The role of DNA synthesis inhibition in the cytotoxicity of 2′,2′-difluoro-2′-deoxycytidine

Cancer Chemotherapy and Pharmacology

Volumn 52, Issue 4, 2003, Pages 325-332

  Ostruszka, Leo J ^a   Shewach, Donna S ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

dFdCyd; DNA synthesis; dNTP; Ribonucleotide reductase

Indexed keywords

2',2' DIFLUORO 2' DEOXYCYTIDINE; APHIDICOLIN; CYTOTOXIC AGENT; DEOXYADENOSINE TRIPHOSPHATE; DNA; DNA POLYMERASE; HYDROXYUREA; RIBONUCLEOTIDE REDUCTASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL KILLING; CELL SURVIVAL; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; GLIOBLASTOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APHIDICOLIN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYCYTIDINE; DNA, NEOPLASM; ENZYME INHIBITORS; GLIOBLASTOMA; HUMANS; HYDROXYUREA; NUCLEIC ACID SYNTHESIS INHIBITORS; PYRIMIDINE NUCLEOSIDES; RIBONUCLEOTIDE REDUCTASES;

EID: 0142141522     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-003-0661-5     Document Type: Article

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