Rapid induction of apoptosis in CD8+ HIV-1 envelope-specific murine CTLs by short exposure to antigenic peptide

Journal of Immunology

Volumn 169, Issue 11, 2002, Pages 6588-6593

  Takahashi, Megumi ^a   Osono, Eiichi ^a   Nakagawa, Yohko ^a   Wang, Jian ^b   Berzofsky, Jay A ^c   Margulies, David H ^b   Takahashi, Hidemi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3 INHIBITOR; CYCLOSPORIN A; FAS LIGAND; GLYCOPROTEIN GP 160; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; CALCINEURIN; CASP3 PROTEIN, MOUSE; CASPASE; CASPASE 3; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE FRAGMENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION CONTROL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TARGET CELL; VIRUS LOAD; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; CYTOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CALCINEURIN; CASPASE 3; CASPASES; FEMALE; HIV ANTIGENS; HIV ENVELOPE PROTEIN GP160; HIV-1; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0036884099     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.11.6588     Document Type: Article

References (37)

1. Gallimore, A., A. Glithero, A. Godkin, A. C. Tissot, A. Pluckthun, T. Elliott, H. Hengartner, and R. Zinkernagel. 1998. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxicity T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J. Exp. Med. 187:1383.
2. Zajac, A. J., J. N. Blattman, K. Murali-Krishna, D. J. D. Sourdive, J. M. Suresh, J. D. Altman, and R. Ahmed. 1998. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188:2205.
3. Moskophidis, D., F. Lechner, H. Pircher, and R. M. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362:758.
4. Carmichael, A., X. Jin, P. Sissons, and L. Borysiewicz. 1993. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) responses at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J. Exp. Med. 177:249.
5. Kersten, M. J., M. R., Klein, A. M. Holwerda, F. Miedema, and van M. H. Oers. 1997. Epstein-Barr virus-specific cytotoxic T cell responses in HIV-1 infection: different kinetics in patients progressin to opportunistic infection or non-Hodgkin's lymphoma. J. Clin. Invest. 99:1525.
6. + T cell clones during primary HIV infection. Proc. Natl. Acad. Sci. USA 94:9848.
7. Alexander-Miller, M. A., G. R. Leggatt, A. Sarin, and J. A. Berzofsky. 1996. Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL. J. Exp. Med. 184:485.
8. Alexander-Miller, M. A., M. A. Derby, A. Sarin, P. A. Henkart, and J. A. Berzofsky. 1998. Supraoptimal peptide-major histocompatibility complex causes a decrease in Bcl-2 levels and allows tumor necrosis factor a receptor Il-mediated apoptosis of cytotoxic T lymphocytes. J. Exp. Med. 188:1391.
9. Zheng L., G. Fosher, R. E. Miller, J. Peschon, D. H. Lynch, and M. J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumor necrosis factor. Nature 377:348.
10. Speiser, D. E., E. Sebzda, T. Ohteki, M. F. Bachmann, K. Pfeffer, T. W. Mak, and P. S. Ohashi. 1996. Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo. Eur. J. Immunol. 26:3055.
11. + T cells. J. Immunol. 163:1817.
12. + T cell death. J. Immunol. 163:3131.
13. Takeshita, T., H. Takahashi, S. Kozlowski, J. D. Ahlers, C. D. Pendleton, R. L. Moore, Y. Nakagawa, K. Yokomuro, B. S. Fox, D. H. Margulies, et al. 1995. Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule. J. Immunol. 154:1973.
14. Takahashi, H., Y. Nakagawa, C. D. Pendleton, R. A. Houghten, K. Yokomuro, R. N. Germain, and J. A. Berzofsky. 1992. Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant. Science 255:333.
