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Volumn 14, Issue 5, 2002, Pages 666-672

Recent advances in mucosal vaccines and adjuvants

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 18; VIRUS VACCINE;

EID: 0036774999     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00384-9     Document Type: Review
Times cited : (116)

References (37)
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    • LT and a LT mutant lacking ADP-ribosyltransferase activity were shown to be strong adjuvants for intranasally administered RSV vaccines. The vaccination induced both RSV-specific CTL and protected against RSV challenge. However, administration of LT adjuvant was also associated with enhanced disease including lung eosinophilia.
    • Simmons C.P., Hussell T., Sparer T., Walzl G., Openshaw P., Dougan G. Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8+ T cell responses. J Immunol. 166:2001;1106-1113. LT and a LT mutant lacking ADP-ribosyltransferase activity were shown to be strong adjuvants for intranasally administered RSV vaccines. The vaccination induced both RSV-specific CTL and protected against RSV challenge. However, administration of LT adjuvant was also associated with enhanced disease including lung eosinophilia.
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    • Wang, S.W.1    Kozlowski, P.A.2    Schmelz, G.3    Manson, K.4    Wyand, M.S.5    Glickman, R.6    Montefiori, D.7    Lifson, J.D.8    Johnson, R.P.9    Neutra, M.R.10
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    • Oral administration of hepatitis E virus-like particles induces a systemic and mucosal immune response in mice
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    • Recombinant Norwalk virus-like particles administered intranasally to mice induce systemic and mucosal (fecal and vaginal) immune responses
    • The authors show that VLPs are immunogenic when administered at a mucosal surface. Recombinant Norwalk VLPs given nasally to mice induced strong mucosal IgA responses in the absence of any external adjuvant. Oral vaccination was less promising.
    • Guerrero R.A., Ball J.M., Krater S.S., Pacheco S.E., Clements J.D., Estes M.K. Recombinant Norwalk virus-like particles administered intranasally to mice induce systemic and mucosal (fecal and vaginal) immune responses. J Virol. 75:2001;9713-9722. The authors show that VLPs are immunogenic when administered at a mucosal surface. Recombinant Norwalk VLPs given nasally to mice induced strong mucosal IgA responses in the absence of any external adjuvant. Oral vaccination was less promising.
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    • Guerrero, R.A.1    Ball, J.M.2    Krater, S.S.3    Pacheco, S.E.4    Clements, J.D.5    Estes, M.K.6
  • 26
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    • Papillomavirus pseudovirus: A novel vaccine to induce mucosal and systemic cytotoxic T-lymphocyte responses
    • This paper shows that VLPs can be used as carriers/adjuvants for mucosal DNA vaccination. Oral vaccination with papillomavirus VLPs containing a DNA plasmid that encode for the regulatory papillomavirus protein E7 induced strong mucosal CTL responses and protected against challenge with an E7-expressing papillomavirus.
    • Shi W., Liu J., Huang Y., Qiao L. Papillomavirus pseudovirus: a novel vaccine to induce mucosal and systemic cytotoxic T-lymphocyte responses. J Virol. 75:2001;10139-10148. This paper shows that VLPs can be used as carriers/adjuvants for mucosal DNA vaccination. Oral vaccination with papillomavirus VLPs containing a DNA plasmid that encode for the regulatory papillomavirus protein E7 induced strong mucosal CTL responses and protected against challenge with an E7-expressing papillomavirus.
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    • Infection of human dendritic cells by a sindbis virus replicon vector is determined by a single amino acid substitution in the E2 glycoprotein
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    • Gardner, J.P.1    Frolov, I.2    Perri, S.3    Ji, Y.4    MacKichan, M.L.5    Zur Megede, J.6    Chen, M.7    Belli, B.A.8    Driver, D.A.9    Sherrill, S.10
  • 28
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    • Human immunodeficiency virus type 1 Gag-specific vaginal immunity and protection after local immunizations with sindbis virus-based replicon particles
    • Highly immunogenic, replication-defective, enveloped Sindbis virus vectors are described that can carry either foreign DNA and/or express foreign proteins. Vaginal or rectal vaccination of mice with sindbis-based replicon particles expressing HIV gag antigen protected mice against a vaginal challenge with vaccinia virus expressing the same HIV gag.
    • Vajdy M., Gardner J., Neidleman J., Cuadra L., Greer C., Perri S., O'Hagan D., Polo J.M. Human immunodeficiency virus type 1 Gag-specific vaginal immunity and protection after local immunizations with sindbis virus-based replicon particles. J Infect Dis. 184:2001;1613-1616. Highly immunogenic, replication-defective, enveloped Sindbis virus vectors are described that can carry either foreign DNA and/or express foreign proteins. Vaginal or rectal vaccination of mice with sindbis-based replicon particles expressing HIV gag antigen protected mice against a vaginal challenge with vaccinia virus expressing the same HIV gag.
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    • Vajdy, M.1    Gardner, J.2    Neidleman, J.3    Cuadra, L.4    Greer, C.5    Perri, S.6    O'Hagan, D.7    Polo, J.M.8
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    • Induction of protective immunity against Chlamydia trachomatis genital infection by a vaccine based on major outer membrane protein-lipophilic immune response-stimulating complexes
    • Igietseme J.U., Murdin A. Induction of protective immunity against Chlamydia trachomatis genital infection by a vaccine based on major outer membrane protein-lipophilic immune response-stimulating complexes. Infect Immun. 68:2000;6798-6806.
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    • Igietseme, J.U.1    Murdin, A.2
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    • Targeted lymph node immunization can protect cats from a mucosal challenge with feline immunodeficiency virus
    • Finerty S., Stokes C.R., Gruffydd-Jones T.J., Hillman T.J., Barr F.J., Harbour D.A. Targeted lymph node immunization can protect cats from a mucosal challenge with feline immunodeficiency virus. Vaccine. 20:2001;49-58.
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    • Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific CTL
    • Belyakov I.M., Ahlers J.D., Clements J.D., Strober W., Berzofsky J.A. Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific CTL. J Immunol. 165:2000;6454-6462.
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    • Belyakov, I.M.1    Ahlers, J.D.2    Clements, J.D.3    Strober, W.4    Berzofsky, J.A.5
  • 34
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    • Oral administration of cholera toxin B subunit conjugated to myelin basic protein protects against experimental autoimmune encephalomyelitis by inducing transforming growth factor-beta-secreting cells and suppressing chemokine expression
    • Sun J.B., Xiao B.G., Lindblad M., Li B.L., Link H., Czerkinsky C., Holmgren J. Oral administration of cholera toxin B subunit conjugated to myelin basic protein protects against experimental autoimmune encephalomyelitis by inducing transforming growth factor-beta-secreting cells and suppressing chemokine expression. Int Immunol. 12:2000;1449-1457.
    • (2000) Int Immunol , vol.12 , pp. 1449-1457
    • Sun, J.B.1    Xiao, B.G.2    Lindblad, M.3    Li, B.L.4    Link, H.5    Czerkinsky, C.6    Holmgren, J.7
  • 35
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    • Nasal administration of Schistosoma mansoni egg antigen-cholera B subunit conjugate suppresses hepatic granuloma formation and reduces mortality in S. mansoni-infected mice
    • The authors show that mucosal tolerance using CTB as a carrier protein can be used to treat infection-induced inflammatory pathology. Intranasal delivery of S. mansoni egg antigen conjugated to CTB reduced both liver granuloma formation and mortality in S. mansoni-infected mice.
    • Sun J.B., Stadecker M.J., Mielcarek N., Lakew M., Li B.L., Hernandez H.J., Czerkinsky C., Holmgren J. Nasal administration of Schistosoma mansoni egg antigen-cholera B subunit conjugate suppresses hepatic granuloma formation and reduces mortality in S. mansoni-infected mice. Scand J Immunol. 54:2001;440-447. The authors show that mucosal tolerance using CTB as a carrier protein can be used to treat infection-induced inflammatory pathology. Intranasal delivery of S. mansoni egg antigen conjugated to CTB reduced both liver granuloma formation and mortality in S. mansoni-infected mice.
    • (2001) Scand J Immunol , vol.54 , pp. 440-447
    • Sun, J.B.1    Stadecker, M.J.2    Mielcarek, N.3    Lakew, M.4    Li, B.L.5    Hernandez, H.J.6    Czerkinsky, C.7    Holmgren, J.8
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    • Oral administration of recombinant cholera toxin subunit B inhibits IL-12-mediated murine experimental (trinitrobenzene sulfonic acid) colitis
    • This study shows that CTB is a powerful inhibitor of Th1-driven immunopathology. Oral administration of CTB given either before or after onset of trinitrobenzene sulfonic acid (TNBS)-induced colitits prevented and resolved colitis, respectively. CTB treatment was associated with a marked inhibition of IL-12 secretion which prevented the development of a TNBS-induced Th1/IFN-γ response.
    • Boirivant M., Fuss I.J., Ferroni L., De Pascale M., Strober W. Oral administration of recombinant cholera toxin subunit B inhibits IL-12-mediated murine experimental (trinitrobenzene sulfonic acid) colitis. J Immunol. 166:2001;3522-3532. This study shows that CTB is a powerful inhibitor of Th1-driven immunopathology. Oral administration of CTB given either before or after onset of trinitrobenzene sulfonic acid (TNBS)-induced colitits prevented and resolved colitis, respectively. CTB treatment was associated with a marked inhibition of IL-12 secretion which prevented the development of a TNBS-induced Th1/IFN-γ response.
    • (2001) J Immunol , vol.166 , pp. 3522-3532
    • Boirivant, M.1    Fuss, I.J.2    Ferroni, L.3    De Pascale, M.4    Strober, W.5
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    • Mucosal tolerance to a bacterial superantigen indicates a novel pathway to prevent toxic shock
    • Mucosal vaccination with superantigen can also prevent superantigen-induced toxic shock syndrome. Intranasal administration of staphylococcal enterotoxin A (SEA) protected mice against a later lethal systemic SEA challenge. The protection was associated with enhanced levels of systemic IL-10.
    • Collins L.V., Eriksson K., Ulrich R.G., Tarkowski A. Mucosal tolerance to a bacterial superantigen indicates a novel pathway to prevent toxic shock. Infect Immun. 70:2002;2282-2287. Mucosal vaccination with superantigen can also prevent superantigen-induced toxic shock syndrome. Intranasal administration of staphylococcal enterotoxin A (SEA) protected mice against a later lethal systemic SEA challenge. The protection was associated with enhanced levels of systemic IL-10.
    • (2002) Infect Immun , vol.70 , pp. 2282-2287
    • Collins, L.V.1    Eriksson, K.2    Ulrich, R.G.3    Tarkowski, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.