Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: Implications for the resolution of inflammation

Journal of Endocrinology

Volumn 178, Issue 1, 2003, Pages 29-36

  Heasman, S J ^b   Giles, K M ^a   Ward, C ^b   Rossi, A G ^b   Haslett, C ^b   Dransfield, I ^b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLIC AMP; GLUCOCORTICOID; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P130;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; CELL CULTURE; CELL DEATH; CELL DIFFERENTIATION; DRUG EFFICACY; EOSINOPHIL; GRANULOCYTE; IMMUNOREGULATION; IN VITRO STUDY; INFLAMMATORY DISEASE; INTERNALIZATION; MACROPHAGE; MONOCYTE; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TARGET CELL DESTRUCTION;

APOPTOSIS; CYTOKINES; EOSINOPHILS; EXTRACELLULAR MATRIX; GLUCOCORTICOIDS; GRANULOCYTES; HUMANS; HYPERSENSITIVITY; MACROPHAGES; NEUTROPHILS; NF-KAPPA B; PHAGOCYTOSIS;

EID: 0043172315     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1780029     Document Type: Review

References (56)

1. Baumann I, Kolowos W, Voll RE, Manger B, Gaipl U, Neuhuber WL, Kirchner T, Kalden JR and Herrmann M 2002 Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis and rheumatism 46 191-201.
2. Bellingan GJ, Caldwell H, Howie SE, Dransfield I and Haslett C 1996 In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes. Journal of Immunology 157 2577-2585.
3. Beutler B 2001 Autoimmunity and apoptosis: the Crohn's connection. Immunity 15 5-14.
4. Botto M 2001 Links between complement deficiency and apoptosis. Arthritis Research 3 207-210.
5. Botto M, Dell'Agnola C, Bygrave AE, Thompson EM, Cook HT, Petry F, Loos M, Pandolfi PP & Walport MJ 1998 Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nature Genetics 19 56-59.
6. Bourguignon LY, Zhu H, Shao L & Chen YW 2000 CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration. Journal of Biological Chemistry 275 1829-1838.
7. Chung S, Gumienny TL, Hengartner MO & Driscoll M 2000 A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans. Nature Cell Biology 2 931-937.
8. Cox G 1995 Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes. Journal of Immunology 154 4719-4725.
9. Coxon A, Tang T & Mayadas TN 1999 Cytokine-activated endothelial cells delay neutrophil apoptosis in vitro and in vivo. A role for granulocyte/macrophage colony-stimulating factor. Journal of Experimental Medicine 190 923-934.
10. Dransfield I, Buckle AM, Savill JS, McDowall A, Haslett C & Hogg N 1994 Neutrophil apoptosis is associated with a reduction in CD16 Fc gamma RIII expression. Journal of Immunology 153 1254-1263.
11. Dransfield I, Stocks SC & Haslett C 1995 Regulation of cell adhesion molecule expression and function associated with neutrophil apoptosis. Blood 85 3264-3273.
12. Ellis RE, Jacobson DM & Horvitz HR 1991 Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics 129 79-94.
13. Fujihara S, Ward C, Dransfield I, Hay R, Uings I, Hayes B, Farrow S, Haslett C & Rossi A 2002 Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis. European Journal of immunology 32 457-466.
14. Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac. Journal of Immunology 167 976-986.
15. Godson C, Mitchell S, Harvey K, Petasis NA, Hogg N & Brady HR 2000 Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. Journal of Immunology 164 1663-1667.
16. Greidinger EL 2001 Apoptosis in lupus pathogenesis. Frontiers in Bioscience 6 D1392-D1402.
17. Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO & Ravichandran KS 2001 CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell 107 27-41.
18. Hannah S, Mecklenburgh K, Rahman I, Bellingan GJ, Greening A, Haslett C & Chilvers ER 1995 Hypoxia prolongs neutrophil survival in vitro. FEBS Letters 372 233-237.
19. Hart SP, Dougherty GJ, Haslett C & Dransfield I 1997 CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages. Journal of Immunology 159 919-925.
20. Haslett C, Lee A, Savill JS, Meagher L & Whyte MK 1991 Apoptosis programmed cell death and functional changes in aging neutrophils. Modulation by inflammatory mediators. Chest 99 6S.
21. Haslett C, Savill JS, Whyte MK, Stern M, Dransfield I & Meagher LC 1994 Granulocyte apoptosis and the control of inflammation. Philosophical Transactions of the Royal Society of London 345 327-333.
22. Hofman P, Piche M, Far DF, Le Negrate G, Selva E, Landraud L, Alliana-Schmid A, Boquet P & Rossi B 2000 Increased Escherichia coli phagocytosis in neutrophils that have transmigrated across a cultured intestinal epithelium. Infection and Immunity 68 449-455.
23. Homburg CH, de Haas M, dem Borne AE, Verhoeven AJ, Reutelingsperger CP & Roos D 1995 Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro. Blood 85 532-540.
24. Lee A, Whyte MK & Haslett C 1993 Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. Journal of Leukocyte Biology 54 283-288.
25. Liu QA & Hengartner MO 1998 Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. clegans. Cell 93 961-972.
