Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′-deoxycytidine

International Journal of Radiation Oncology Biology Physics

Volumn 34, Issue 4, 1996, Pages 867-872

  Lawrence, Theodore S ^a   Chang, Emily Y ^a   Hahn, Tina M ^a   Hertel, Larry W ^b   Shewach, Donna S ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Deoxynucleotides; Gemcitabine; Pancreatic cancer; Radiosensitizers

Indexed keywords

DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE; GEMCITABINE;

ARTICLE; CELL CYCLE; COLON CANCER; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; HUMAN TISSUE; PANCREAS CANCER; PRIORITY JOURNAL; PROGNOSIS; RADIOSENSITIVITY; RADIOSENSITIZATION;

ADENOSINE TRIPHOSPHATE; CELL CYCLE; CELL SURVIVAL; CYTIDINE TRIPHOSPHATE; DEOXYCYTIDINE; DRUG SCREENING ASSAYS, ANTITUMOR; GUANOSINE TRIPHOSPHATE; HUMANS; PANCREATIC NEOPLASMS; RADIATION-SENSITIZING AGENTS; THYMINE NUCLEOTIDES; TUMOR CELLS, CULTURED;

EID: 0030005273     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/0360-3016(95)02134-5     Document Type: Article

References (27)

1. Abbruzzese, J. L.; Grunewald, R.; Weeks, E. A.; Gravel, D.; Adams, T.; Nowak, B.; Mineishi, S.; Tarassoff, P.; Satterlee, W.; Raber, M. N.; Plunkett, W. P. A. A phase I clinical, plasma, and cellular pharmacology study of gemcitabine. J. Clin. Oncol. 9:491-498; 1991.
2. Baker, C. H.; Banzon, J.; Bollinger, J. M.; Stubbe, J; Samano, V.; Robins, M. J.; Lippert, B.; Jarvi, E.; Resvick, R. 2′-Deoxy-2′-methylenecytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphates: Potent mechanism-based inhibitors of ribonucleotide reductase. J. Med. Chem. 34:1879-1884; 1991.
3. Bruso, C. E.; Shewach, D. S.; Lawrence, T. S. Fluorodeoxy-uridine-induced radiosensitization and inhibition of DNA double strand break repair in human colon cancer cells. Int. J. Radiat. Oncol. Biol. Phys. 19:1411-1417; 1990.
4. Fertil, B.; Dertinger, H.; Courdi, A.; Malaise, E. P. Mean inactivation dose: A useful concept for intercomparison of human cell survival curves. Radiat. Res. 99:73-84; 1984.
5. Gandhi, V.; Plunkett, W. Modulatory activity of 2′,2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides. Cancer Res. 50:3675-3680; 1990.
6. Heimburger, D. K.; Shewach, D. S.; Lawrence, T. S. The effect of fluorodeoxyuridine on sublethal damage repair in human colon cancer cells. Int. J. Radiat. Oncol. Biol. Phys. 21:983-987; 1991.
7. Heinemann, V.; Xu, Y. Z.; Chubb, S.; Sen, A.; Hertel, L. W.; Grindey, G. B.; Plunkett, W. Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine. Mol. Pharmacol. 38:567-572; 1990.
8. Iliakis, G.; Kurtzman, S.; Pantelias, G.; Okayasu, R. Mechanism of radiosensitization by halogenated pyrimidines: Effect of BrdU on radiation induction of DNA and chromosome damage and its correlation with cell killing. Radiat. Res. 119:286-304; 1989.
9. Kaye, S. B. Gemcitabine: Current status of phase I and II trials (a review). J. Clin. Oncol. 12:1527-1531; 1994.
10. Kinsella, T. J.; Dobson, P. A.; Mitchell, J. B.; Fornace, A. J. Enchancement of X-ray induced DNA damage by pretreatment with halogenated pyrimidine analogs. Int. J. Radiat. Oncol. Biol. Phys. 13:733-739; 1987.
11. Lawrence, T. S.; Davis, M. A.; Maybaum, J.; Stetson, P. L.; Ensminger, W. D. The effect of single vs. double-strand substitution on halogenated pyrimidine-induced radiosensitization and DNA strand breakage in human tumor cells. Radiat. Res. 123:192-198; 1990.
