Functional importance of platelet-derived growth factor (PGDF) receptor extracellular immunoglobulin-like domains. Identification of PGDF binding site and neutralizing monoclonal antibodies

Journal of Biological Chemistry

Volumn 272, Issue 52, 1997, Pages 33037-33044

  Lokker, Nathalie A ^a   O'Hare, James P ^a   Barsoumian, Arpy ^a   Tomlinson, James E ^a   Ramakrishnan, Vanitha ^a   Fretto, Larry J ^a   Giese, Neill A ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BINDING AFFINITY; BINDING SITE; DELETION MUTANT; MITOGENESIS; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; CHO CELLS; CRICETINAE; DIMERIZATION; IMMUNOGLOBULINS; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; PEPTIDE MAPPING; PHOSPHORYLATION; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0031438411     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.52.33037     Document Type: Article

References (39)

1. Wilcox, J. N., Smith, K. M., Williams, L. T., Schwartz, S. M., and Gordon, D. (1988) J. Clin. Invest. 82, 1134-1143
2. Ross, R., Masuda, J., Raines, E. W., Gown, A. M., Katsuda, S., Sasahara, M., Maiden, L. T., Masuka, H., and Sato, H. (1990) Science 248, 1009-1012
3. Johnson, R. J., Raines, E. W., Floege, J., Yoshimura, A., Pritzl, P., Alpers, C., and Ross, R. (1992) J. Exp. Med. 175, 1413-1416
4. Heldin, C. H., and Westermark, B. (1990) Cell Reg. 1, 555-566
5. Gesualdo, L., Pinzani, M., Floriano, J. J., Hassan, M. O., Nagy, N. U., Schena, F. P., Emancipator, S. N., and Abboud, H. E. (1991) Lab. Invest. 65, 160-167
6. Iida, H., Seifert, R., Alpers, C. E., Gronwald, R. G., Phillips, P. E., Pritzl, P., Gordon, K., Gown, A. M., Ross, R., Bowen-Pope, D. F., and Johnson, R. J. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 6560-6564
7. Herren, B., Rooney, B., Weyer, K. A., Iberg, N., Schmid, G., and Pech, M. (1993) J. Biol. Chem. 268, 15088-15095
8. Fretto, L. J., Snape, A. J., Tomlinson, J. E., Seroogy, J. J., Wolf, D. L., LaRochelle, W. J., and Giese, N. A. (1993) J. Biol. Chem. 268, 3625-3631
9. Heldin, C.-H., Ostman, A., Eriksson, A., Siegbahn, A., Claesson-Welsh, L., and Westermark, B. (1992) Kidney Int. 41, 571-574
10. Ullrich, A., and Schlessinger, J. (1990) Cell 61, 203-212
11. Stoddard, B. L., Biemann, H. P., and Koshland, D. E. J. (1992) Cold Spring Harbor Symp. Quant. Biol. 57, 1-15
12. Heidaran, M. A., Pierce, J. H., Yu, J.-C., Lombardi, D., Artrip, J. E., Fleming, T. P., Thomason, A., and Aaronson, S. A. (1991) J. Biol. Chem. 266, 20232-20237
13. Kanakaraj, P., Raj, S., Khan, S. A., and Bishayee, S. (1991) Biochemistry 30, 1761-1767
14. Heldin, C.-H. (1992) EMBO J. 11, 4251-4259
15. Eriksson, A., Rorsman, C., Ernlund, A., Ciaessen-Welsch, L., and Heldin, C.-H. (1992) Growth Factors 6, 1-14
16. Hart, C. E., Forstrom, J. W., Kelly, J. D., Seifert, R. A., Smith, R. A., Ross, R., Murray, M. J., and Bowen-Pope, D. F. (1988) Science 240, 1529-1531
17. Claesson-Welsh, L. (1994) J. Biol. Chem. 269, 32023-32026
18. Yarden, Y., and Ullrich, A. (1988) Annu. Rev. Biochem. 57, 443-478
19. Williams, L. T. (1989) Science 243, 1564-1570
20. Heidaran, M. A., Pierce, J. H., Jensen, R. A., Matsui, T., and Aaronson, S. A. (1990) J. Biol. Chem. 265, 18741-18744
21. Heideran, M. A., Mahadevan, D., and LaRochelle, W. J. (1995) FASEB J. 9, 140-145
22. Wang, Z., Myles, G. M., Brandt, C. S., Lioubin, M. N., and Rohrschneider, L. (1993) Mol. Cell. Biol. 13, 5348-5359
23. Lev, S., Blechman, J., Nishikawa, S.-I., Givol, D., and Yarden, Y. (1993) Mol. Cell. Biol. 13, 2224-2234
24. Blechman, J. M., Lev, S., Brizzi, M. F., Leitner, O., Pegoraro, L., Givol, D., and Yarden, Y. (1993) J. Biol. Chem. 268, 4399-4406
25. Omura, T., Heldin, C.-H., and Ostman, A. (1997) J. Biol. Chem. 272, 12676-12682
26. Blechman, J. M., Lev, S., J., B., Eisenstein, M., Vaks, B., Vogel, Z., Givol, D., and Yarden, Y. (1995) Cell 80, 103-113
27. Harlow, E., and Lane, D. (1988) Antibodies: A Laboratory Manual, 1st Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
28. Escobedo, J. A., Navankasatussas, S., Cousens, L. S., Coughlin, S. R., Bell, G. I., and Williams, L. T. (1988) Science 240, 1532-1534
29. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
30. Smith, L. M., Sanders, J. Z., Kaiser, R. J., Hughes, P., Dodd, C., Connell, C. R., Heiner, C., Kent, S. B. H., and Hood, L. E. (1986) Nature 321, 674-679
31. Takebe, Y., Seiki, M., Fujisawa, J., Hoy, P., Yokota, K., Aral, K., Yoshida, M., and Arai, N. (1988) Mol. Cell. Biol. 8, 466-472
32. Matsui, T., Pierce, J. H., Fleming, T. P., Greenberger, J. S., LaRochelle, W. J., Ruggiero, M., and Aaronson, S. A. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 8314-8318
33. Scatchard, G. (1949) Ann. N. Y. Acad. Sci. 51, 660-672
34. Gronwald, R. G. K., Grant, F. J., Haldeman, B. A., Hart, C. E., O'Hare, P. J., Hagen, F. S., Ross, R., Bowen-Pope, D. F., and Murray, M. J. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 3435-3439
35. Mahadevan, D., Yu, J.-C., Saldanha, J. W., Thanki, N., McPhie, P., Uren, A., LaRochelle, W. J., and Heideran, M. A. (1995) J. Biol. Chem. 270, 27595-27600
36. Heidaran, M. A., Yu, J.-C., Jensen, R. A., Pierce, J. H., and Aaronson, S. A. (1992) J. Biol. Chem. 267, 2884-2887
37. Yu, J.-C., Mahadevan, D., LaRochelle, W. J., Pierce, J. H., and Heidaran, M. A. (1994) J. Biol. Chem. 269, 10668-10674
38. Shulman, T., Sauer, F. G., Jackman, R. M., Chang, C. N., and Landolfi, N. F. (1997) J. Biol. Chem. 272, 17400-17404
39. Ramakrishnan, V., Escobedo, M.-A., Fretto, L. J., Seroogy, J. J., Tomlinson, J. E., and Wolf, D. L. (1993) Growth Factors 8, 253-265