CD103+ intraepithelial lymphocytes - A unique population in microsatellite unstable sporadic colorectal cancer

European Journal of Cancer

Volumn 39, Issue 4, 2003, Pages 469-475

  Quinn, E ^a,b   Hawkins, N ^b   Yip, Y L ^a   Suter, C ^a   Ward, R ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Colorectal cancer; Lymphocytes; Mechanism; MSI; MSS

Indexed keywords

ANTIBODY; CD103 ANTIGEN; CD8 ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER TISSUE; CLINICAL ARTICLE; COLON MUCOSA; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE COUNT; MALE; MICROSATELLITE INSTABILITY; PHENOTYPE; PRIORITY JOURNAL; STROMA CELL; T LYMPHOCYTE SUBPOPULATION;

AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, CD8; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA CHAINS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MICROSATELLITE REPEATS; PHENOTYPE;

EID: 12244294056     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(02)00633-0     Document Type: Article

References (44)

1. Liu B., Nicolaides N.C., Markowitz S.et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat. Genet. 9:1995;48-55.
2. Bocker T., Ruschoff J., Fishel R. Molecular diagnostics of cancer predisposition. hereditary non-polyposis colorectal carcinoma and mismatch repair defects Biochim. Biophys. Acta. 1423:1999;01-010.
3. Bronner C.E., Baker S.M., Morrison P.T.et al. Mutation in the DNA mismatch repair gene homologue hmlh1 is associated with hereditary non-polyposis colon cancer. Nature. 368:1994;258-261.
4. Boland C.R. Genetic pathways to colorectal cancer. Hospital Practice. 32:1997;79-96.
5. Nicolaides N.C., Papadopoulos N., Liu B.et al. Mutations of two pms homologues in hereditary nonpolyposis colon cancer. Nature. 371:1994;75-80.
6. Papadopoulos N., Nicolaides N.C., Liu B.et al. Mutations of gtbp in genetically unstable cells. Science. 268:1995;1915-1917.
7. Cunningham J.M., Christensen E.R., Tester D.J.et al. Hypermethylation of the hmlh1 promoter in colon cancer with microsatellite instability. Cancer Res. 58:1998;3455-3460.
8. Alexander J., Watanabe T., Wu T.T., Rashid A., Li S., Hamilton S.R. Histopathological identification of colon cancer with microsatellite instability. Am. J. Pathol. 158:2001;527-535.
9. Jass J.R., Do K.A., Simms L.A.et al. Morphology of sporadic colorectal cancer with DNA replication errors. Gut. 42:1998;673-679.
10. Ward R., Meagher A., Tomlinson I.et al. Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut. 48:2001;821-829.
11. Graham D.M., Appelman H.D. Crohn's-like lymphoid reaction and colorectal carcinoma. a potential histologic prognosticator Mod. Pathol. 3:1990;332-335.
12. Cerf-Bensussan N., Begue B., Gagnon J., Meo T. The human intraepithelial lymphocyte marker hml-1 is an integrin consisting of a beta 7 subunit associated with a distinctive alpha chain. Eur. J. Immunol. 22:1992;273-277.
13. Kilshaw P.J., Murant S.J. A new surface antigen on intraepithelial lymphocytes in the intestine. Eur. J. Immunol. 20:1990;2201-2207.
14. Kilshaw P.J., Murant S.J. Expression and regulation of beta 7(beta p) integrins on mouse lymphocytes. relevance to the mucosal immune system Eur. J. Immunol. 21:1991;2591-2597.
15. Kilshaw P.J., Karecla P. Structure and function of the mucosal t-cell integrin alpha e beta 7. Biochem. Soc. Trans. 25:1997;433-439.
16. Cerf-Bensussan N., Guy-Grand D., Griscelli C. Intraepithelial lymphocytes of human gut. isolation, characterisation and study of natural killer activity Gut. 26:1985;81-88.
17. Erle D.J. Intraepithelial lymphocytes. Scratching the surface. Curr. Biol. 5:1995;252-254.
18. Morimoto Y., Hizuta A., Ding E.X.et al. Functional expression of fas and fas ligand on human intestinal intraepithelial lymphocytes. Clin. Exp. Immunol. 116:1999;84-89.
19. Guy-Grand D., Malassis-Seris M., Briottet C., Vassalli P. Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial t lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules. J. Exp. Med. 173:1991;1549-1552.
20. Guy-Grand D., Vassalli P. Gut intraepithelial t lymphocytes. Curr. Opin. Immunol. 5:1993;247-252.
