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Volumn 109, Issue 6, 2002, Pages 827-836

Protein kinase Cδ amplifies ceramide formation via mitochondrial signaling in prostate cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CERAMIDE; CYTOCHROME C; ETOPOSIDE; PACLITAXEL; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE C; ROTTLERIN; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; ACETOPHENONE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZOPYRAN DERIVATIVE; CASPASE; ENZYME INHIBITOR; ISOENZYME; PRKCD PROTEIN, HUMAN; PROTEIN KINASE C DELTA;

EID: 85047683702     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0214146     Document Type: Article
Times cited : (122)

References (35)
  • 1
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • (1996) Science , vol.274 , pp. 1855-1859
    • Hannun, Y.A.1
  • 3
    • 0001646169 scopus 로고    scopus 로고
    • Common regulation ofapoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation
    • (1999) J. Biol. Chem. , vol.274 , pp. 14255-14261
    • Boesen-de Cock, J.G.1
  • 5
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • (1995) Cell , vol.82 , pp. 405-414
    • Bose, R.1
  • 6
    • 0030987327 scopus 로고    scopus 로고
    • Tumor promotion by depleting cells of protein kinase C delta
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3418-3428
    • Lu, Z.1
  • 7
    • 0034541255 scopus 로고    scopus 로고
    • Neutral endopeptidase promotes phorbol ester-induced apoptosis in prostate cancer cells by inhibiting neuropeptide-induced protein kinase C delta degradation
    • (2000) Cancer Res. , vol.60 , pp. 6590-6596
    • Sumitomo, M.1
  • 10
    • 0034654498 scopus 로고    scopus 로고
    • Increased activity of the protein kinase C-delta holoenzyme in the cytoplasmic particulate fraction precedes the activation ofcaspases in polyomavirustransformed pyF111 rat Fibroblasts exposed to calphostin C or topoisomerase-II inhibitors
    • (2000) Exp. Cell. Res. , vol.255 , pp. 171-183
    • Dal Pra, I.1    Whitfield, J.F.2    Chiarini, A.3    Armato, U.4
  • 11
    • 0034698182 scopus 로고    scopus 로고
    • Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis
    • (2000) J. Biol. Chem. , vol.275 , pp. 21793-21796
    • Majumder, P.K.1
  • 13
    • 0033525685 scopus 로고    scopus 로고
    • Ceramide induces cytochrome c release from isolated mitochondria. Importance of mitochondrial redox state
    • (1999) J. Biol. Chem. , vol.274 , pp. 6080-6084
    • Ghafourifar, P.1
  • 14
    • 0031035381 scopus 로고    scopus 로고
    • Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis
    • (1997) J. Biol. Chem. , vol.272 , pp. 2452-2458
    • Sawai, H.1
  • 16
    • 0039765390 scopus 로고    scopus 로고
    • Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta
    • (2000) J. Biol. Chem. , vol.275 , pp. 7574-7582
    • Fujii, T.1
  • 17
    • 0032523941 scopus 로고    scopus 로고
    • 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase
    • (1998) Cancer Res. , vol.58 , pp. 2260-2264
    • Garzotto, M.1
  • 18
    • 0029834880 scopus 로고    scopus 로고
    • Persistent membrane translocation of protein kinase C alpha during 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells
    • (1996) Cell Growth Differ. , vol.7 , pp. 419-428
    • Powell, C.T.1
  • 19
    • 0033653064 scopus 로고    scopus 로고
    • Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling
    • (2000) J. Clin. Invest. , vol.106 , pp. 1399-1407
    • Sumitomo, M.1
  • 20
    • 0031813150 scopus 로고    scopus 로고
    • Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the eta and delta isoforms of protein kinase C
    • (1998) Mol. Cell Biol. , vol.18 , pp. 5199-5207
    • Ohba, M.1
  • 21
    • 0032961680 scopus 로고    scopus 로고
    • Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression
    • (1999) Hum. Gene Ther. , vol.10 , pp. 37-47
    • Sumitomo, M.1
  • 23
    • 0028905280 scopus 로고
    • Characterization of a protein kinase C-delta (PKC-delta) ATP binding mutant. An inactive enzyme that competitively inhibits wild type PKC-delta enzymatic activity
    • (1995) J. Biol. Chem. , vol.270 , pp. 8311-8318
    • Li, W.1    Yu, J.C.2    Shin, D.Y.3    Pierce, J.H.4
  • 25
    • 0030916669 scopus 로고    scopus 로고
    • The proto-oncogene Bcl-2 and its role in regulating apoptosis
    • (1997) Nat. Med. , vol.3 , pp. 614-620
    • Kroemer, G.1
  • 29
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1
  • 33
    • 0030006040 scopus 로고    scopus 로고
    • Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis
    • (1996) EMBO J. , vol.15 , pp. 2417-2424
    • Jaffrezou, J.P.1
  • 34
    • 0034708594 scopus 로고    scopus 로고
    • Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
    • (2000) J. Biol. Chem. , vol.275 , pp. 9078-9084
    • Perry, D.K.1
  • 35
    • 0034631827 scopus 로고    scopus 로고
    • Sphingomyelin hydrolysis to ceramide during the execution phase ofapoptosis results from phospholipid scrambling and alters cell-surface morphology
    • (2000) J. Cell Biol. , vol.150 , pp. 155-164
    • Tepper, A.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.