Counter-regulation of cytolytic activity and cytokine production in HIV-1-specific murine CD8+ cytotoxic T lymphocytes by free antigenic peptide

International Immunology

Volumn 13, Issue 1, 2001, Pages 43-51

  Takahashi, Megumi ^a   Nakagawa, Yohko ^a   Berzofsky, Jay A ^b   Takahashi, Hidemi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cytokines; Cytolytic molecules; Cytotoxic T lymphocyte; Free antigenic peptide; HIV 1 IL 2R

Indexed keywords

ANTIGEN; CD8 ANTIGEN; CYTOKINE; EPITOPE; GAMMA INTERFERON; GLYCOPROTEIN GP 160; GRANZYME B; INTERLEUKIN 2; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; PEPTIDE; PERFORIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN PRESENTING CELL; ARTICLE; CELL GROWTH; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVITY; EXPOSURE; FEMALE; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOMODULATION; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SUPERNATANT;

EID: 0035176291     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.1.43     Document Type: Article

References (33)

1. + T cell
2. Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy
3. Induction of interleukin-2 activation unresponsiveness and down-regulation of the JAK-STAT system upon through the T cell receptor
4. + CTL clone
5. Induction of anergy in CD8 T cells by B cell presentation of antigen
6. An anergic cytotoxic T lymphocyte clone exhibits granule exocytosis-mediated cytotoxicity
7. + T cell: Receptor-dependent cytolysis in the absence of interleukin-2 production
8. + cytolytic T lymphocytes
9. Influenza peptide-induced self-lysis and down-regulation of cloned cytotoxic T cells
10. Immune recognition of HLA molecules down-modulates CD8 expression on cytotoxic T lymphocytes
11. + cytotoxic T lymphocytes by free antigenic peptide: A self-veto mechanism?
12. Effect of cognate peptide on cytolytic and proliferative activities of cloned cytotoxic T lymphocytes
13. + cytotoxic T lymphocytes is due to fratricide
14. Molecular analysis of the same HIV peptide functionally binding to both a class I and class II MHC molecule
15. Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant
16. Expression of the HTLV-III envelope gene by a recombinant vaccinia virus
17. An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp 160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes
18. Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein
19. Rapid colorimrtric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
20. Inhibition of CTL induction by rapamycin: IL-2 rescues granzyme B and perforin expression but only partially restores cytotoxic activity
21. Introduction of soluble protein into the class I pathway of antigen processing and presentation
22. + cytotoxic T lymphocytes
23. Induction of perforin and serine esterases in a murine cytotoxic T lymphocytes clone
24. + T cells
25. + cell response against human immunodeficiency virus: Implications for long-term survival
26. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
27. + memory T cell by opposing cytokines
28. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
29. + T cells limits their cytokine synthesis and proliferation
30. + lymphocytes
31. + T cells
32. + cells: Evidence for HLA class 1-restricted triggering of cytolytic and noncytolytic mechanisms
33. Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-α), and TNF-β when they encounter their target antigens