Persistent membrane translocation of protein kinase C α during 12-O- tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells

Cell Growth and Differentiation

Volumn 7, Issue 4, 1996, Pages 419-428

  Powell, C Thomas ^a   Brittis, Nicole J ^a   Stec, Diane ^a   Hug, Hubert ^b   Heston, Warren D W ^a   Fair, William R ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

APOPTOSIS; ARTICLE; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

APOPTOSIS; CYTOPLASM; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; HUMANS; IMMUNOBLOTTING; ISOENZYMES; MALE; MEMBRANES; PROSTATE; PROSTATIC NEOPLASMS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; RNA, ANTISENSE; RNA, NEOPLASM; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0029834880     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Nishizuka, Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (Lond.), 334: 661-665, 1988.
2. Clemens, M. J., Trayner, I., and Menaya, J The role of protein kinase C isozymes in the regulation of cell proliferation and differentiation. J. Cell Sci., 103: 881-887, 1992.
3. Day, M. L., Zhao, X., Wu, S., Swanson, P. E., and Humphrey, P. A. Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells. Cell Growth & Differ., 5:735-741, 1994.
4. Young, C. Y. F., Murtha, P. E., and Zhang, J. Tumor-promoting phorbol ester-induced cell death and gene expression in a human prostate adenocarcinoma cell line. Oncology Res., 6: 203-210, 1994.
5. Krongrad, A , and Bai, G. c-fos promoter insensitivity to phorbol ester and possible role of protein kinase C in androgen-independent cancer cells. Cancer Res., 54: 6073-6077, 1995.
6. Isaacs, J. T., Lundmo, P. I., Berges, R., Martikainen, P., Kyprianou, N., and English, H. F. Androgen regulation of programmed death of normal and malignant prostatic cells. J. Androl., 13: 457-464, 1992.
7. Horoszewics, J. S., Leong, S. S., Kawinski, E., Karr, J. P., Rosenthal, H., Chu, T. M., Mirand, E. A., and Murphy, G. P. LNCaP model of human prostatic cancer Cancer Res , 43: 1809-1818, 1983.
8. Peehl, D. The male reproductive system: prostatic cell lines. In: R. J. Hay, J-G. Park, and A. Gazdar (eds.), Atlas of Human Tumor Cell Lines, pp. 387-411. San Diego: Academic Press, Inc., 1994.
9. Kyprianou, N., Martikainen, P., and Isaacs, J. T. Programmed cell death of normal and malignant prostatic cells. In: K-D. Voigt and C. Knabbe (eds.), Endocrine Dependent Tumors, pp. 69-81. New York: Raven Press, Ltd., 1991.
10. Andrews, P. E., Young, C. Y., Montgomery, B. T , and Tindall, D. J. Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line. Cancer Res., 52: 1525-1529, 1992.
11. Stabel, S., and Parker, P. J. Protein kinase C. Pharmacol. Ther., 51: 71-95, 1991.
12. Young, S., Parker, P. J., Ullrich, A., and Stabel, S. Down-regulation of protein kinase C is due to an increased rate of degradation. Biochem. J , 244: 775-779, 1987.
13. Yamada, K., Jelsema, C. L., and Beaven, M. A. Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase Cγ1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic rbl-2h3 cells. J. Immunol., 149: 1031-1037, 1992.
14. Guma, A, Munoz, P., Camps, M., Testar, X., Palacin, M., and Zorzano, A. Inhibitors such as staurosporine, H-7 or polymyxin B cannot be used in skeletal muscle to prove the role of protein kinase C on insulin action Biosci Rep , 12: 413-420, 1992.
15. Ahmed, S., Kozma, R., Monfries, C., Hall, C , Lim, H. H., Smith, P., and Lim, L. Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor. Biochem. J., 272: 767-773, 1990.
16. Leung, T., How, B-E , Manser, E , and Lim, L. Germ cell β-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis. J. Biol. Chem . 268: 3813-3816, 1993.
17. rac derived by alternative splicing of the human n-chimaerin gene, is selectively expressed in brain regions and testes. Mol Cell. Biol , 13: 4986-4998, 1993
18. Leung, T., How, B-E., Manser, E., and Lim, L. Cerebellar β2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain. J. Biol. Chem., 269: 12888-12892, 1994.
