-
2
-
-
0033615678
-
A direct estimate of the human αβ T cell receptor diversity
-
Arstila T.P., et al. A direct estimate of the human αβ T cell receptor diversity. Science. 286:1999;958-961.
-
(1999)
Science
, vol.286
, pp. 958-961
-
-
Arstila, T.P.1
-
3
-
-
0032171644
-
A very high level of crossreactivity is an essential feature of the T-cell receptor
-
Mason D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today. 19:1998;395-404.
-
(1998)
Immunol. Today
, vol.19
, pp. 395-404
-
-
Mason, D.1
-
4
-
-
0036360019
-
The enemy within: Keeping self-reactive T cells at bay in the periphery
-
Walker L.S., Abbas A.K. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2:2002;11-19.
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 11-19
-
-
Walker, L.S.1
Abbas, A.K.2
-
6
-
-
0014792798
-
Cell interactions in the induction of tolerance: The role of thymic lymphocytes
-
Gershon R.K., Kondo K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology. 18:1970;723-737.
-
(1970)
Immunology
, vol.18
, pp. 723-737
-
-
Gershon, R.K.1
Kondo, K.2
-
7
-
-
0036597371
-
+ suppressor T cells: More questions than answers
-
+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:2002;389-400.
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 389-400
-
-
Shevach, E.M.1
-
8
-
-
0034084162
-
Regulatory T cells in autoimmmunity
-
Shevach E.M. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18:2000;423-449.
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 423-449
-
-
Shevach, E.M.1
-
9
-
-
0037364976
-
Regulatory T cells in transplantation tolerance
-
Wood K.J., Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat. Rev. Immunol. 3:2003;199-210.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 199-210
-
-
Wood, K.J.1
Sakaguchi, S.2
-
10
-
-
0037364854
-
Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity
-
Wilson S.B., Delovitch T.L. Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity. Nat. Rev. Immunol. 3:2003;211-222.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 211-222
-
-
Wilson, S.B.1
Delovitch, T.L.2
-
11
-
-
0037361819
-
Antigen-induced regulatory T cells in autoimmunity
-
von Herrath M.G., Harrison L.C. Antigen-induced regulatory T cells in autoimmunity. Nat. Rev. Immunol. 3:2003;223-232.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 223-232
-
-
Von Herrath, M.G.1
Harrison, L.C.2
-
12
-
-
0037363585
-
Immunoregulation in the tissues by γδ T cells
-
Hayday A., Tigelaar R. Immunoregulation in the tissues by γδ T cells. Nat. Rev. Immunol. 3:2003;233-242.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 233-242
-
-
Hayday, A.1
Tigelaar, R.2
-
13
-
-
0037364804
-
Natural versus adaptive regulatory T cells
-
Bluestone J.A., Abbas A.K. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3:2003;253-257.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 253-257
-
-
Bluestone, J.A.1
Abbas, A.K.2
-
14
-
-
0142250482
-
Regulatory T cells under scrutiny
-
Bach J.F. Regulatory T cells under scrutiny. Nat. Rev. Immunol. 3:2003;189-198.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 189-198
-
-
Bach, J.F.1
-
16
-
-
0036888372
-
Cytokines: Promoters and dampeners of autoimmunity
-
Hill N., Sarvetnick N. Cytokines: promoters and dampeners of autoimmunity. Curr. Opin. Immunol. 14:2002;791-797.
-
(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 791-797
-
-
Hill, N.1
Sarvetnick, N.2
-
17
-
-
0023841728
-
Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-γ
-
Sarvetnick N., et al. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-γ Cell. 52:1988;773-782.
-
(1988)
Cell
, vol.52
, pp. 773-782
-
-
Sarvetnick, N.1
-
18
-
-
0029948898
-
Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice
-
Hultgren B., et al. Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice. Diabetes. 45:1996;812-817.
-
(1996)
Diabetes
, vol.45
, pp. 812-817
-
-
Hultgren, B.1
-
19
-
-
0031051747
-
Interferon-γ is essential for destruction of β cells and development of insulin-dependent diabetes mellitus
-
von Herrath M.G., Oldstone M.B. Interferon-γ is essential for destruction of β cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185:1997;531-539.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 531-539
-
-
Von Herrath, M.G.1
Oldstone, M.B.2
-
20
-
-
0036849492
-
γ interferon paradoxically inhibits the development of diabetes in the NOD mouse
-
Sobel D.O., et al. γ interferon paradoxically inhibits the development of diabetes in the NOD mouse. J. Autoimmun. 19:2002;129-137.
