Total synthesis of phorboxazole A

Journal of the American Chemical Society

Volumn 120, Issue 22, 1998, Pages 5597-5598

  Forsyth, Craig J ^a   Ahmed, Feryan ^a   Cink, Russell D ^a   Lee, Chi Sing ^a  

^a University of Minnesota   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHORBOXAZOLE A; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER; CELL CYCLE; DRUG ISOLATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LETTER; SPONGE (PORIFERA);

EID: 0032503570     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja980621g     Document Type: Article

References (18)

1. Searle, P. A.; Molinski, T. F. J. Am. Chem. Soc. 1995, 117, 8126.
2. Searle, P. A.; Molinski, T. F.; Brzezinski, L. J.; Leahy, J. W. J. Am. Chem. Soc. 1996, 118, 9422.
3. Molinski, T. F. Tetrahedron Lett. 1996, 37, 7879.
4. Samples of 1 derived from natural sources are presently scarce. Prof. T. F. Molinski, personal communication, 1997.
5. Ahmed, F.; Forsyth, C. J. Tetrahedron Lett. 1998, 39, 183.
6. Cink, R. D.; Forsyth, C. J. J. Org. Chem. 1997, 62, 5672.
7. Lee, C. S.; Forsyth, C. J. Tetrahedron Lett. 1996, 37, 6449.
8. Tao, Y.; Pattenden, G. Tetrahedron Lett. 1998, 39, 319.
9. Sheehan, J. C.; Cruickshank, P. A.; Boshart, G. L. J. Org. Chem. 1961, 26, 2525.
10. Wipf, P.; Lim, S. J. Am. Chem. Soc. 1995, 117, 558.
11. Sen, P. K.; Veal, C. J.; Young, D. W. J. Chem. Soc., Perkin Trans, 1 1981, 3503.
12. Dess, D. B.; Martin, J. C. J. Am. Chem. Soc. 1991, 113, 7277.
13. Horita, K.; Yoshioka, T.; Tanaka, T.; Oikawa, Y.; Yonemitsu, O. Tetrahedron 1986, 42, 3021.
14. Blanchette, M. A.; Choy, W.; Davis, J. T.; Essenfeld, A. P.; Masamune, S.; Roush, W. R.; Sakai, T. Tetrahedron Lett. 1984, 25, 2183.
15. Still, W. C.; Germari, C. Tetrahedron Lett. 1983, 24, 4495.
16. 1 See the Supporting Information.
17. Newton, R. F.; Reynolds, D. P. Tetrahedron Lett. 1979, 41, 3981.
18. 1 see the Supporting Information for full experimental details and characterization data.