12. Ling, L. L.; Ward, J. F. Radiosensitization of Chinese hamster V79 cells by bromodeoxyuridine substitution of thymidine: enhancement of radiation-induced toxicity and DNA strand break production by monofilar and bifilar substitution. Radiat. Res. 121:76-83; 1990.
13. Lund, B.; Kristjansen, P. E.; Hansen, H. H. Clinical and preclinical activity of 2′,2′-difluorodeoxycytidine (gemcitabine). Cancer Treat. Rev. 19:45-55; 1993.
14. McGinn, C. J.; Miller, E. M.; Lindstrom, M. J.; Kunugi, K. A.; Kinsella, T. J. The role of cell cycle redistribution in radiosensitization: Implications regarding the mechanism of fluorodeoxyuridine radiosensitization. Int. J. Radiat. Oncol. Biol. Phys. 30:851-859, 1994.
15. Miller, E. M.; Kinsella, T. J. Radiosensitization by fluorodeoxyuridine: Effects of thymidylate synthase inhibition and cell synchronization. Cancer Res. 52:1687-1694; 1992.
16. Moertel, C. G.; Frytak, S.; Hahn, R. G.; O'Connell, M. J.; Reitemeir, R. J.; Rubin, J.; Schutt, A. J.; Weiland, L. H.; Childs, D. S.; Holbrook, M. A.; Lavin, P. T.; Livstone, E.; Ramming, K.; Douglas, H. O.; Thomas, P.; Nave, H.; Bateman, J.; Kokich, J.; Brooks, J.; Chaffey, J.; Corson, J. M.; Zamcheck, N.; Novak, J. W. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer: The Gastrointestinal Tumor Study Group. Cancer 59:2006-2010; 1987.
17. Moertel, C. G.; Frytak, S.; Hahn, R. G.; O'Connell, M. J.; Reitemeir, R. J.; Rubin, J.; Schutt, A. J.; Weiland, L. H.; Childs, D. S.; Holbrook, M. A.; Lavin, P. T.; Livstone, E.; Ramming, K.; Douglas, H. O.; Thomas, P.; Nave, H.; Bateman, J.; Kokich, J.; Brooks, J.; Chaffey, J.; Corson, J. M.; Zamcheck, N.; Novak, J. W. Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil: The Gastrointestinal Tumor Study Group. Cancer 48:1705-1710; 1991.
18. Okayasu, R.; Bloecher, D.; Iliakis, G. Variation through the cell cycle in the dose-response of DNA neutral filter elution in X-irradiated synchronous CHO-cells. Int. J. Radiat. Biol. 53:729-747; 1988.
19. Phillips, T. L.; Bodell, W. J.; Uhl, V.; Ross, G. Y.; Rasmussen, J.; Mitchell, J. B. Correlation of exposure time, concentration, and incorporation of IdUrd in V-79 cells with radiation response. Int. J. Radiat. Oncol. Biol. Phys. 16:1251-1255; 1989.
20. Poplin, E. A.; Corbett, T.; Flaherty, L.; Tarasoff, P.; Redman, B. G.; Valdivieso, M.; Baker, L. Difluorodeoxycytidine (dFdC) - Gemcitabine: A phase I study. Invest. New Drugs 10:165-170; 1992.
21. Rockwell, S.; Grindey, G. B. Effect of 2,2′-difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro. Oncol. Res. 4:151-155; 1992.
22. Shewach, D. S.; Ellero, J.; Mancini, W. R.; Ensminger, W. D. Decrease in TTP pools mediated by 5-bromo-2′-deoxyuridine exposure in a human glioblastoma cell line. Biochem. Pharmacol. 43:1579-1585; 1992.
23. Shewach, D. S.; Hahn, T. M.; Chang, E.; Hertel, L. W.; Lawrence, T. S. Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res. 54:3218-3223; 1994.
24. Sinclair, W. K. The combined effect of hydroxyurea and x-rays on Chinese hamster cells in vitro. Cancer Res. 28:198-206; 1968.
25. Sinclair, W. K. Sensitivity to mitotic delay and stage in the cycle. Curr. Top. Radiat. Res. 7:323-327; 1972.
26. Tang, H. Y.; Davis, M. A.; Strickfaden, S. M.; Maybaum, J.; Lawrence, T. S. Influence of cell cycle phase on radiation-induced cytotoxicity and DNA damage in human colon cancer (HT29) and Chinese hamster ovary cells. Radiat. Res. 138:S109-S112; 1994.
27. Terasima, T.; Tolmach, L. J. Variations in several responses of HeLa cells to X-irradiation during the division cycle. Biophys. J. 3:11-33; 1963.