-
(2002)
J. Autoimmun.
, vol.19
, pp. 129-137
-
-
Sobel, D.O.1
-
21
-
-
0035660750
-
Constitutive β cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes
-
Holz A., et al. Constitutive β cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes. J. Clin. Invest. 108:2001;1749-1758.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1749-1758
-
-
Holz, A.1
-
22
-
-
0028926524
-
Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice
-
Trembleau S., et al. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181:1995;817-821.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 817-821
-
-
Trembleau, S.1
-
23
-
-
0037514387
-
IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-γ-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-γ
-
Trembleau S., et al. IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-γ-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-γ J. Immunol. 170:2003;5491-5501.
-
(2003)
J. Immunol.
, vol.170
, pp. 5491-5501
-
-
Trembleau, S.1
-
24
-
-
0033197919
-
Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice
-
Trembleau S., et al. Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice. J. Immunol. 163:1999;2960-2968.
-
(1999)
J. Immunol.
, vol.163
, pp. 2960-2968
-
-
Trembleau, S.1
-
25
-
-
0030858075
-
Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes
-
Trembleau S., et al. Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes. Eur. J. Immunol. 27:1997;2330-2339.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 2330-2339
-
-
Trembleau, S.1
-
26
-
-
0036560003
-
Polymorphisms in the IL-12β gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains
-
Ymer S.I., et al. Polymorphisms in the IL-12β gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains. Genes Immun. 3:2002;151-157.
-
(2002)
Genes Immun.
, vol.3
, pp. 151-157
-
-
Ymer, S.I.1
-
27
-
-
0034080318
-
The biology of chemokines and their receptors
-
Rossi D., Zlotnik A. The biology of chemokines and their receptors. Annu. Rev. Immunol. 18:2000;217-242.
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 217-242
-
-
Rossi, D.1
Zlotnik, A.2
-
28
-
-
0026799402
-
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
-
Shull M.M., et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature. 359:1992;693-699.
-
(1992)
Nature
, vol.359
, pp. 693-699
-
-
Shull, M.M.1
-
29
-
-
0034131557
-
Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
-
Gorelik L., Flavell R.A. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity. 12:2000;171-181.
-
(2000)
Immunity
, vol.12
, pp. 171-181
-
-
Gorelik, L.1
Flavell, R.A.2
-
30
-
-
0029926810
-
Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice
-
Lee M.S., et al. Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice. Transplantation. 61:1996;1112-1115.
-
(1996)
Transplantation
, vol.61
, pp. 1112-1115
-
-
Lee, M.S.1
-
31
-
-
0032056347
-
TGF-β1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype
-
King C., et al. TGF-β1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype. Immunity. 8:1998;601-613.
-
(1998)
Immunity
, vol.8
, pp. 601-613
-
-
King, C.1
-
32
-
-
0032531423
-
TGF-β1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice
-
Piccirillo C.A., et al. TGF-β1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J. Immunol. 161:1998;3950-3956.
-
(1998)
J. Immunol.
, vol.161
, pp. 3950-3956
-
-
Piccirillo, C.A.1
-
33
-
-
0035801335
-
Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor β
-
Nakamura K., et al. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor β J. Exp. Med. 194:2001;629-644.
-
(2001)
J. Exp. Med.
, vol.194
, pp. 629-644
-
-
Nakamura, K.1
-
34
-
-
0037131969
-
+ T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 T regulatory cells
-
+ T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 196:2002;1335-1346.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1335-1346
-
-
Levings, M.K.1
-
35
-
-
0037099613
-
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness
-
Piccirillo C.A., et al. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196:2002;237-246.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 237-246
-
-
Piccirillo, C.A.1
-
36
-
-
0034770605
-
Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells
-
Gorelik L., Flavell R.A. Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells. Nat. Med. 7:2001;1118-1122.
-
(2001)
Nat. Med.
, vol.7
, pp. 1118-1122
-
-
Gorelik, L.1
Flavell, R.A.2
-
37
-
-
0031854249
-
Interleukin-4 deficiency does not exacerbate disease in NOD mice
-
Wang B., et al. Interleukin-4 deficiency does not exacerbate disease in NOD mice. Diabetes. 47:1998;1207-1211.
-
(1998)
Diabetes
, vol.47
, pp. 1207-1211
-
-
Wang, B.1
-
38
-
-
0033213471
-
+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway
-
+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. Immunity. 11:1999;463-472.