21. Rocha B., Vassalli P., Guy-Grand D. Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice. J. Exp. Med. 180:1994;681-686.
22. Oida T., Suzuki K., Nanno M.et al. Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial t cells. J. Immunol. 164:2000;3616-3626.
23. Dolcetti R., Viel A., Doglioni C.et al. High prevalence of activated intraepithelial cytotoxic t lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability. Am. J. Pathol. 154:1999;1805-1813.
24. Naito Y., Saito K., Shiiba K.et al. Cd8+ t cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res. 58:1998;3491-3494.
25. Guidoboni M., Gafa R., Viel A.et al. Microsatellite instability and high content of activated cytotoxic lymphocytes identify colon cancer patients with a favorable prognosis. Am J Pathol. 159:2001;297-304.
26. Hawkins N.J., Ward R.L. Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J. Natl. Cancer Inst. 93:2001;1307-1313.
27. Hermanek P., Sobin L.H. Tnm. American Joint Committee on Cancer, Manual for Staging Cancer. 1998;Lippincott-Raven, Philadelphia.
28. Jass J.R., Sobin L.H. Histological typing of Intestinal Tumours. Who International Classification of Tumours. 1989;Springer-Verlag, Berlin.
29. Cerf-Bensussan N., Jarry A., Brousse N., Lisowska-Grospierre B., Guy-Grand D., Griscelli C. A monoclonal antibody (hml-1) defining a novel membrane molecule present on human intestinal lymphocytes. Eur. J. Immunol. 17:1987;1279-1285.
30. Parker C.M., Cepek K.L., Russell G.J.et al. A family of beta 7 integrins on human mucosal lymphocytes. Proc. Natl. Acad. Sci. USA. 89:1992;1924-1928.
31. Agace W.W., Higgins J.M., Sadasivan B., Brenner M.B., Parker C.M. T-lymphocyte-epithelial-cell interactions. integrin alpha(e)(cd103)beta(7), leep-cam and chemokines Curr. Opin. Cell. Biol. 12:2000;563-568.
32. Shibahara T., Si-Tahar M., Shaw S.K., Madara J.L. Adhesion molecules expressed on homing lymphocytes in model intestinal epithelia. Gastroenterology. 118:2000;289-298.
33. Cepek K.L., Parker C.M., Madara J.L., Brenner M.B. Integrin alpha e beta 7 mediates adhesion of t lymphocytes to epithelial cells. J. Immunol. 150:1993;3459-3470.
34. Suzuki R., Nakao A., Kanamaru Y., Okumura K., Ogawa H., Ra C. Localization of intestinal intraepithelial t lymphocytes involves regulation of alpha(e)beta(7) expression by transforming growth factor-beta. Int. Immunol. 14:2002;339-345.
35. Austrup F., Rebstock S., Kilshaw P.J., Hamann A. Transforming growth factor-beta 1-induced expression of the mucosa-related integrin alpha e on lymphocytes is not associated with mucosa-specific homing. Eur. J. Immunol. 25:1995;1487-1491.
36. Hata A. Tgfbeta signaling and cancer. Exp. Cell. Res. 264:2001;111-116.
37. Gold L.I. The role for transforming growth factor-beta (tgf-beta) in human cancer. Crit. Rev. Oncog. 10:1999;303-360.
38. Blobe G.C., Schiemann W.P., Lodish H.F. Role of transforming growth factor beta in human disease. N. Engl. J. Med. 342:2000;1350-1358.
39. Karecla P.I., Bowden S.J., Green S.J., Kilshaw P.J. Recognition of e-cadherin on epithelial cells by the mucosal t cell integrin alpha m290 beta 7 (alpha e beta 7). Eur. J. Immunol. 25:1995;852-856.
40. Higgins J.M., Mandlebrot D.A., Shaw S.K.et al. Direct and regulated interaction of integrin alphaebeta7 with e-cadherin. J. Cell. Biol. 140:1998;197-210.
41. Cepek K.L., Shaw S.K., Parker C.M.et al. Adhesion between epithelial cells and t lymphocytes mediated by e-cadherin and the alpha e beta 7 integrin. Nature. 372:1994;190-193.
42. Sarnacki S., Begue B., Buc H., Le Deist F., Cerf-Bensussan N. Enhancement of cd3-induced activation of human intestinal intraepithelial lymphocytes by stimulation of the beta 7-containing integrin defined by hml-1 monoclonal antibody. Eur. J. Immunol. 22:1992;2887-2892.
43. Roberts A.I., O'Connell S.M., Biancone L., Brolin R.E., Ebert E.C. Spontaneous cytotoxicity of intestinal intraepithelial lymphocytes. clues to the mechanism Clin. Exp. Immunol. 94:1993;527-532.
44. Roberts A.I., O'Connell S.M., Ebert E.C. Intestinal intraepithelial lymphocytes bind to colon cancer cells by hml-1 and cd11a. Cancer Res. 53:1993;1608-1611.