26. Liu Y, Cousin JM, Hughes J, Van Damme J, Seckl JR, Haslett C, Dransfield I, Savill J & Rossi AG 1999 Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. Journal of Immunology 162 3639-3646.
27. Lorenz HM, Herrmann M, Winkler T, Gaipl U & Kalden JR 2000 Role of apoptosis in autoimmunity. Apoptosis 5 443-449.
28. McCutcheon JC, Hart SP, Canning M, Ross K, Humphries MJ & Dransfield I 1998 Regulation of macrophage phagocytosis of apoptotic neutrophils by adhesion to fibronectin. Journal of Leukocyte Biology 64 600-607.
29. Martin MC, Dransfeld I, Haslett C & Rossi AG 2001 Cyclic AMP regulation of neutrophil apoptosis occurs via a novel protein kinase A-independent signaling pathway. Journal of Biological Chemistry 276 45041-45050.
30. May RC 2001 Phagocytosis in C. elegans: CED-1 reveals its secrets. Trends in Cell Biology 11 150.
31. Meagher LC, Savill JS, Baker A, Fuller RW & Haslett C 1992 Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2. Journal of Leukocyte Biology 52 269-273.
32. Meagher LC, Cousin JM, Seckl JR & Haslett C 1996 Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. Journal of Immunology 156 4422-4428.
33. Murray J, Barbara JA, Dunkley SA, Lopez AF, Van OX, Condliffe AM, Dransfield I, Haslett C & Chilvers ER 1997 Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. Blood 90 2772-2783.
34. O'Neill LA & Dinarello CA 2000 The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunology Today 21 206-209.
35. Pitzalis C, Pipitone N & Perretti M 2002 Regulation of leukocyte-endothelial interactions by glucocorticoids. Annals of the New York, Academy of Sciences 966 108-118.
36. Reddien PW & Horvitz HR 2000 CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nature Cell Biology 2 131-136.
37. Rossi AG, Cousin JM, Dransfield I, Lawson MF, Chilvers ER & Haslett C 1995 Agents that elevate cAMP inhibit human neutrophil apoptosis. Biochemical and Biophysical Research Communications 217 892-899.
38. Rossi AG, McCutcheon JC, Roy N, Chilvers ER, Haslett C & Dransfield I 1998 Regulation of macrophage phagocytosis of apoptotic cells by cAMP Journal of Immunology 160 3562-3568.
39. Savill JS, Wyllie AH, Henson JE, Walport MJ, Henson PM & Haslett C 1989a Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. Journal of Clinical Investigation 83 865-875.
40. Savill JS, Henson PM & Haslett C 1989b Phagocytosis of aged human neutrophils by macrophages is mediated by a novel 'charge-sensitive' recognition mechanism. Journal of Clinical Investigation 84 1518-1527.
41. Savill J, Dransfield I, Hogg N & Haslett C 1990 Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 342 170-173.
42. Savill J, Hogg N, Ren Y & Haslett C 1992 Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. Journal of Clinical Investigation 90 1513-1522.
43. Stern M, Meagher L, Savill J & Hoslett C 1992 Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5. Journal of Immunology. 148 3543-3549.
44. Stern M, Savill J & Haslett C 1996 Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis. Mediation by alpha v beta 3/CD36/thrombospondin recognition mechanism and lack of phlogistic response. American Journal of Pathology 149 911-921.
45. Stuart L & Hughes J 2002 Apoptosis and autoimmunity. Nephrology, Dialysis, Transplantation 17 697-700.
46. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Pure E, Henson PM & Noble PW 2002 Resolution of lung inflammation by CD44. Science 296 155-158.
47. Triantafilou M & Triantafilou K 2002 Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends in Immunology 23 301-304.
48. Ward C, Hannah S, Chilvers ER, Farrow S, Haslett C & Rossi AG 1997 Transforming growth factor-beta increases the inhibitory effects of GM-CSF and dexamethasone on neutrophil apoptosis. Biochemical Society Transactions 25 244S.
49. Ward C, Dransfield I, Chilvers ER, Haslett C & Rossi AG 1999a Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets. Trends in Pharmacological Sciences 20 503-509.
50. Ward C, Chilvers ER, Lawson MF, Pryde JG, Fujihara S, Farrow SN, Haslett C & Rossi AG 1999b NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro. Journal of Biological Chemistry 274 4309-4318.
51. 2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor- gamma-independent mechanism. Journal of Immunology 168 6232-6243.
52. Webster JI, Tonelli L & Sternberg EM 2002 Neuroendocrine regulation of immunity. Annual Review of Immunology 20 125-163.
53. Whyte MK, Meagher LC, MacDermot J & Haslett C 1993a Impairment of function in aging neutrophils is associated with apoptosis. Journal of Immunology 150 5124-5134.
54. Whyte MK, Hardwick SJ, Meagher LC, Savill JS & Haslett C 1993b Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro. Journal of Clinical Investigation 92 446-455.
55. Wu YC & Horvitz HR 1998a C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature 392 501-504.
56. Wu YC & Horvitz HR 1998b The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters. Cell 93 951-960.