Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice

Transplantation

Volumn 61, Issue 7, 1996, Pages 1112-1113

  Lee, Myung Shik ^a   Sawyer, Stephen ^a   Arnush, Marc ^a   Krahl, Troy ^a   Von Herrath, Matthias ^a   Oldstone, Michael B A ^a   Sarvetnick, Nora ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1; VIRUS ANTIGEN;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DIABETES MELLITUS; GRAFT REJECTION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MOUSE; NEWBORN; NONHUMAN; PANCREAS TRANSPLANTATION; PRIORITY JOURNAL; TRANSGENIC MOUSE; VIRUS INFECTION;

ANIMALS; ANTIGEN PRESENTATION; DIABETES MELLITUS, TYPE 1; GRAFT REJECTION; LYMPHOCYTIC CHORIOMENINGITIS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED CBA; MICE, TRANSGENIC; PANCREAS TRANSPLANTATION; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HOMOLOGOUS;

EID: 0029926810     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Massague J. The transforming growth factor-β family. Annu Rev Cell Biol 1990; 6: 597.
2. Kelly J. Transforming growth factor-β. In: Kelly J, ed. Cytokines of the lung. New York: Dekker, 1993: 101.
3. Gray D, Hirokawa M, Horwitz DA. The role of transforming growth factor β in the generation of suppression: an interaction between CD8+ T and NK cells. J Exp Med 1994; 180: 1937.
4. Kuruvilla AP, Shah R, Hochwald GM, Liggitt HD, Palladino MA, Thorbecke GJ. Protective effect of transforming growth factor β1 on experimental autoimmune diseases in mice. Proc Natl Acad Sci USA 1991; 88: 2918.
5. Johns LD, Flanders KC, Ranges CE, Sriram S. Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-β1. J Immunol 1991; 147: 1792.
6. Lee M-S, Gu D, Feng L, et al. Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of TGF-β1. Am J Pathol 1995; 147: 42.
7. Brunner AM, Marquardt H, Malacko AR, Lioubin MN, Purchio AF. Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor β1 precursor. J Biol Chem 1989; 23: 13660.
8. Samuel SK, Hurta RAR, Kondaiah P, et al. Autocrine induction of tumor protease production and invasion by a metallothionein-regulated TGF-β1 (Ser223,225). EMBO J 1992; 11: 1599.
9. Oldstone MBA, Nerenberg M, Southern P, Price J, Lewicki H. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 1991; 65: 319.
10. Lee M-S, Wogensen L, Shizuru J, Oldstone MBA, Sarvetnick N. Pancreatic islet production of murine interleukin 10 does not inhibit immune-mediated tissue destruction. J Clin Invest 1994; 93: 1332.