15. Chakrabarti, S., M. Robert-Guroff, F. Wong-Staal, R. C. Gallo, and B. Moss. 1986. Expression of the HTLV-III envelope gene by a recombinant vaccinia virus. Nature 320:535.
16. Takahashi, H., J. Cohen, A. Hosmalin, K. B. Cease, R. Houghten, J. L. Cornette, C. DeLisi, B. Moss, R. N. Germain, and J. A. Berzofsky. 1988. An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 85:3105.
17. Pamachandra, S. and G. P. Studzinski. 1995. Morphological and biochemical criteria of apoptosis. In Cell Growth and Apoptosis: A Practical Approach. G. P. Studzingski, ed. IRL Press, Oxford, p. 119.
18. Gajate, C., and F. Mollinedo. 2001. The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells. Blood 98:3860.
19. Takahashi, H., S. Merli, S. D. Purney, R. Houghten, B. Moss, R. N. Germain, and J. A. Berzofsky. 1989. A single amino acid interchange yield reciprocal CTL specificities for HIV-I gp160. Science 246:118.
20. Takahashi, H., R. Houghten, S. D. Putney, D. H. Margulies, B. Moss, R. N. Germain, and J. A. Berzofsky. 1989. Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxicity T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein. J. Exp. Med. 170:2023.
21. d MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 Å resolution: implication for T cell and NK cell recognition. Immunity 9:199.
22. d complexed with an immunodominant peptide from human immunodeficiency virus envelope glycoprotein 120. J. Mol. Biol. 283:179.
23. Xu, X. N., M. A. Purbhoo, N. Chen, J. Mongkolsapaya, J. H. Cox, U. C. Meier, S. Tafuro, P. R. Dunbar, A. K. Sewell, C. S. Hourigan, et al. 2001. A novel approach to antigen-specific deletion of CTL with minimal cellular activation using α3 domain mutants of MHC class I/peptide complex. Immunity 14:591.
24. Shibasaki, F., E. Kondo, T. Akagi, and F. McLeron. 1997. Suppression of signalling through transcription factor NF-AT by interactions between calcinurin and Bcl-2. Nature 386:728.
25. Perrino, B. A., L. Y. Ng, and T. R. Soderling. 1995. Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. J. Biol. Chem. 270:340.
26. Matsuda, S., T. Moriguchi, S. Koyasu, and E. Nishida. 1998. T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A. J. Biol. Chem. 273:12378.
27. Rodriguez-Tarduchy, G., A. G. Sahuquillo, B. Alarcon, and R. Bragado. 1996. Apoptosis but not other activation events is inhibited by a mutation in the transmembrane domain of T cell receptor β that impairs CD3ζ association. J. Biol. Chem. 271:30417.
28. 2-terminal kinase. J. Exp. Med. 191:1017.
29. Zhu, L., X. Yu, Y. Akatsuka, J. A. Cooper, and C. Anasetti. 1999. Role of mitogen-activated protein kinases in activation-induced apoptosis of T cells. Immunology 97:26.
30. + cytotoxic T lymphocytes by free antigenic peptide: a self-veto mechanisms? J. Exp. Med. 183:879.
31. + cytotoxic T lymphocytes by free antigenic peptide. Int. Immunol. 13:43.
32. + CTL. Eur. J. Immunol. 31:2951.
33. Koniaras, C., S. R. Mck, F. R. Carbone, W. R. Heath, and A. M. Lew. 1997. Peptide-induced deletion of CD8 T cells in vivo occurs via apoptosis in situ. Int. Immunol. 9:1601.
34. + T cell disposal. Eur. J. Immunol. 27:577.
35. Yokosuka, T., K. Takase, M. Suzuki, Y. Nakagawa, S. Taki, H. Takahashi, T. Fujisawa, H. Asase, and T. Saito. 2002. Predominant role of T cell receptor (TCR)-α-chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system. J. Exp. Med. 195:991.
36. Cui, H., K. Matsui, S. Omura, S., L. Schauer, R. A. Matulka, G. E. Sonenshein, and S. Ju. 1997. Proteasome regulation of activation-induced T cell death. Proc. Natl. Acad. Sci. USA 94:7515.
37. Takahashi, M., and K. Yokomuro. 1996. Mouse parenchymal liver cells in culture secrete a growth inhibitor for myeloma cells. J. Hepatol. 24:225.