-
(1999)
Immunity
, vol.11
, pp. 463-472
-
-
Homann, D.1
-
39
-
-
0029838995
-
Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice
-
Mueller R., et al. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 184:1996;1093-1099.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1093-1099
-
-
Mueller, R.1
-
40
-
-
0027131888
-
Interleukin-4-deficient mice
-
Muller W., et al. Interleukin-4-deficient mice. Res. Immunol. 144:1993;637-638.
-
(1993)
Res. Immunol.
, vol.144
, pp. 637-638
-
-
Muller, W.1
-
41
-
-
0027521572
-
Interleukin-10-deficient mice develop chronic enterocolitis
-
Kuhn R., et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:1993;263-274.
-
(1993)
Cell
, vol.75
, pp. 263-274
-
-
Kuhn, R.1
-
42
-
-
0035181582
-
Type 1 T regulatory cells
-
Roncarolo M.G., et al. Type 1 T regulatory cells. Immunol. Rev. 182:2001;68-79.
-
(2001)
Immunol. Rev.
, vol.182
, pp. 68-79
-
-
Roncarolo, M.G.1
-
43
-
-
0028346888
-
Production of interleukin 10 by islet cells accelerates immune-mediated destruction of β cells in nonobese diabetic mice
-
Wogensen L., et al. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of β cells in nonobese diabetic mice. J. Exp. Med. 179:1994;1379-1384.
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1379-1384
-
-
Wogensen, L.1
-
44
-
-
0035004982
-
Suppression of T(h)1 cell activation and prevention of autoimmune diabetes in NOD mice by local expression of viral IL-10
-
Kawamoto S., et al. Suppression of T(h)1 cell activation and prevention of autoimmune diabetes in NOD mice by local expression of viral IL-10. Int. Immunol. 13:2001;685-694.
-
(2001)
Int. Immunol.
, vol.13
, pp. 685-694
-
-
Kawamoto, S.1
-
45
-
-
0035877181
-
A dual role for TNF-α in type 1 diabetes: Islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis
-
Christen U., et al. A dual role for TNF-α in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis. J. Immunol. 166:2001;7023-7032.
-
(2001)
J. Immunol.
, vol.166
, pp. 7023-7032
-
-
Christen, U.1
-
46
-
-
0035554674
-
T cell regulation: A special job or everyone's responsibility?
-
Stockinger B., et al. T cell regulation: a special job or everyone's responsibility? Nat. Immunol. 2:2001;757-758.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 757-758
-
-
Stockinger, B.1
-
47
-
-
0037450727
-
T cell regulation as a side effect of homeostasis and competition
-
Barthlott T., et al. T cell regulation as a side effect of homeostasis and competition. J. Exp. Med. 197:2003;451-460.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 451-460
-
-
Barthlott, T.1
-
48
-
-
0036721772
-
+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7
-
+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J. Immunol. 169:2002;2461-2465.
-
(2002)
J. Immunol.
, vol.169
, pp. 2461-2465
-
-
Szanya, V.1
-
49
-
-
0022394410
-
Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells
-
Hall B.M., et al. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells. J. Exp. Med. 162:1985;1683-1694.
-
(1985)
J. Exp. Med.
, vol.162
, pp. 1683-1694
-
-
Hall, B.M.1
-
50
-
-
0033523607
-
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
-
Asseman C., et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:1999;995-1004.
-
(1999)
J. Exp. Med.
, vol.190
, pp. 995-1004
-
-
Asseman, C.1
-
51
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
Sakaguchi S., et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1995;1151-1164.
-
(1995)
J. Immunol.
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
-
52
-
-
0037097503
-
+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease
-
+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J. Immunol. 168:2002;5979-5983.
-
(2002)
J. Immunol.
, vol.168
, pp. 5979-5983
-
-
McHugh, R.S.1
Shevach, E.M.2
-
53
-
-
2242423605
-
+ regulatory T cells control Leishmania major persistence and immunity
-
+ regulatory T cells control Leishmania major persistence and immunity. Nature. 420:2002;502-507.
-
(2002)
Nature
, vol.420
, pp. 502-507
-
-
Belkaid, Y.1
-
54
-
-
0036738496
-
Testing the NKT cell hypothesis of human IDDM pathogenesis
-
Lee P.T., et al. Testing the NKT cell hypothesis of human IDDM pathogenesis. J. Clin. Invest. 110:2002;793-800.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 793-800
-
-
Lee, P.T.1
|