The number of long-lasting functional memory CD8+ T cells generated dependes on the nature of the initial nonspecific stimulation

European Journal of Immunology

Volumn 32, Issue 6, 2002, Pages 1541-1549

  Fernando, Germain J P ^a   Khammanivong, Vithagna ^a   Leggatt, Graham R ^a   Liu, Wen Jun ^a   Frazer, Ian H ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Long lived protective immunity; Memory CTL; T help; Tumor regression; Vaccine

Indexed keywords

ANTIGEN; BINDING PROTEIN; CD8 ANTIGEN; CELL PROTEIN; EPITOPE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; CELL LINE; CELL SIZE; CELLULAR IMMUNITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; FEMALE; HELPER CELL; IMMUNIZATION; IMMUNOASSAY; IMMUNOSTIMULATION; INTERFERON PRODUCTION; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; EPITOPES, T-LYMPHOCYTE; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0036080343     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200206)32:6<1541::AID-IMMU1541>3.0.CO;2-S     Document Type: Article

References (37)

1. Immunological memory and protective immunity: Understanding their relation
2. Accessing complexity: The dynamics of virus-specific T cell responses
3. + T cell differentiation: Initial antigen encounter triggers a developmental program in naive cells
4. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
5. Selecting and maintaining a diverse T cell repertoire
6. T cell death and memory
7. Generation and maintenance of memory T cells
8. + T cells
9. Linear differentiation of cytotoxic effectors into memory T lymphocytes
10. Modelling T cell memory by genetic marking of memory T cells in vivo
11. + T cells in vivo by IL-15
12. + memory T cells by opposing cytokines
13. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
14. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
15. Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo
16. + memory T cells
17. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo
18. + cells neither enhance nor suppress antitumor CTL activity in a mouse tumor model
19. + T cell memory determined by clonal burst size
20. Coordinate regulation of complex T cell populations responding to bacterial infection
21. Epitope affinity for MHC class I determines helper requirement for CTL priming
22. Influence of strong CD4 epitope on long-term virus-specific cytotoxic T cell responses induced in vivo with peptides
23. Dendritic cell secretion of IL-15 is induced by recombinant huCD40LT and augments the stimulation of antigen-specific cytolytic T cells
24. Stimulation of memory T cells by cytokines
25. CD4 T cells and their role in antitumor immune responses
26. + cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection
27. Soluble antigen and CD40 triggering are sufficient to induce primary and memory cytotoxic T cells
28. Vaccine-induced Th1-type responses are dominant over Th2-type responses in the short term whereas pre-existing Th2 responses are dominant in the longer term
29. Saponin adjuvants. 3. Isolation of a substance from Quillaja saponaria Molina with adjuvant activity in food-and-mouth disease vaccines
30. Peptide polymerisation facilitates incorporation into ISCOMs and increases antigen-specific lgG2a production
31. T-helper epitopes of the E7 transforming protein of cervical cancer associated human papillomavirus type 18 (HPV18)
32. A "public" T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B cell epitopes from cervical cancer-associated human papillomavirus genotypes
33. Peptide vaccination with an anchor-replaced CTL epitope protects against human papillomavirus type 16-induced tumors expressing the wild-type epitope
34. Expression, purification and immunological characterization of the transforming protein E7, from cervical cancer-associated human papillomavirus type 16
35. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
36. Introduction of soluble protein into the class I pathway of antigen processing and presentation
37. + T cells using an ELISPOT assay