Improved production and function of llama heavy chain antibody fragments by molecular evolution

Journal of Biotechnology

Volumn 80, Issue 3, 2000, Pages 261-270

  Van Der Linden, Richard H J ^a,b   De Geus, Bernard ^a   Frenken, Leon G J ^c   Peters, Hans ^c   Verrips, C Theo ^b,c  

^a Pathobiology Epidemiol DLO I ^*  (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

Author keywords

DNA shuffling; Heavy chain antibody; Molecular evolution; Production; Saccharomyces cerevisiae; Stability

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; MOLECULAR EVOLUTION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS; CAMELIDS, NEW WORLD; CONSENSUS SEQUENCE; EVOLUTION, MOLECULAR; HEAT; IMMUNOGLOBULIN HEAVY CHAINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS, DNA;

EID: 0034647452     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(00)00274-1     Document Type: Article

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