19. Kazanietz, M. G., Bustelo, X. R., Barbacid, M., Kolch, W., Mischak, H., Wong, G , Pettit, G. R., Bruns, J. D., and Blumberg, P. M Zinc finger domains and the phorbol ester pharmacore. J Biol. Chem., 269: 11590-11594, 1994.
20. Ghosh, S., Xie, W. Q., Quest, A. F. G., Mabrouk, G. M., Strum, J. C., and Bell, R M. The cysteine-rich region of Raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-Ras. J. Biol. Chem., 269: 10000-10007, 1994.
21. Ono, Y., Fujii, T , Ogita, K., Kikkaawa, U., Igarashi, K., and Nishizuka, Y. Protein kinase C ζ subspecies from rat brain: its structure, expression and properties. Proc. Natl. Acad. Sci. USA, 86: 3099-3103, 1989.
22. Ways, D. K., Cook, P. P., Webster, C., and Parker, P. J. Effect of phorbol esters on protein kinase C-ζ. J Biol. Chem., 267: 4799-4805, 1992.
23. Akimoto, K., Mizuno, K., Osada, S , Hirai, S., Tanuma, S., Suzuki, K., and Ohno, S. A new member of the third class in the protein kinase C family, PKCλ, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. J. Biol. Chem., 269: 12677-12683, 1994.
24. 2+-activated and phospholipid-dependent protein kinase. Proc. Natl Acad Sci USA, 83: 8535-8539, 1986.
25. Nishizuka, Y. Protein kinase C and lipid signalling for sustained cellular responses. FASEB J., 9: 484-496, 1995.
26. Jin, L-W., Inaba, K., and Saitoh, T. The involvement of protein kinase C in activation-induced cell death in T-cell hybridoma. Cell. Immunol., 144: 217-227, 1992.
27. Berridge, M. J. Inositol triphosphate and diacylglycerol as second messengers. Biochem. J., 220: 345-360, 1984.
28. Johannes, F-J., Prestle, J., Eis, S., Oberhagemann, P., and Pfizenmaier, K. PKCμ. is a novel, atypical member of the protein kinase C family. J. Biol. Chem , 269: 6140-6148, 1994.
29. Saito, T., Ikeda, M., Endo, T., Tsurugi, K., and Onaya, T. Increased expression of acidic ribosomal protein (PO) mRNA after phorbol ester treatment of cultured rat thyroid (FRTL-5) cells. Biochem. Biophys Res. Commun., 203: 780-788, 1994.
30. Herschman, H. R. Primary response genes induced by growth factors and tumor promoters. Annu. Rev. Biochem., 60: 281-319, 1991.
31. Isaacs, W. B., Carter, B. S., and Ewing, C M. Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles. Cancer Res., 51: 4716-4720, 1991.
32. Kozlowski, J. M., Fidler, I. J., and Hart, I. R. Metastatic behavior of human tumor cell lines grown in the nude mouse. Cancer Res., 44: 3522-3529, 1984.
33. Kaighn, M. E., Narayan, K. S., Ohnuki, Y., Lechner, J. F., and Jones, L. W. Establishment and characterization of a human prostatic carcinoma cell line (PC-3), Invest. Urol., 17: 16-23, 1979.
34. Mickey, D D., Stone, K. R., Wunderli, H., Mickey, G. H., Vollmer, R. T., and Paulson, D. F. Heterotransplanlation of a human prostatic adenocarcinoma cell line in nude mice. Cancer Res., 37: 4049-4058, 1977.
35. Roehm, N. W., Rodgers, G. H., Hatfield, S M , and Glasebrook, A. L. An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT. J. Immunol. Methods, 142: 257-265, 1991.
36. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
37. Finkenzeller, G., Marme, D., and Hug, H. Sequence of human protein kinase C a. Nucleic Acids Res., 18: 2183, 1990.
38. Laborda, J. 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res., 19: 3998, 1991.
39. Kawasaki, E. S. Amplification of RNA. In: M. A. Innis. D. H. Gelfand, J J. Sninsky, and T. J. White (eds.), PCR Protocols: A Guide to Methods and Applications, pp. 21-27. San Diego: Academic Press, Inc , 1990.
40. Sanger, F., Nicklen, S., and Coullson, A. R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA, 74: 5463-5467, 1977.
41. Melton, D. A., Krieg, P. A., Rebagliati, M. R., Maniatis, T., Zinn, K., and Green, M. R. Efficient in vitro synthesis of biologically active RNAand RNA hybridization probes from plasmids containing bacteriophage SP6 promoter. Nucleic Acids Res., 12: 7035-7056, 1984.
42. Bradford, M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72; 248-254, 1976.
43. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227; 680-685, 1970.