Autoimmunity and apoptosis: The Crohn's connection

Immunity

Volumn 15, Issue 1, 2001, Pages 5-14

  Beutler, Bruce ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; FAS ANTIGEN; PROTEIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

APOPTOSIS; AUTOIMMUNITY; CELL DEATH; CHROMOSOME 16; CROHN DISEASE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE COURSE; GENE MUTATION; HUMAN; INFLAMMATORY DISEASE; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; ULCERATIVE COLITIS;

EID: 0034906019     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00176-5     Document Type: Review

References (74)

1. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice
2. Toll-like receptors in the induction of the innate immune response
3. A conserved signaling pathway: The Drosophila toll-dorsal pathway
4. The PYRIN domain: A novel motif found in apoptosis and inflammation proteins
5. Tlr4: Central component of the sole mammalian LPS sensor
6. TNF, apoptosis and autoimmunity: A common thread?
7. Spontaneous chronic colitis in TCR alpha-mutant mice; an experimental model of human ulcerative colitis
8. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
9. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
10. high/low T cell imbalance, and suppression of type I diabetes mellitus result from TNF blockade in NOD ⇒ NOD-scid adoptive T cell transfer
11. Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: Findings in open-label and randomized placebo-controlled trials
12. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
13. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
14. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1
15. Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice
16. Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16
17. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex: Transfer from CD14 to TLR4 and MD-2
18. Binding studies and localization of Escherichia coli lipopolysaccharide in cultured hepatocytes by an immunocolloidal-gold technique
19. Three novel mammalian toll-like receptors: Gene structure, expression, and evolution
20. RAIDD is a new `death' adaptor molecule
21. Human card12 is a novel ced4/apaf-1 family member that induces apoptosis
22. High susceptibility of strain A mice to endotoxin and endotoxin-red blood cell mixtures
23. Cutting edge: Repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2
24. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
25. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
26. Iceberg: A novel inhibitor of interleukin-1beta generation
27. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis
28. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
29. Human nod1 confers responsiveness to bacterial lipopolysaccharides
30. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever
31. Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): Similarities between TNF-alpha and interleukin 1
32. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
33. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats
34. A structural basis of the interactions between leucine-rich repeats and protein ligands
35. Endocytosis of lipopolysaccharide in mouse macrophages
36. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
37. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
38. The pyrin domain: A possible member of the death domain-fold family implicated in apoptosis and inflammation
39. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells
40. RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase
41. Immunocytochemical localization of bacterial lipopolysaccharide with colloidal-gold probes in different target cells
42. Flice, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
43. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
44. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
45. PAAD - A new protein domain associated with apoptosis, cancer and autoimmune diseases
46. Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells
47. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
48. Genetic and physical mapping of the Lps locus- identification of the toll-4 receptor as a candidate gene in the critical region
49. Physical contact between LPS and Tlr4 revealed by genetic complementation
50. Identification of Ipaf, a human caspase-1 activating protein related to Apaf-1
51. Antibody-dependent killing of erythrocyte and tumor targets by macrophage-related cell lines: Enhancement by PPD and LPS
52. Functional macrophage cell lines transformed by Abelson leukemia virus
53. A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice
54. Long term safety of infliximab
55. Rip: A novel protein containing a death domain that interacts with Fas/Apo-1 (CD95) in yeast and causes cell death
56. Genetic control of leucocyte responses to endotoxin
57. RIP3, a novel apoptosis-inducing kinase
58. Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice
59. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
60. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1
61. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
62. Experimental disease in infant goats induced by a Mycobacterium isolated from a patient with Crohn's disease. A preliminary report
63. Molecules involved in cell death and peripheral tolerance
64. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
65. Host modifier genes affect mouse autoimmunity induced by the lpr gene
66. Characteristics of lipopolysaccharide interaction with human peripheral- blood monocytes
67. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
68. Stable expression of lipooligosaccharide antigens during attachment, internalization, and intracellular processing of Neisseria gonorrhoeae in infected epithelial cells
69. Three-dimensional structure of a complex between the death domains of Pelle and Tube
70. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
71. Effect of tumor necrosis factor α on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process
72. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB
73. Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I
74. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3