • De Fronzo RA, Ferranini. Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hipertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care 1991;14:173-94.
    • (1991) Diabetes Care , vol.14 , pp. 173-194
    • De Fronzo, R.A.1    Ferranini2
  • 91
    • 18244385511 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis, insulin resistance and metabolic syndrome: Further evidence for an etiologic association
    • Pagano G, Pacini G, Musso G, Gambino R, Mecca F, Depretis N, et al. Non-alcoholic steatohepatitis, insulin resistance and metabolic syndrome: Further evidence for an etiologic association. Hepatology 2002;35:367-72.
    • (2002) Hepatology , vol.35 , pp. 367-372
    • Pagano, G.1    Pacini, G.2    Musso, G.3    Gambino, R.4    Mecca, F.5    Depretis, N.6
  • 92
    • 18244364864 scopus 로고    scopus 로고
    • Nash and insulin resistance: Insulin hypersecretion and specific association with insulin resistance syndrome
    • Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C, et al. Nash and insulin resistance: Insulin hypersecretion and specific association with insulin resistance syndrome. Hepatology 2002;35:373-9.
    • (2002) Hepatology , vol.35 , pp. 373-379
    • Chitturi, S.1    Abeygunasekera, S.2    Farrell, G.C.3    Holmes-Walker, J.4    Hui, J.M.5    Fung, C.6
  • 96
    • 0031706536 scopus 로고    scopus 로고
    • Relationship between impaired glucose tolerance, non insulin-dependent diabetes mellitus and obesity
    • Ferrannini E, Camastra S. Relationship between impaired glucose tolerance, non insulin-dependent diabetes mellitus and obesity. Eur J Clin Invest 1998;28:3-6.
    • (1998) Eur J Clin Invest , vol.28 , pp. 3-6
    • Ferrannini, E.1    Camastra, S.2
  • 97
    • 0033929769 scopus 로고    scopus 로고
    • Relationship between regional fat distribution and insulin resistance
    • Bonora E. Relationship between regional fat distribution and insulin resistance. Int Obes 2000;24:32-5.
    • (2000) Int Obes , vol.24 , pp. 32-35
    • Bonora, E.1
  • 99
    • 0024639485 scopus 로고
    • Subcapsular steatonecrosis in response to peritoneal insulin delivery: A clue to the pathogenesis of steatonecrosis in obesity
    • Wanless IR, Bergman JM, Oreopoulas DG, Vas SI. Subcapsular steatonecrosis in response to peritoneal insulin delivery: a clue to the pathogenesis of steatonecrosis in obesity. Mod Pathol 1989;2:69-74.
    • (1989) Mod Pathol , vol.2 , pp. 69-74
    • Wanless, I.R.1    Bergman, J.M.2    Oreopoulas, D.G.3    Vas, S.I.4
  • 100
    • 0035141841 scopus 로고    scopus 로고
    • Unusual patterns of hepatic steatosis caused by the local effect of insulin revealed on chemical shift MR imaging
    • Sohn J, Siegelman E, Osiason A. Unusual patterns of hepatic steatosis caused by the local effect of insulin revealed on chemical shift MR imaging. Am J Roentgenol 2001;176:471-4.
    • (2001) Am J Roentgenol , vol.176 , pp. 471-474
    • Sohn, J.1    Siegelman, E.2    Osiason, A.3
  • 102
    • 0024336332 scopus 로고
    • Nonalcoholic steatohepatitis: A study of 39 patients
    • Lee RG. Nonalcoholic steatohepatitis: A study of 39 patients. Hum Pathol 1989;20:594-8.
    • (1989) Hum Pathol , vol.20 , pp. 594-598
    • Lee, R.G.1
  • 103
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years. Hepatology 1990;11:74-80.
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 106
    • 0032612742 scopus 로고    scopus 로고
    • Obesity, insulin resistance and skeletal muscle characteristics
    • Torres SH. Obesity, insulin resistance and skeletal muscle characteristics. Acta Cient Venez 1999;50:34-41.
    • (1999) Acta Cient Venez , vol.50 , pp. 34-41
    • Torres, S.H.1
  • 107
    • 0033595121 scopus 로고    scopus 로고
    • Glucose transporters and insulin action. Implications for insulin resistance and diabetes mellitus
    • Sherpherd P, Kahn B. Glucose transporters and insulin action. Implications for insulin resistance and diabetes mellitus. New Engl J Med 1999;341:248-57.
    • (1999) New Engl J Med , vol.341 , pp. 248-257
    • Sherpherd, P.1    Kahn, B.2
  • 108
    • 0032452225 scopus 로고    scopus 로고
    • Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years
    • Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diab Metabol Rev 1998;14:263-83.
    • (1998) Diab Metabol Rev , vol.14 , pp. 263-283
    • Randle, P.J.1
  • 109
    • 0031882141 scopus 로고    scopus 로고
    • Metabolic interactions between glucose and fatty acids in human
    • Wolfe R. Metabolic interactions between glucose and fatty acids in human. Am J Clin Nutr 1998;67:519-26.
    • (1998) Am J Clin Nutr , vol.67 , pp. 519-526
    • Wolfe, R.1
  • 111
    • 0036296672 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride. An aspect of regional adipocity and insulin resistance
    • Kelley DE. Skeletal muscle triglyceride. An aspect of regional adipocity and insulin resistance. Ann N Y Acad Sci 2002;967:135-45.
    • (2002) Ann N Y Acad Sci , vol.967 , pp. 135-145
    • Kelley, D.E.1
  • 112
    • 0036294862 scopus 로고    scopus 로고
    • Relationship between insulin resistance and muscle triglyceride content in non-obese experimental models of insulin resistance syndrome
    • Divisova J, Kazdova L, Hudova M, Meschisvili E. Relationship between insulin resistance and muscle triglyceride content in non-obese experimental models of insulin resistance syndrome. Ann N Y Acad Sci 2002;967:440-5.
    • (2002) Ann N Y Acad Sci , vol.967 , pp. 440-445
    • Divisova, J.1    Kazdova, L.2    Hudova, M.3    Meschisvili, E.4
  • 113
    • 0035345532 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride: An aspect of regional adiposity and insulin resistance
    • Kelley DE, Goodpaster BH. Skeletal muscle triglyceride: an aspect of regional adiposity and insulin resistance. Diabetes Care 2001;24:933-41.
    • (2001) Diabetes Care , vol.24 , pp. 933-941
    • Kelley, D.E.1    Goodpaster, B.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.