Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex

Neuroscience Letters

Volumn 319, Issue 2, 2002, Pages 107-110

  Zhang, Yun Hai ^a   Zhao, Xiao Yan ^a   Chen, Xue Qin ^a   Wang, Yuan ^a   Yang, Hui Hua ^a   Hu, Guo Yuan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Alzheimer's disease; Cholinesterase inhibitor; Huperzine A; N methyl D aspartate receptors; Polyamine; 3H dizocilpine (MK 801) binding

Indexed keywords

DIZOCILPINE; GLUTAMIC ACID; GLYCINE; HUPERZINE A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SPERMIDINE;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BINDING; DRUG BINDING SITE; DRUG MECHANISM; DRUG POTENCY; IC 50; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC MEMBRANE;

ALZHEIMER DISEASE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CEREBRAL CORTEX; CHOLINESTERASE INHIBITORS; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLYCINE; NEURONS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SESQUITERPENES; SPERMIDINE; SYNAPTIC MEMBRANES;

EID: 0037083260     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02565-4     Document Type: Article

References (12)

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5. Prospects for pharmacological intervention in Alzheimer Disease
6. Cholinesterase inhibitors: From the Calabar bean to Alzheimer therapy
7. Huperzine A: A novel acetylcholinesterase inhibitor
8. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate
9. 3H] MK-801 binding in rat cerebral cortex
10. Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor
11. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment
12. Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons