Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens

Journal of Experimental Medicine

Volumn 192, Issue 2, 2000, Pages 281-287

  Briken, Volker ^a   Jackman, Robin M ^b   Watts, Gerald F M ^b   Rogers, Rick A ^c   Porcelli, Steven A ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Antigen presentation; CD1; Intracellular trafficking; Lipids; Mycobacterium tuberculosis

Indexed keywords

CD1 ANTIGEN; LIPID; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ACIDIFICATION; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CELLULAR DISTRIBUTION; DENDRITIC CELL; ENDOSOME; HUMAN; HUMAN CELL; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; T LYMPHOCYTE;

ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; ANTIGENS, CD1; CELL LINE; DENDRITIC CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LIPID METABOLISM; PROTEIN ISOFORMS;

EID: 0034679562     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.2.281     Document Type: Article

References (20)

1. Porcelli, S.A. 1995. The CD1 family: a third lineage of antigen-presenting molecules. Adv. Immunol. 59:1-98.
2. Rosat, J.P., E.P. Grant, E.M. Beckman, C.C. Dascher, P.A. Sieling, D. Frederique, R.L. Modlin, S.A. Porcelli, S.T. Furlong, and M.B. Brenner. 1999. CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool. J. Immnnol. 162:366-371.
3. Joyce, S., A.S. Woods, J.W. Yewdell, J.R. Bennink, S.A. De, A. Boesteanu, S.P. Balk, R.J. Cotter, and R.R. Brutkiewicz. 1998. Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science. 279:1541-1544.
4. Beckman, E.M., S.A. Porcelli, C.T. Morita, S.M. Behar, S.T. Furlong, and M.B. Brenner. 1994. Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature. 372: 691-694.
5. Beckman, E.M., A. Melian, S.M. Behar, P.A. Sieling, D. Chatterjee, S.T. Furlong, R. Matsumoto, J.P. Rosat, R.L. Modlin, and S.A. Porcelli. 1996. CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family. J. Immunol. 157:2795-2803.
6. Porcelli, S.A., and R.L. Modlin. 1999. The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu. Rev. Immunol. 17:297-329.
7. Porcelli, S.A., B.W. Segelke, M. Sugita, I.A. Wilson, and M.B. Brenner. 1998. The CD1 family of lipid antigen-presenting molecules. Immunol. Today. 19:362-368.
8. Moody, D.B., T. Ulrichs, W. Muehlecker, D.C. Young, S.S. Gurcha, E.P. Grant, J.P. Rosat, M.B. Brenner, C.E. Costello, G.S. Besra, and S.A. Porcelli. 2000. CD1c-mediated T cell recognition of isoprenoid glycolipids in M. tuberculosis infection. Nature. 404:848-888.
9. Jackman, R.M., D.B. Moody, and S.A. Porcelli. 1999. Mechanisms of lipid antigen presentation by CD1. Crit. Rev. Immunol. 19:49-63.
10. Sugita, M., R.M. Jackman, E. van Donselaar, S.M. Behar, R.A. Rogers, P.J. Peters, M.B. Brenner, and S.A. Porcelli. 1996. Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs. Science. 273:349-352.
11. Jackman, R.M., S. Stenger, A. Lee, D.B. Moody, R.A. Rogers, K.R. Niazi, M. Sugita, R.L. Modlin, P.J. Peters, and S.A. Porcelli. 1998. The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens. Immunity. 8:341-351.
12. - T lymphocytes to a microbial antigen. Nature. 360:593-597.
13. Roncarolo, M.G., H. Yssel, J.L. Touraine, R. Bacchetta, L. Gebuhrer, J.E. de Vries, and H. Spits. 1988. Antigen recognition by MHC-incompatible cells of a human mismatched chimera. J. Exp. Med. 168:2139-2152.
14. Grant, E.P., M. Degano, J.P. Rosat, S. Stenger, R.L. Modlin, I.A. Wilson, S.A. Porcelli, and M.B. Brenner. 1999. Molecular recognition of lipid antigens by T cell receptors. J. Exp. Med. 189:195-205.
15. - cytolytic T lymphocytes. Nature. 341:447-450.
16. Briken, V., D. Lankar, and C. Bonnerot. 1997. New evidence for two MHC class II-restricted antigen presentation pathways by overexpression of a small G protein. J. Immunol. 159:4653-4658.
17. Bonnerot, C., V. Briken, V. Brachet, D. Lankar, S. Cassard, B. Jabri, and S. Amigorena. 1998. syk protein tyrosine kinase regulates Fc receptor gamma-chain-mediated transport to lysosomes. EMBO (Eur. Mol. Biol. Organ.) J. 17:4606-4616.
18. Brenner, M.B., J. McLean, S.Y. Yang, J.J. van der Poel, D. Pious, and J.L. Strominger. 1985. Clonal T lymphocyte recognition of the fine structure ot the HLA-A2 molecule. J. Immunol. 135:384-390.
19. Mukherjee, S., T.T. Soe, and F.R. Maxfield. 1999. Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails. J. Cell Biol. 144:1271-1284.
20. Sugita, M., E.P. Grant, E. van Donselaar, V.W. Hsu, R.A. Rogers, P.J. Peters, and M.B. Brenner. 1999. Separate pathways for antigen presentation by CD1 molecules. Immunity. 11:743-752.